Tryptophan metabolism alterations in neurological and psychiatric diseases: Molecular mechanisms and pharmacological targets [0.03%]
色氨酸代谢在神经精神疾病中的改变：分子机制和药理靶点
Yuanyuan Wang,Yuling Chen,Hongtao Li et al.
Yuanyuan Wang et al.
Tryptophan (TRP) is an essential amino acid required for protein synthesis. It undergoes an extensive and complex metabolism through three pathways, the kynurenine pathway (KP), the serotonin pathway (SP), and the indole pathway (IP), resul...
Metabolic dysregulation in psychotic mania: longitudinal cardiometabolic changes with exploratory analyses of serum uric acid [0.03%]
代谢紊乱与精神病性躁狂：纵向的心血管及代射变化和血清尿酸的探索性分析
Shariq Qureshi,Mohammed Qutishat,Ahmed Al-Huseini et al.
Shariq Qureshi et al.
MiR-122 activates PI3K/Akt signaling to suppress microglial activation and ferroptosis in ischemic brain injury [0.03%]
miR-122通过激活PI3K/AKT信号通路抑制缺血性脑损伤中的小胶质细胞活化和铁死亡现象
Weifeng Shan,Haiyan Lan,Yini Wu et al.
Weifeng Shan et al.
Role of insulin-like growth factor-1/2 and related signaling in parkinson's disease [0.03%]
胰岛素样生长因子-1/2及相关信号转导在帕金森病中的作用
Emad Manni,Hayder M Al-Kuraishy,Thabat J Al-Maiahy et al.
Emad Manni et al.
Beyond mobility: A prospective study on diet and metabolism in hereditary spastic paraplegia [0.03%]
超越运动障碍：遗传性痉挛性截瘫的饮食与代谢前瞻性研究
Christina Erhardt,Imke T Spatz,Hans J Herrmann et al.
Christina Erhardt et al.
Metabolism plays an important role in neurodegenerative diseases. Hereditary spastic paraplegias (HSP) are a heterogeneous group of rare genetic neurodegenerative disorders, commonly characterized by the clinical syndrome of progressive low...
Post-translational modifications in alzheimer's disease: proteome dynamics and emerging therapeutic strategies [0.03%]
阿尔茨海默病中的翻译后修饰：蛋白质组动力学和新兴的治疗策略
Shareen Singh,Amritpal Kaur,Souvik Banerjee et al.
Shareen Singh et al.
Adiponectin in neuroinflammation and parkinson's disease: A macromolecular and therapeutic perspective [0.03%]
脂联素在神经炎症和帕金森病中的作用：宏分子及治疗学视角
Kanupriya Chauhan,Mayur Porwal,Shamsher Singh
Kanupriya Chauhan
Parkinson's Disease (PD) is a neurodegenerative disorder that exacerbates over time and is the result of long-term neuroinflammation and the degeneration of dopaminergic neurons. New research shows that adiponectin, an adipokine with strong...
The relationship between gut microbiota and neurodegenerative diseases: a genetic and epigenetic perspective [0.03%]
肠道微生物与神经退行性疾病的关系：基因和表观遗传学视角
Zeynep Betül Altan,Murat Ihlamur
Zeynep Betül Altan
Gut microbiota (GM) is a complex and dynamic structure that can have a wide range of effects on human health. Studies in recent years have shown that microbiota is not only related to the gastrointestinal tract (GIT) but also to the immune ...
Kinetin mitigate neurodegenerative damage of Alzheimer induced by beta-amyloid in male rats by antioxidant and antithrombotic effects [0.03%]
植株愈伤组织素通过抗氧化和抗凝作用减轻雄性大鼠由阿尔茨海默氏病诱导的β淀粉样蛋白神经退行性损伤
Soroush Movaffagh,Mahin Behzadifard,Mehrnoush Moghaddasi et al.
Soroush Movaffagh et al.
Intrathecal delivery of AAVrh10-mHexa combined with anti-inflammatory treatment reduces neuropathological markers and extends the lifespan of mice with early-onset Tay-Sachs disease [0.03%]
AAVrh10-mHexa鞘内递送联合抗炎治疗可减少早期婴儿型泰-萨克斯病小鼠模型的病理改变并延长其生存期
Melike Can,Jerome Ausseil,Volkan Seyrantepe
Melike Can
Tay-Sachs disease is a lysosomal storage disorder caused by mutations in the HEXA gene, which encodes the α-subunit of β-hexosaminidase A-an enzyme that breaks down GM2 ganglioside. Recently, a mouse model of Tay-Sachs, the DKO, with defi...