Jobelyn® extends the life span and improves motor function in Drosophila melanogaster exposed to lipopolysaccharide via augmentation of antioxidant status [0.03%]
Jobelyn®通过增强抗氧化状态延长脂多糖暴露的果蝇寿命并改善其运动功能
Ruth John,Amos Olalekan Abolaji,Adeola Oluwatosin Adedara et al.
Ruth John et al.
Jobelyn® (JB), a dietary supplement, derived from polyphenol-rich leaf sheath of Sorghum bicolor, has been reported to attenuate sensorimotor deficits and oxidative stress evoked by complete Freund-adjuvant in mice. This present study eval...
A focus on natural products for preventing and cure of mitochondrial dysfunction in Parkinson's disease [0.03%]
针对帕金森病线粒体功能障碍防治的天然药物研究聚焦点
Abbas Mohammadipour
Abbas Mohammadipour
Mitochondria are considered the only source of energy production within cells. This organelle is vital for neural function and survival by producing energy (adenosine triphosphate (ATP)) and regulating intracellular calcium. Mitochondrial d...
Inhibition of caspase-1 ameliorates tauopathy and rescues cognitive impairment in SAMP8 mice [0.03%]
Caspase-1抑制改善SAMP8小鼠tau病变并缓解认知障碍
Meng-Shan Tan,Yi Liu,Hao Hu et al.
Meng-Shan Tan et al.
The inflammasome assembles leading to increased cleavage and activity of caspase-1 and downstream IL-1β release, which plays a significant role in the pathogenesis of Alzheimer's disease (AD). Previous studies have shown that caspase-1-med...
Protective effect of Juglanin against doxorubicin-induced cognitive impairment in rats: Effect on oxidative, inflammatory and apoptotic machineries [0.03%]
核桃酮对阿霉素致大鼠认知功能障碍的保护作用：氧化、炎症和凋亡机制研究
Tao Wei,Lei Wang,Jian Tang et al.
Tao Wei et al.
Doxorubicin (DOX) is an effective anticancer drug, however, side effects such as cognitive impairment and cardiotoxicity have limited its clinical use. Juglanin (JUG) is a flavonoid with excellent antioxidant, anti-inflammatory, neuroprotec...
Zhihan Wang,Dabin Ren,Ping Zheng
Zhihan Wang
Epilepsy is one of the most severe neurological disorders characterized by spontaneous recurrent seizures. Although more than two-thirds of patients can be cured with anti-epileptic drugs (AEDs), the rest one-third of epilepsy patients are ...
Significant Association of rs77493513 Polymorphism in 3'-UTR of the NRG1 Gene with the Risk of Multiple Sclerosis Disease [0.03%]
NRG1基因的3'-UTR区多态性位点rs77493513与多发性硬化发病风险显著相关性研究
Maedeh Ghorbani,Parisa Mohamadynejad,Mehdi Moghanibashi
Maedeh Ghorbani
Multiple sclerosis (MS) is a chronic inflammatory and autoimmune disease characterized by demyelination of the central nervous system (CNS). Neuregulin 1 (NRG1) is a signaling protein that plays an important role in a variety of biological ...
Psychometric methods for diagnosing and monitoring minimal hepatic encephalopathy -current validation level and practical use [0.03%]
心理测验在诊断和监测亚临床肝性脑病中的应用及验证水平和实用性
Mads Kingo Guldberg Hansen,Kristoffer Kjærgaard,Lotte Lindgreen Eriksen et al.
Mads Kingo Guldberg Hansen et al.
Hepatic encephalopathy (HE) is cerebral dysfunction caused by liver failure and inflicts 30-40% of patients with liver cirrhosis during their disease course. Clinically manifest HE is often preceded by minimal HE (MHE) - a clinically undete...
Correction to: RNA as a Source of Biomarkers for Amyotrophic Lateral Sclerosis [0.03%]
Correction to: 以RNA作为肌萎缩侧索硬化生物标志物来源的研究
Lily Kiaei,Mahmoud Kiaei
Lily Kiaei
Published Erratum
Metabolic brain disease. 2022 Mar;37(3):849. DOI:10.1007/s11011-022-00924-7 2022
Alzheimer's disease therapy based on acetylcholinesterase inhibitor/blocker effects on voltage-gated potassium channels [0.03%]
基于乙酰胆碱酯酶抑制剂/阻滞剂对电压门控钾通道的作用的阿尔茨海默病疗法
Xian-Tao Li
Xian-Tao Li
Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder with progressive loss of memory and other cognitive functions. The pathogenesis of this disease is complex and multifactorial, and remains obscure until now. To enhan...
Circular RNA circSLC8A1 inhibits the proliferation and invasion of glioma cells through targeting the miR-214-5p/CDC27 axis [0.03%]
Circular RNA circSLC8A1通过靶向miR-214-5p/CDC27轴抑制胶质瘤细胞的增殖和侵袭
Jiabao Zhu,Xiaobin Liu,Zhonghua Luan et al.
Jiabao Zhu et al.
Circular RNA circSLC8A1 is one of the cancer-related circRNAs that is implicated in various cancers. However, studies focusing on the role of circSLC8A1 in glioma is rare. Here we attempted to evaluate the biological function of circSLC8A1 ...