Inhibition of ventral tegmental area projections to the paraventricular thalamus attenuates conditioned cues-induced heroin seeking behavior in rats [0.03%]
抑制腹侧被盖区投射到视上结节核团的神经纤维可以减弱可卡因复吸行为
Yiying Zhou,Wenchang Li,Dandan Cai et al.
Yiying Zhou et al.
Ventral tegmental area (VTA) is typically involved in heroin reward, but it is still unclear whether the VTA or neural projections containing VTA are also involved in conditioned cues (CS)-induced heroin-seeking behavior. In present study, ...
Ketamine enhances neurological function through neuronal and plasticity-related protein changes in rats with permanent middle cerebral artery occlusion [0.03%]
氯胺酮通过改善永久性大脑中动脉闭塞大鼠神经蛋白表达增强其神经功能
Nestor I Martínez-Torres,Jhonathan Cárdenas-Bedoya,Blanca Miriam Torres-Mendoza
Nestor I Martínez-Torres
Ketamine (KET) is a drug that has been used as an anesthetic for many years. However, in the last two decades, new properties have been discovered that make it useful in treating various psychiatric and neurological disorders. Ketamine has ...
Polygalasaponin F alleviates cerebral ischemia-reperfusion injury through inhibiting mitophagy [0.03%]
聚гал拉 sapogenin F通过抑制线粒体自噬来缓解脑缺血再灌注损伤
Siqi Quan,Roujia Guo,Jingjing Bu et al.
Siqi Quan et al.
Neurological recovery after ischemic stroke (IS) remains clinically challenging, primarily due to cerebral ischemia-reperfusion injury (CIRI). Oxidative stress contributes to the pathogenesis of CIRI by causing reactive oxygen species exces...
Protective effect of fisetin alone and in combination with lactobacillus using experimental model of diabetes associated cognitive impairment in rats [0.03%]
檞皮素及联合乳杆菌对糖尿病认知功能障碍大鼠的保护作用研究模型
Kousik Maparu,Shamsher Singh
Kousik Maparu
Type 2 diabetes mellitus (T2DM), which occurs due to frequent consumption of a high-fat diet (HFD), is recognized as a significant risk factor for progressive cognitive decline. The present study investigates the potential neuroprotective e...
Minocycline inhibits microglial activation and mitigates compulsive and anxiety-like behaviors induced by a high-refined carbohydrate diet in male BALB/c mice [0.03%]
多西环素通过抑制小胶质细胞活化改善BALB/c雄性小鼠高 refined 单糖西饮食诱导的强迫行为和类焦虑行为
Nícia Pedreira Soares,Anna Paula Marçal,Amanda Carla Oliveira et al.
Nícia Pedreira Soares et al.
Consumption of a high-carbohydrate (HC) diet, which is commonly associated with obesity, has been linked to anxiety-like and compulsive behaviors. This association is predominantly attributed to chronic low-grade inflammation, which affects...
Oxymatrine possibly inhibits differentiation and maturation of oligodendrocytes in the remyelination of the toxin-induced demyelination animal model [0.03%]
氧化苦参碱通过抑制脱髓鞘后少突胶质细胞的分化、成熟而影响再生修复
Mei Li,Fei Huang,Jian Song et al.
Mei Li et al.
Multiple sclerosis (MS) is characterized by demyelination. In demyelinated MS lesions, the recruitment, differentiation, and maturation of oligodendrocyte progenitor cells (OPCs) into oligodendrocytes (OLGs) are inhibited, leading to remyel...
Synbiotic laden with Faecalibacterium prausnitzii, fructooligosaccharides, and galactooligosaccharides mitigates quinpirole-induced OCD-like symptoms in rats [0.03%]
富含Faecalibacterium prausnitzii、低聚果糖和半乳糖低聚糖的合成益生菌可减轻喹吡醇诱导的大鼠OCD样症状
Sonali R Kamble,Km Neha Sharma,Hara Prasad Padhy et al.
Sonali R Kamble et al.
Obsessive-compulsive disorder (OCD) is a mental illness of unwanted recurrent thoughts and compulsive behaviors. The significance of the microbiota-gut-brain axis has been increasingly documented in the manifestation of neuropsychiatric dis...
Astrocytes in maintaining neuronal health and brain function: interplay of aging, diet, and environment [0.03%]
衰老、饮食和环境对神经元健康及大脑功能的 astrocyte 作用机制及其相互作用
Yulia Dembitskaya,Alexander Popov
Yulia Dembitskaya
Astrocytes are pivotal modulators of neuronal health and brain function through their roles in metabolic support, synaptic regulation, neurotransmitter recycling, and the maintenance of the blood-brain barrier. However, aging and environmen...
Spatial metabolomics reveals the effects of Acanthopanax senticosus on region-specific alterations in neurotransmitters and metabolites levels in the brains of α-syn transgenic Parkinson's disease model mice [0.03%]
基于空间代谢组学技术揭示刺五加对α-突触核蛋白PD模型小鼠脑内区特异性神经递质及小分子代谢物的影响作用研究
Qi Zheng,Yi Lu,Donghua Yu et al.
Qi Zheng et al.
Acanthopanax senticosus (Rupr. et. Maxim.) Harms (ASH), a widely used traditional Chinese herbal medicine, possesses various therapeutic effects, such as the ability to tonify the spleen and kidney, strengthen muscles and bones, and promote...
SOCS2 alleviates traumatic brain injury-induced mitochondrial damage and parthanatos in endothelial cells by inhibiting the JAK2/STAT3 signaling pathway [0.03%]
SOCS2通过抑制JAK2/STAT3信号通路缓解内皮细胞中创伤性脑损伤诱导的线粒体损伤和PARP依赖性细胞死亡
Hao Zhang,Yang Gui,Wuqiang Che et al.
Hao Zhang et al.
Background: Traumatic brain injury (TBI) is an important cause of death and disability worldwide. Vascular endothelial cells (ECs) injury has been confirmed to be a risk factor for the development of severe sequelae of TB...