7-chloro-4-(phenylselanyl) quinoline (4-PSQ) modulates biochemical and behavioral adaptations during the early developmental stage of a post-traumatic stress disorder (PTSD) model in mice [0.03%]
7-氯-4-(苯硒基)喹啉（4-PSQ）调节小鼠 PTSD 模型早期发育阶段的生化和行为适应性反应
Carolina C Martins,Angélica S Reis,Ketlyn P da Motta et al.
Carolina C Martins et al.
The neuroprotective effects of 7-chloro-4-(phenylselanyl) quinoline (4-PSQ) have been reported in experimental models of central nervous system (CNS) disorders due to its multi-target actions. Considering the limited efficacy of current tre...
Dexmedetomidine alleviates ferroptosis caused by traumatic brain injury via the NRF2/HO-1/GPX4 pathway [0.03%]
右美托咪定通过NRF2/HO-1/GPX4信号通路缓解创伤性脑损伤引起的铁死亡
Jin-Jing Hao,Xue-Lian Fang,Yi-Yang Chen et al.
Jin-Jing Hao et al.
Emerging evidence suggests that TBI triggers ferroptosis, and dexmedetomidine (Dex) has a neuroprotective effect. This study aimed to explore the underlying mechanism of function of Dex in ferroptosisi after TBI. TBI model was established u...
miRNA dysregulation in depression: unraveling the interplay between neuroplasticity, HPA axis dysfunction, and neuroinflammation [0.03%]
抑郁症中miRNA失调：揭示神经可塑性、HPA轴功能障碍和神经炎症之间的相互作用
Reda M Mansour,Nehal I Rizk,Sherif S Abdel Mageed et al.
Reda M Mansour et al.
Major depressive disorder (MDD) is a common psychiatric illness with chronic poor mood, cognitive impairment, and neurovegetative symptoms. Genetic, environmental, and neurochemical variables are involved. A recent study shows that microRNA...
Ferroptosis-inducing effects of cromolyn in microglia through NCOA4-mediated ferritinophagy [0.03%]
环孢素通过NCOA4介导的铁死亡诱导小胶质细胞中铁蛋白吞噬作用的效果
Mustafa Kilic,Ceyhan Hacioglu,Sibel Tuncer et al.
Mustafa Kilic et al.
Cromolyn has anti-inflammatory and neuroprotective effects. However, its influence on microglial cell viability and death pathways remains largely unexplored. This study aimed to elucidate the cellular and molecular mechanisms underlying th...
Coenzyme Q10 attenuates age-associated neurodegeneration via modulation of autophagy and neuroinflammation in aged rats [0.03%]
辅酶Q10通过调节自噬和神经炎症缓解大鼠年龄相关神经退行性变
Parisha Srivastava,Avnish Kumar Verma,Arun Kumar Yadawa et al.
Parisha Srivastava et al.
This study investigates the neuroprotective potential of Coenzyme Q10 (CoQ10) in aging rats, with emphasis on its roles in modulating autophagy and reducing inflammaging. Male Wistar rats, both young (4 months) and aged (24 months), were or...
The therapeutic role of ginseng in promoting hippocampal neurogenesis and ameliorating cognitive function following whole brain radiotherapy in rats [0.03%]
人参促进全脑放疗后海马神经发生及改善认知功能的治疗作用
Sevim Sahin,Nihan Bayindir,Busra Ertas et al.
Sevim Sahin et al.
Whole-brain radiotherapy (WBRT) is a prevalent technique for managing multiple intracranial metastases, however, the cognitive damage in long-term survivors due to WBTR is a critical concern that impacts patients' quality of life. Panax gin...
β-Caryophyllene modulates the JAK2/STAT3 signaling pathway to downregulate neutrophil extracellular traps and alleviate cerebral ischemia-reperfusion injury [0.03%]
β-石竹烯通过调节JAK2/STAT3信号通路下调中性粒细胞胞外陷阱并缓解缺血再灌注脑损伤
Zhengze Shen,Zhongliang Xu,Qiusha Liu et al.
Zhengze Shen et al.
MitoQ reducing sevoflurane-induced cognitive dysfunction by modulating mitochondrial dysfunction [0.03%]
调控线粒体功能异常减少异氟醚诱导的认知障碍
Hengjie Su,Zhibin He,Haotian Wu et al.
Hengjie Su et al.
Introduction: Postoperative neurocognitive disorders (POCD) is a common post-surgical complication that severely impacts patients' quality of life, with perioperative anesthesia exposure recognized as a key contributing f...
Exploring the effects of squalene in the PERK/ATF4/eIF2α/CHOP signalling pathway in an in vitro Alzheimer Disease model and in silico approach [0.03%]
角鲨烯对阿尔茨海默病体外模型及在计算机中PERK/ATF4/eIF2α/CHOP信号通路影响的实验研究
Bahar Sarikamis Johnson,Nilüfer Ercin,Rabia Kalkan Cakmak et al.
Bahar Sarikamis Johnson et al.
Recent studies emphasize the pivotal role of endoplasmic reticulum (ER) stress in Alzheimer's disease (AD), highlighting the need for further investigation into this critical link. In response to ER stress, cells increase reactive oxygen sp...
From the hive to the brain: synergistic potential of honeybee products with alzheimer's drugs [0.03%]
从蜂巢到大脑：蜂蜜产品与阿尔茨海默病药物的协同潜力
Hesham R El-Seedi,Suzy Salama,Aya A Shetaia et al.
Hesham R El-Seedi et al.
Alzheimer's disease (AD) is the most common cause of dementia. The disease spreads over the world and has an impact on human health and welfare. The patients suffer from cognitiv disability in addition to economic and social effects. It is ...