Astrocytes in maintaining neuronal health and brain function: interplay of aging, diet, and environment [0.03%]
衰老、饮食和环境对神经元健康及大脑功能的 astrocyte 作用机制及其相互作用
Yulia Dembitskaya,Alexander Popov
Yulia Dembitskaya
Astrocytes are pivotal modulators of neuronal health and brain function through their roles in metabolic support, synaptic regulation, neurotransmitter recycling, and the maintenance of the blood-brain barrier. However, aging and environmen...
Spatial metabolomics reveals the effects of Acanthopanax senticosus on region-specific alterations in neurotransmitters and metabolites levels in the brains of α-syn transgenic Parkinson's disease model mice [0.03%]
基于空间代谢组学技术揭示刺五加对α-突触核蛋白PD模型小鼠脑内区特异性神经递质及小分子代谢物的影响作用研究
Qi Zheng,Yi Lu,Donghua Yu et al.
Qi Zheng et al.
Acanthopanax senticosus (Rupr. et. Maxim.) Harms (ASH), a widely used traditional Chinese herbal medicine, possesses various therapeutic effects, such as the ability to tonify the spleen and kidney, strengthen muscles and bones, and promote...
SOCS2 alleviates traumatic brain injury-induced mitochondrial damage and parthanatos in endothelial cells by inhibiting the JAK2/STAT3 signaling pathway [0.03%]
SOCS2通过抑制JAK2/STAT3信号通路缓解内皮细胞中创伤性脑损伤诱导的线粒体损伤和PARP依赖性细胞死亡
Hao Zhang,Yang Gui,Wuqiang Che et al.
Hao Zhang et al.
Background: Traumatic brain injury (TBI) is an important cause of death and disability worldwide. Vascular endothelial cells (ECs) injury has been confirmed to be a risk factor for the development of severe sequelae of TB...
Gut microbiota reconstitution and control of α-synucleinopathy with β-glucans: a promising approach for individuals with parkinson's disease [0.03%]
β-葡聚糖重塑肠道菌群并控制α-突触核蛋白病：帕金森病患者的潜在新策略
Faezeh Hatami,Zahra Aghelan,Mahan Rezaie Pouya et al.
Faezeh Hatami et al.
Parkinson's disease (PD) ranks as the second most prevalent neurodegenerative condition affecting individuals in their middle age and beyond. Its hallmark features include the abnormal accumulation of α-synuclein protein and the progressiv...
Protective and therapeutic effects of betanin nanoparticles in an alzheimer's rat model: modulation of behavior and expression of AQP4, BDNF, SIRT6, and Seladin-1 [0.03%]
甜菜碱纳米颗粒在阿尔茨海默病大鼠模型中的保护和治疗作用：行为及AQP4、BDNF、SIRT6和Seladin-1表达的调节作用
Nasim Abedimanesh,Seyed Alireza Miri,Ali Mohammadi et al.
Nasim Abedimanesh et al.
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by cognitive decline, oxidative stress, and neuroinflammation. Betanin, a natural antioxidant, has shown neuroprotective potential, but its clinical use is limited by po...
Promotion of angiogenesis in cerebral infarction by Tongqiao Huoxue Decoction through activation of glycolysis [0.03%]
通窍活血汤促进脑梗塞新生血管生成的机制研究：激活糖酵解途径诱导内皮细胞增殖与迁移的作用及意义
Xintong Li,Rui Zhang,Gongda Li et al.
Xintong Li et al.
Angiogenesis plays a critical role in mitigating cerebral infarction injury. However, both endogenous and exogenous angiogenic responses are often insufficient to generate stable, functional blood vessels. Brain microvascular endothelial ce...
Ranolazine neuroprotection against middle cerebral artery occlusion/reperfusion ischemic injury via modulation of brain-derived neurotrophic factor and brain mitochondrial tu translation elongation factor (TUFM) [0.03%]
雷诺嗪通过调节脑源性神经营养因子和脑线粒体翻译延长因子(TUFM)对大脑中动脉闭塞/再灌注缺血损伤的神经保护作用研究
Mohammad Aquib Siddiqui,Abhishek Pathak,Kakarla Ramakrishna et al.
Mohammad Aquib Siddiqui et al.
The present study investigates the therapeutic potential of Ranolazine in cerebral ischemic stroke, focusing on its neuroprotective properties in a middle cerebral artery occlusion/reperfusion (MCAO/R) induced ischemic brain injury in a rat...
Alterations in serum nudifloramide associated with response to diverse pharmacological treatments in major depressive disorder: a preliminary study [0.03%]
血清nudifloramide水平与抑郁症抗抑郁药物治疗效应的关联性研究
Seungyeon Lee,Doojin Kim,Hee-Gyoo Kang et al.
Seungyeon Lee et al.
Pharmacological treatments for major depressive disorder (MDD) have limited efficacy, underscoring the need for biomarkers to assess treatment response. Metabolomics enables characterization of metabolic alterations associated with antidepr...
Mushrooms for the brain: A review of the neuroprotective effects of mushroom bioactive compounds [0.03%]
助脑蘑菇：蘑菇生物活性化合物神经保护作用综述
Tamilselvan Amutha Gokul,Kamatchi Ramesh Kumar,Mani Rama Prabha et al.
Tamilselvan Amutha Gokul et al.
Neurodegenerative and neuropsychiatric diseases pose significant challenges to individuals' well-being and healthcare systems. These conditions share common mechanisms like oxidative stress, protein aggregation, inflammation, impaired neuro...
Differential effects of hypothermia and memantine in neonatal hypoxia-ischemia [0.03%]
低温和美金刚胺在新生儿缺氧缺血中的不同作用效果
Francielle Fernandes Spies,Ricardo Ribeiro Nunes,Isadora D&#x;Avila Tassinari et al.
Francielle Fernandes Spies et al.
Therapeutic hypothermia (TH) is the standard treatment for neonatal hypoxia-ischemia (HI), but its efficacy is limited. Understanding the molecular pathways involved in cell death and survival, while considering sex-related differences, is ...