Low carbohydrate and low-calorie diets reduce liver fat and lower brain glutamate and myo-inositol levels in patients with Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) [0.03%]
低碳水化合物和低热量饮食可减少代谢功能异常相关肝脂肪变性疾病患者的肝脏脂肪并降低大脑谷氨酸和肌醇水平
Andreana P Haley,Jack Knight-Scott,Marie Caillaud et al.
Andreana P Haley et al.
In a longitudinal cohort study with intervention (NCT05216796), we utilized multiorgan imaging to determine if metabolic dysfunction-associated steatotic liver disease (MASLD) is associated with elevated cerebral glutamate and myo-inositol ...
Metabolic dysregulation in amyotrophic lateral sclerosis: insights from 1H NMR-based metabolomics in a tertiary care center in India [0.03%]
基于印度三级护理中心的~(1)H NMR代谢组学在肌萎缩侧索硬化代谢调控中的研究见解
Priyanka Gautam,Rahul Yadav,Ranjeet Kumar Vishwakarma et al.
Priyanka Gautam et al.
Amyotrophic Lateral Sclerosis (ALS) is a progressive neurodegenerative disorder characterized by motor neuron loss, leading to severe physical impairment and mortality. Despite available treatments like Riluzole and Edaravone, their limited...
A second act for spironolactone: cognitive benefits in renal dysfunction - a critical review [0.03%]
螺内酯的认知益处：肾功能不全患者的回顾性研究
Akhil Sharma,Ashi Mannan,Shareen Singh et al.
Akhil Sharma et al.
Renal dysfunction or Chronic kidney disease (CKD) are increasingly associated with cognitive deficit and memory impairment, suggesting a crucial kidney-brain axis. This review examines spironolactone's emerging role as a neuroprotective age...
Hydroxymethyltransferase 2 promotes the development of glioblastoma by mediating WTAP regulation of PTEN N6-methyladenosine modification [0.03%]
二羟甲基转移酶2通过介导WTAP调控PTEN N6-甲基腺苷修饰促进胶质母细胞瘤的发生发展
Meng Wang,Guangwei Sun,Yongzhong Fan et al.
Meng Wang et al.
Characterized by rapid proliferation and therapeutic resistance, glioblastoma (GBM) represents the deadliest primary CNS neoplasm, demonstrating a low survival rate and high mortality rate in patients. This is mainly related to the developm...
Genotypic and phenotypic characteristics of Turkish patients with phenylalanine metabolism disorders [0.03%]
土耳其高苯氨酸血症患者的基因型和表型特征分析
Fatma-Nur Kuzucu,Mustafa Kilic,Abdullah Sezer et al.
Fatma-Nur Kuzucu et al.
Phenylketonuria (PKU) is an autosomal recessive disorder of phenylalanine metabolism, in which especially high phenylalanine concentrations cause brain dysfunction. If untreated, this brain dysfunction results in severe intellectual disabil...
Urea cycle defects in adulthood: clinical presentation, diagnosis and treatment in genetically encoded hepatic metabolic disorders with a potential for encephalopathy [0.03%]
成人尿素循环缺陷的临床表现、诊断和治疗：遗传性肝脏代谢紊乱及其潜在脑病患者的治疗方案
Anibh Martin Das
Anibh Martin Das
Hyperammonaemia is an important cause for encephalopathy. Ammonia is the waste product of amino acid degradation and cannot be excreted via urine. Ammonia is metabolized to water-soluble urea via the urea cycle. Hyperammonaemia not only occ...
The impact of modafinil on memory and brain oxidative stress: contrasting effects of acute and chronic administration in healthy rats [0.03%]
莫达非尼对健康大鼠记忆和脑氧化应激的影响：急性给药与慢性给药的对比研究
Jorge M Aguiar-Geraldo,Bruno Spalenza da Silva,Taise Possamai-Della et al.
Jorge M Aguiar-Geraldo et al.
The present study assessed the impact of modafinil (MD) on memory function and oxidative damage in the brains of naive rats. Wistar rats were administered either a single dose or repeated doses (over 30 days) of water or MD (75, 150, or 300...
Faeze Kachoueiyan,Niosha Yahyavi Kalkhoran,Anousha Yahyavi Kalkhoran et al.
Faeze Kachoueiyan et al.
Alzheimer's disease (AD), a prevalent neurodegenerative disorder, represents a significant global health challenge, characterized by cognitive decline and neuroinflammation. Recent investigations have highlighted the critical role of the gu...
A network pharmacology-based approach to decipher the pharmacological mechanisms of Salvia officinalis in neurodegenerative disorders [0.03%]
基于网络药理学的解译机制的方法萨伐叶 officinalis 神经退行性疾病中的药理学 механиз.ms 的方法
Sheikh Sana Nazir,Divya Goel,Divya Vohora
Sheikh Sana Nazir
The present study aimed to assess the pharmacological mechanism of Salvia officinalis in Neurodegenerative disorders using a network pharmacology approach followed by molecular docking analysis. Phytoconstituents of S.officinalis were obtai...
Neuroprotective potential of hispidulin and diosmin: a review of molecular mechanisms [0.03%]
hispidulin和diosmin的神经保护潜力：分子机制综述
Anish Singh,Lovedeep Singh,Diksha Dalal
Anish Singh
Flavonoids are an important class of natural products, particularly, belong to a class of plant secondary metabolites having a polyphenolic structure. They are widely found in fruits, vegetables, and certain beverages. Hispidulin and diosmi...