Hydroxysafflower yellow A alleviates the inflammatory response in astrocytes following cerebral ischemia by inhibiting the LCN2/STAT3 feedback loop [0.03%]
羟基红花黄色素A通过抑制LCN2/STAT3反馈回路缓解脑缺血后星形胶质细胞的炎症反应
Lijuan Song,Yige Wu,Lijun Yin et al.
Lijuan Song et al.
Lipocalin-2 (LCN2), an acute phase protein mainly expressed in astrocytes (Ast), is closely related to the production of inflammatory cytokines following ischemic stroke. During the pathophysiological process of ischemic stroke, the Janus k...
Ferroptosis and Alzheimer's: unveiling new avenues for the treatment and prevention [0.03%]
铁死亡与阿尔茨海默病：揭示治疗和预防的新途径
Veerta Sharma,Prateek Sharma,Thakur Gurjeet Singh
Veerta Sharma
Alzheimer's disease (AD), one of the most prevalent neurodegenerative illnesses worldwide, has a devastating effect on individual, families and society. Despite the extensive research and effort, various clinical trials aimed against amyloi...
Ursolic acid derivatives improved clinical signs of experimental autoimmune encephalomyelitis by modulating central nervous system inflammation [0.03%]
乌索酸衍生物通过调节中枢神经系统的炎症改善实验性自身免疫性脑脊髓炎的临床症状
Elaine Carlos Scherrer,Karla Antunes Ramos,Ydia Mariele Valadares et al.
Elaine Carlos Scherrer et al.
The immunopathogenesis of multiple sclerosis (MS) involves the activation of T lymphocytes, leading to progressive axonal loss and brain atrophy. Ursolic acid (AU) has been widely used as an herbal medicine, with the ability to inhibit the ...
The beneficial effects of D-allose and D-allulose on the brain under ischemic stroke and obese-insulin resistant conditions: evidence from in vitro to clinical studies [0.03%]
D-阿洛糖和D-psicose对脑缺血中风和肥胖胰岛素抵抗条件下的有益影响：从体外到临床研究的证据
Yanmei Huang,Chanisa Thonusin,Masaaki Tokuda et al.
Yanmei Huang et al.
Ischemic stroke, and obese-insulin resistance are common pathological conditions that lead to brain injury, resulting in neurodegeneration, brain atrophy, and cognitive dysfunction. Rare sugars, which are scarce monosaccharide in nature, ha...
Protective effects of alpha-lipoic acid on memory deficit induced by repeated doses of solifenacin in mice: the role of nitro-oxidative stress [0.03%]
α硫辛酸对索利那新引起的记忆力损伤的保护作用：硝化氧化应激的作用
Leonardo Pimentel Dantas,Emanuel Carneiro de Vasconcelos,Carla da Silva Cunha et al.
Leonardo Pimentel Dantas et al.
Solifenacin (Sol) is one of the most used antimuscarinics for the treatment of bladder dysfunction and there are no conclusive studies on its effects on learning and memory after long-term use. Since substances with antioxidant action, such...
Amomum tsao-ko crevost et lemaire ameliorates depression-like behaviors and hippocampal inflammation by inhibiting microglia activation and HMGB1/TLR4/NF-κB pathway in diabetic mice with depression [0.03%]
茨实抑制微胶质细胞活化和HMGB1/TLR4/NF-κB通路改善糖尿病伴抑郁小鼠的类抑郁行为及海马炎症反应
Zhen Wang,Huilin Ren,Caixia Wang et al.
Zhen Wang et al.
Diabetic depression may be closely related to hippocampal inflammation. We hypothesized that Amomum tsao-ko Crevost et Lemaire (A. tsao-ko) might ameliorate depression-like behavior and glucose intolerance by modulating hippocampal inflamma...
Sex-specific modulation of FOLR1 and its cycle enzyme genes in Alzheimer's disease brain regions [0.03%]
阿尔茨海默病脑区中FOLR1及其循环酶基因的性别特异性调节
Cristina Sanfilippo,Paola Castrogiovanni,Rosa Imbesi et al.
Cristina Sanfilippo et al.
Alzheimer's disease (AD) is the most common form of dementia, characterized by progressive cognitive and functional decline. Its incidence increases significantly with age and is more prevalent in women than men. We investigated the folate ...
Luteolin ameliorates ischemic/reperfusion injury by inhibiting ferroptosis [0.03%]
rutin通过抑制铁死亡改善缺血/再灌注损伤
Hua Li,Jin-Xia Li,Yi-di Zeng et al.
Hua Li et al.
Ischaemic stroke is a large disease burden worldwide. Thrombolysis and thrombectomy are the main treatment methods for cerebral ischemia-reperfusion (I/R) injury. Luteolin, as a flavonoid compound, has an antagonistic effect on inflammation...
Artesunate alleviated hippocampal neuron pyroptosis by down-regulating NLRP3 in rats with cerebral small vessel disease [0.03%]
青蒿琥酯通过下调NLRP3减轻脑小血管病大鼠海马神经元焦亡
Xiaokun Wang,Hequan Zhong,Xiangyu Kong et al.
Xiaokun Wang et al.
Our study aims to investigate the potential of artesunate (ART) in improving learning and memory function by down-regulating NLRP3 and consequently affecting pyroptosis levels in the brains of rats with cerebral small vessel disease (CSVD)....
Pharmacologically activating BDNF/TrkB signaling exerted rapid-acting antidepressant-like effects through improving synaptic plasticity and neuroinflammation [0.03%]
药理激活BDNF/TrkB信号通过改善突触可塑性和神经炎症产生快速抗抑郁作用
Si-Rui Sun,Jia-Ning Zhao,Peng-Wei Bi et al.
Si-Rui Sun et al.
BDNF (Brain-derived neurotrophic factor)/TrkB (tropomyosin receptor kinase B) signaling has great therapeutic potential for depression, but the underlying mechanism remains unclear. This study aims to investigate the molecular mechanism und...