Brain lipid metabolism and transport: implications for neurodegeneration and therapeutic strategies: a comprehensive review [0.03%]
脑脂质代谢和运输：神经退行性病变及治疗策略的启示：全面综述
Amjad Mahmood Qadir,Rebaz Anwar Omar,Seerwan Hamadameen Sulaiman et al.
Amjad Mahmood Qadir et al.
This 2024comprehensive review examines the crucial functions of lipids in neurological health, highlighting their vital contributions to brain structure, function, and pathology. The intricate lipid composition of the brain, comprising phos...
Intelectin-1 and systemic inflammation indices as potential biomarkers in alzheimer's disease [0.03%]
脑白质高信号及认知障碍与阿尔茨海默病血浆生物标志物之间的关联性：横断面和纵向分析
Alev Lazoglu Ozkaya,Nilifer Gürbüzer,Filiz Mercantepe et al.
Alev Lazoglu Ozkaya et al.
Alzheimer's disease (AD) is a progressive neurodegenerative condition marked by amyloid-beta deposits, tau pathology, chronic systemic inflammation, and metabolic disturbances. Recent evidence highlights the relevance of inflammatory marker...
Oleuropein modulates behavioral changes, apoptosis, autophagy, inflammation, oxidative stress-associated PI3K/Akt/mTOR pathways in TAA-Induced hepatic encephalopathy [0.03%]
羟基苦参碱通过调节PI3K/Akt/mTOR信号通路对抗TAA诱导的肝性脑病中的行为改变、凋亡、自噬、炎症和氧化应激反应
Seda Yakut,Hülya Kara,Seçkin Özkanlar et al.
Seda Yakut et al.
Hepatic encephalopathy (HE), which develops as a result of liver failure, is an important neurological disorder involving inflammation and oxidative damage, with apoptosis and autophagy supported mainly by experimental evidence. In the curr...
Integrative behavioral, histological, and proteomics profiling identifies cerebellar drivers of motor dysfunction in a rat model of hepatic encephalopathy [0.03%]
整合行为学、组织学和蛋白质组学分析鉴定出肝性脑病大鼠模型中小脑运动障碍的驱动因素
Shambhu Kumar Prasad,Priyanka Thakur,Vishal Vikram Singh et al.
Shambhu Kumar Prasad et al.
Hepatic encephalopathy (HE) is a neuropsychiatric disease caused by liver failure and/or portosystemic shunting and is characterized by cognitive and motor impairments. Although it is typically thought to be reversible after liver transplan...
Paeony root prevents 6-hydroxydopamine-induced neurotoxicity by regulating autophagic dysfunction via AKT signaling in Parkinson's disease models [0.03%]
丹皮通过Akt信号通路调控自噬障碍防治帕金森病模型中6-羟多巴胺诱导的神经毒性作用
Yujin Choi,Eugene Huh,In Gyoung Ju et al.
Yujin Choi et al.
Parkinson's disease (PD) is a neurodegenerative disease that primarily affects motor function. Dopaminergic cell death occurs progressively in the PD brain and autophagic dysfunction is critically implicated in the neuronal death. Therefore...
An overview of gene and cell therapy approaches for Alzheimer's disease [0.03%]
基因和细胞疗法在阿尔茨海默病中的应用概述
Zahra Heidari,Alireza Zakaee,Asma Vafadar et al.
Zahra Heidari et al.
Alzheimer's disease (AD), acknowledged as the leading cause of dementia, is defined by the accumulation of amyloid plaques and neurofibrillary tangles (NFTs) in the brain. This condition presents a significant challenge to global health due...
Role of apolipoprotein E4 in alzheimer's disease pathogenesis and emerging therapeutic strategies [0.03%]
载脂蛋白E4在阿尔茨海默病发病机制中的作用及新兴的治疗策略
Sribha Natarajan,Saraswathy Sundara Dhakshinamurthy
Sribha Natarajan
Cross-seeding of IAPP and Aβ42: A review of the molecular link between type 2 diabetes and Alzheimer's disease [0.03%]
胰岛素样肽和Aβ42的交叉致种子作用：2型糖尿病与阿尔茨海默病之间分子联系的综述
Priyadharshine Ramesh Babu,Clayton Turner,Rebecca Ryznar
Priyadharshine Ramesh Babu
Alzheimer’s Disease (AD) and Type 2 Diabetes Mellitus (T2DM) are interconnected conditions, both marked by the aggregation of amyloidogenic proteins: amyloid-β 42 (Aβ42) in AD and islet amyloid polypeptide (IAPP) in T2DM. Emerging eviden...
Piceatannol as a multi-target neuroprotective agent: mechanistic insights and therapeutic prospects in neurological disorders [0.03%]
白杨太宁作为多靶点神经保护剂：机制见解和神经系统疾病的治疗前景
Arif Hossain,Emon Mia,Sakib Al Hasan et al.
Arif Hossain et al.
Neurological disorders like Alzheimer's, Parkinson's, and stroke involve oxidative stress and inflammation. Current treatments mainly ease symptoms but have side effects. Piceatannol, a natural polyphenol, shows promise as a safer, multi-ta...
TLRs and NLRs modulate oral microbiome involvement in Alzheimer's disease [0.03%]
Toll样受体和NOD样受体调节口腔菌群在阿尔茨海默病发病中的作用
Hossein Motevalli,Aida Mehrani,Kosar Zolfaghari et al.
Hossein Motevalli et al.
Alzheimer's disease (AD) is the most common and irreversible type of dementia, accounting for more than half of all dementia cases. Early diagnosis of AD plays a role in slowing the progression of the disease and also preserving the quality...