Beyond mobility: A prospective study on diet and metabolism in hereditary spastic paraplegia [0.03%]
超越运动障碍：遗传性痉挛性截瘫的饮食与代谢前瞻性研究
Christina Erhardt,Imke T Spatz,Hans J Herrmann et al.
Christina Erhardt et al.
Metabolism plays an important role in neurodegenerative diseases. Hereditary spastic paraplegias (HSP) are a heterogeneous group of rare genetic neurodegenerative disorders, commonly characterized by the clinical syndrome of progressive low...
Post-translational modifications in alzheimer's disease: proteome dynamics and emerging therapeutic strategies [0.03%]
阿尔茨海默病中的翻译后修饰：蛋白质组动力学和新兴的治疗策略
Shareen Singh,Amritpal Kaur,Souvik Banerjee et al.
Shareen Singh et al.
Adiponectin in neuroinflammation and parkinson's disease: A macromolecular and therapeutic perspective [0.03%]
脂联素在神经炎症和帕金森病中的作用：宏分子及治疗学视角
Kanupriya Chauhan,Mayur Porwal,Shamsher Singh
Kanupriya Chauhan
Parkinson's Disease (PD) is a neurodegenerative disorder that exacerbates over time and is the result of long-term neuroinflammation and the degeneration of dopaminergic neurons. New research shows that adiponectin, an adipokine with strong...
The relationship between gut microbiota and neurodegenerative diseases: a genetic and epigenetic perspective [0.03%]
肠道微生物与神经退行性疾病的关系：基因和表观遗传学视角
Zeynep Betül Altan,Murat Ihlamur
Zeynep Betül Altan
Gut microbiota (GM) is a complex and dynamic structure that can have a wide range of effects on human health. Studies in recent years have shown that microbiota is not only related to the gastrointestinal tract (GIT) but also to the immune ...
Kinetin mitigate neurodegenerative damage of Alzheimer induced by beta-amyloid in male rats by antioxidant and antithrombotic effects [0.03%]
植株愈伤组织素通过抗氧化和抗凝作用减轻雄性大鼠由阿尔茨海默氏病诱导的β淀粉样蛋白神经退行性损伤
Soroush Movaffagh,Mahin Behzadifard,Mehrnoush Moghaddasi et al.
Soroush Movaffagh et al.
Intrathecal delivery of AAVrh10-mHexa combined with anti-inflammatory treatment reduces neuropathological markers and extends the lifespan of mice with early-onset Tay-Sachs disease [0.03%]
AAVrh10-mHexa鞘内递送联合抗炎治疗可减少早期婴儿型泰-萨克斯病小鼠模型的病理改变并延长其生存期
Melike Can,Jerome Ausseil,Volkan Seyrantepe
Melike Can
Tay-Sachs disease is a lysosomal storage disorder caused by mutations in the HEXA gene, which encodes the α-subunit of β-hexosaminidase A-an enzyme that breaks down GM2 ganglioside. Recently, a mouse model of Tay-Sachs, the DKO, with defi...
Environmental metals, prostaglandin pathways, and immune-mediated neuroinflammation in autism spectrum disorder: A secondary analysis of peripheral biomarker studies [0.03%]
自闭症谱系障碍中的环境金属、前列腺素通路和免疫介导的神经炎症：外周生物标志物研究的二次分析
Geir Bjørklund,Leonard Gurgas,Tony Hangan
Geir Bjørklund
Human serum hypoxanthine as a biomarker to predict recurrent major depressive disorder: a cross-sectional metabolomic study [0.03%]
人类血清次黄嘌呤作为生物标志物预测复发性重大抑郁症的横断面代谢组学研究
Yeeun Yun,Seungyeon Lee,Sora Mun et al.
Yeeun Yun et al.
Major depressive disorder (MDD) is a multifactorial and highly recurrent illness. Patients are typically required to take antidepressants for 6-12 months following a single depressive episode, even if symptoms are alleviated. However, some ...
The role of gut dysbiosis in Parkinson's disease: pathophysiology, epidemiology, and emerging therapeutic strategies [0.03%]
肠道菌群失调在帕金森病中的作用：病理生理学、流行病学及新兴的治疗策略
Zoe Peltz,Roxanne Wiblin,Varunya M Kattunga et al.
Zoe Peltz et al.
Neuro-renin-angiotensin-aldosterone system axis in alzheimer's disease: from molecular dysregulation to therapeutic redirection [0.03%]
阿尔茨海默病中的神经肾素血管紧张素醛固酮轴：从分子调节异常到治疗策略的转换
Gursimran Singh,Kousik Maparu,Khadga Raj Aran
Gursimran Singh
Alzheimer's disease (AD) is characterized by progressive neurodegeneration marked by tau hyperphosphorylation, amyloid-beta (Aβ) buildup, neuroinflammation, and blood-brain barrier (BBB) dysfunction. Although much attention is paid to unde...