The impact and mechanisms of YL-IPA08, a potent ligand for the translocator protein (18 kDa) on protection against LPS-induced depression and cognitive dysfunction in rodents [0.03%]
一种新型TSPO高亲和力配体YL-IPA08对脂多糖诱导的认知损伤和抑郁样行为的保护作用及机制研究
Lin-Yu Cui,Jing-Yao Duan,Jiao-Zhao Yan et al.
Lin-Yu Cui et al.
Translocator protein (18 kDa) (TSPO) has been implicated in the development of depression and cognitive dysfunction. This study aimed to investigate the anti-depression/anti-anxiety and cognitive enhancing impacts and potential mechanisms o...
Astaxanthin nanoemulsion improves cognitive function and synaptic integrity in Streptozotocin-induced Alzheimer's disease model [0.03%]
虾青素纳米乳改善链佐星诱导的阿尔茨海默病模型中的认知功能和突触完整性
Mazzura Wan Chik,Meor Mohd Redzuan Meor Mohd Affandi,Nurul Aqmar Mohd Nor Hazalin et al.
Mazzura Wan Chik et al.
Astaxanthin derived from natural sources has excellent antioxidant and anti-inflammatory effects, and it is currently being widely researched as a neuroprotectant. However, astaxanthin possesses low oral bioavailability, and thus, astaxanth...
Edaravone dextranol alleviates ferroptosis, Cuproptosis, and blood-brain barrier damage after acute cerebral infarction [0.03%]
艾达溶右旋糖减轻急性脑梗死后铁死亡、铜死亡和血脑屏障损伤
Guimin Jin,Wei Han,Tingting Duan et al.
Guimin Jin et al.
Edaravone dextrose (EDB) is a commonly used clinical treatment for cerebral infarction due to its anti-inflammatory and free radical scavenging properties. However, its potential additional neuroprotective mechanisms need to be further inve...
Correction to: Anti-inflammatory, anti-apoptotic, and neuroprotective potentials of anethole in Parkinson's disease-like motor and non-motor symptoms induced by rotenone in rats [0.03%]
纠正：茴香脑在轮船菌素诱导的帕金森病大鼠模型中对抗炎、抗凋亡和神经保护潜能的研究
Sadegh Moradi Vastegani,Seyed Esmaeil Khoshnam,Esrafil Mansouri et al.
Sadegh Moradi Vastegani et al.
Published Erratum
Metabolic brain disease. 2025 Mar 3;40(3):135. DOI:10.1007/s11011-025-01547-4 2025
Combined treatment of Ketogenic diet and propagermanium reduces neuroinflammation in Tay-Sachs disease mouse model [0.03%]
生酮饮食和丙戊锗联合治疗可降低Tay-Sachs疾病小鼠模型中的神经炎症
Orhan Kerim Inci,Volkan Seyrantepe
Orhan Kerim Inci
Tay-Sachs disease is a rare lysosomal storage disorder caused by β-Hexosaminidase A enzyme deficiency causing abnormal GM2 ganglioside accumulation in the central nervous system. GM2 accumulation triggers chronic neuroinflammation due to n...
Unveiling the mTOR pathway modulation by SGLT2 inhibitors: a novel approach to Alzheimer's disease in type 2 diabetes [0.03%]
SGLT2抑制剂对mTOR途径的调节作用揭幕：二型糖尿病中阿尔茨海默病的新疗法
Prakash Ramakrishan,Jayaraman Rajangam,Shaheedha Shabudeen Mahinoor et al.
Prakash Ramakrishan et al.
Alzheimer's disease (AD) is a neurological condition causing cognitive deterioration, leading to severe consequences. As the global prevalence of AD increases, new treatment approaches are needed to supplement current conventional therapies...
Pharmacological modulation of PI3K/PTEN/Akt/mTOR/ERK signaling pathways in ischemic injury: a mechanistic perspective [0.03%]
缺血损伤中PI3K/PTEN/Akt/mTOR/ERK信号通路的药理学调节：机制分析视角
Heena Khan,Aditi Singh,Yashvardhan Singh et al.
Heena Khan et al.
Ischemia, also known as ischemia, relates to the reduced blood movement to a cells, muscle group, or organ in the body, culminating in an insufficient amount of oxygen required for cellular metabolism and the maintenance of tissue viability...
Untargeted metabolomics unveils critical metabolic signatures in novel phenotypes of acute ischemic stroke [0.03%]
非靶向代谢组学揭示急性缺血性卒中新表型的关键代谢特征
Yao Jiang,Qian Wu,Yingqiang Dang et al.
Yao Jiang et al.
This study aimed to identify metabolic footprints associated with distinct phenotypes of acute ischemic stroke (AIS) using untargeted metabolomics. We included 20 samples each from AIS phenotype A (n = 251), B (n = 213), and C (n = 43) grou...
Lights and shadows of clozapine on the immune system in schizophrenia: a narrative literature review [0.03%]
抗精神病药物对免疫系统的影响：叙事性文献回顾中的氯氮平的光明与阴影
Jian Liu,Weimin Zhao,Yitong Wang
Jian Liu
Schizophrenia is a chronic mental disorder and one of the main causes of disability in the world. Approximately 1% of the general population suffers from this disorder, and almost 30% of cases are unresponsive to antipsychotic therapies. Cl...
α-asarone activates mitophagy to relieve diabetic encephalopathy via inhibiting apoptosis and oxidative stress [0.03%]
α-asarone通过抑制凋亡和氧化应激激活线粒体自噬从而缓解糖尿病性脑病
Xiao-Dan Yan,Rong-Hua Fan,Yu Wang et al.
Xiao-Dan Yan et al.
Diabetic encephalopathy (DE) is a common complication of diabetes that may result in cognitive impairment. Currently, there is limited effective therapy for DE. Herein, we explored the beneficial effect of α-Asarone on DE and its potential...