A rare cause of hydrops fetalis in two Gaucher disease type 2 patients with a novel mutation [0.03%]
两项婴儿型戈谢病的新突变导致胎儿水肿的罕见原因
Sebile Kılavuz,Murat Basaranoglu,Serdar Epcacan et al.
Sebile Kılavuz et al.
Gaucher disease type 2 is the most progressive and the rarest form of Gaucher disease, defined as the acute neuronopathic type. We presented two GD2 patients who died before three months of age due to severe septicemia, respiratory and live...
METTL7B contributes to the malignant progression of glioblastoma by inhibiting EGR1 expression [0.03%]
METTL7B通过抑制EGR1表达促进胶质母细胞瘤恶性进展
Li Xu,Biao Peng,Haiqiang Wu et al.
Li Xu et al.
Glioblastoma (GBM), a predominant central nervous system (CNS) malignancy, is correlated with high mortality and severe morbidity. Mammalian methyltransferase-like 7B (METTL7B) as a methyltransferase has been identified to participate in ca...
Effects of inhibiting astrocytes and BET/BRD4 chromatin reader on spatial memory and synaptic proteins in rats with Alzheimer's disease [0.03%]
抑制星形胶质细胞和BET/BRD4染色质阅读蛋白对阿尔茨海默病大鼠空间记忆及突触蛋白的影响
Rastin Nikkar,Aghil Esmaeili-Bandboni,Mahshid Badrikoohi et al.
Rastin Nikkar et al.
Communication between astrocytes and neurons has a profound effect on the pathophysiology of Alzheimer's disease (AD). Astrocytes regulate homeostasis and increase synaptic plasticity in physiological situations, however, they become activa...
Recent advancements in biomarker research in schizophrenia: mapping the road from bench to bedside [0.03%]
schizophrenia生物标志物研究的新进展：从实验台到病床的道路地图
Shivangi Patel,Dilip Sharma,Ankit Uniyal et al.
Shivangi Patel et al.
Schizophrenia (SZ) is a severe progressive neurodegenerative as well as disruptive behavior disorder affecting innumerable people throughout the world. The discovery of potential biomarkers in the clinical scenario would lead to the develop...
A single injection of pregabalin induces short- and long-term beneficial effects on fear memory and anxiety-like behavior in rats with experimental type-1 diabetes mellitus [0.03%]
单一注射普瑞巴林对实验性1型糖尿病大鼠恐惧记忆和类似焦虑行为的短期和长期益处
Alvaro Henrique Bernardo de Lima Silva,Debora Rasec Radulski,Gabriela Saidel Pereira et al.
Alvaro Henrique Bernardo de Lima Silva et al.
Anxiety Disorders and Posttraumatic Stress Disorders (PTSD) associated with type-1 diabetes mellitus (T1DM) are increasingly common comorbidities and the treatment is quite challenging. In that sense, evidence indicates that the anticonvuls...
Protective effect of curcumin against rotenone-induced substantia nigra pars compacta neuronal dysfunction [0.03%]
姜黄素对鱼藤酮诱导的黑质致密部神经元损伤的保护作用研究
L V Darbinyan,K V Simonyan,L E Hambardzumyan et al.
L V Darbinyan et al.
Rotenone is involved in the degeneration of dopaminergic neurons, and curcumin may prevent or effectively slow the progression of Parkinson's disease (PD). Previous research has shown that the naturally occurring phenolic compound curcumin ...
Exploring the Potential Antidepressant Mechanisms of Pinellia by Using the Network Pharmacology and Molecular Docking [0.03%]
基于网络药理学和分子对接研究半夏的潜在抗抑郁机制
Yu-Gang Xiao,Han-Biao Wu,Ji-Sheng Chen et al.
Yu-Gang Xiao et al.
About 350 million people worldwide suffered from depression, but less than half of the patients received effective and regular treatments. Traditional Chinese Medicine (TCM) such as pinellia has been proven effective for antidepressant trea...
Paeoniflorin ameliorates cognitive impairment in Parkinson's disease via JNK/p53 signaling [0.03%]
芍药苷通过JNK/p53信号改善帕金森病认知障碍
Zhu-Qing He,Peng-Fei Huan,Li Wang et al.
Zhu-Qing He et al.
Paeoniflorin (PF) has numerous benefits, including anti-inflammatory and anti-apoptosis effects. However, it is not clear if it has neuroprotective effects against cognitive impairment (CI) in Parkinson's disease (PD). Through network pharm...
A multi-parameter evaluation of the neuroprotective and cognitive-enhancing effects of Origanum onites L. (Turkish Oregano) essential oil on scopolamine-induced amnestic rats [0.03%]
一种土耳其香料植物中草药对司可林致健忘型实验大鼠的神经保护和认知增强效果的多参数评价研究
Asli Aykac,Kerem Teralı,Dilek Özbeyli et al.
Asli Aykac et al.
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive deterioration of cognitive functions (dementia) and represents a growing public health concern since the population in the age groups at risk is increasin...
1-benzoyl-6-hydroxy-2,2,4-trimethyl-1,2-dihydroquinoline exerts a neuroprotective effect and normalises redox homeostasis in a rat model of cerebral ischemia/reperfusion [0.03%]
1-苯甲酰基-6-羟基-2，2，4-三甲基-1，2-二氢喹啉对脑缺血再灌注大鼠模型的神经保护作用及改善其氧化应激反应的影响研究
E D Kryl&#x;skii,E E Chupandina,T N Popova et al.
E D Kryl&#x;skii et al.
Ischemia is one of the main etiological factors of stroke and is associated with the development of energy deficiency, oxidative stress, and inflammation. An abrupt restoration of blood flow, called reperfusion, can worsen the effects of is...