Pharmacological inhibition of RE1 silencing transcription factor disrupts SOX2 expression and neurogenesis in human induced pluripotent stem cells derived neuronal models [0.03%]
药理学抑制RE1沉默转录因子会破坏人诱导多能干细胞来源神经元模型中SOX2的表达及神经发生作用
Ajmal Nassar,Sumukha Hegde,Divya Chandran et al.
Ajmal Nassar et al.
The role of RE1-Silencing Transcription Factor (REST) in human neurogenesis remains unexplored. This study aims to investigate the expression patterns and possible targets of REST during the early stages of human neurogenesis. Methods: Huma...
Piracetam attenuates oxidative stress and inflammation-induced neuronal cell death in rats with vascular dementia potentially via the activation of the AMPK/SIRT-1/Nrf-2 signaling pathway [0.03%]
派拉塞特姆通过活化AMPK/SIRT-1/Nrf-2信号通路潜在地减轻氧化应激和炎症诱导的血管性痴呆大鼠神经元细胞死亡
Phakkawat Thangwong,Jirakhamon Sengking,Naparat Promyoo et al.
Phakkawat Thangwong et al.
Chronic cerebral hypoperfusion (CCH) is the second leading cause of dementia and a major contributor to vascular dementia (VaD). Among the mechanisms underlying CCH-induced cognitive decline, programmed cell death plays a pivotal role. Lyti...
Evaluation of the antidepressant potential of Duloxetine, Coffea canephora, and Nigella sativa in a rat depression model [0.03%]
评估苦橙(Duloxetine)、咖啡(Coffea canephora)和黑籽(Nigella sativa)抗抑郁潜力的 rat 抑郁模型研究
Enas S Abdel-Baky,Shadia A Radwan,Faten Mohamed Abdelhamid et al.
Enas S Abdel-Baky et al.
Depression is a complex disorder involving neurotransmitter imbalance, oxidative stress, and inflammation of the brain tissue. Traditional antidepressants like duloxetine (Cymbalta®) can produce side effects. Natural extracts like Coffea c...
Neuroprotective, antioxidant and anti-inflammatory effect of carnitine in patients with Maple syrup urine disease: branched-chain amino acids and branched-chain keto acids levels [0.03%]
肉毒碱对枫糖尿病患者的神经保护、抗氧化及抗炎作用：支链氨基酸和酮酸水平的影响
Júlia Girardi,Jéssica Lamberty Faverzani,Franciele Fátima Lopes et al.
Júlia Girardi et al.
Maple syrup urine disease (MSUD) is a genetic disorder of the metabolism of branched-chain amino acids (BCAAs). We investigate the effects of treatment with dietary restriction and carnitine supplementation in MSUD patients. During treatmen...
Identification of hub genes and pathways associated with sevoflurane-induced synaptic loss in diabetic offspring via comprehensive transcriptome analysis [0.03%]
全面的转录组分析鉴定与地塞米松诱导的糖尿病后代突触丧失相关的中枢基因及途径
Xiaoru Sun,Xinke Guo,Tingmei Wu et al.
Xiaoru Sun et al.
Vulnerable brain models exhibit heightened susceptibility to anesthetic neurotoxicity, with diabetic offspring warranting particular attention, yet the underlying mechanisms remain unclear. This study integrated bioinformatics and experimen...
Effects of fasudil against photothrombotic stroke in genetically modified obese (ob/ob) mice [0.03%]
法舒地尔对遗传性肥胖(ob/ob)小鼠光化学脑卒中的疗效研究
Mohd Salman,Hiba Shahzad,Syamal K Bhattacharya et al.
Mohd Salman et al.
Obesity and diabetes are major risk factors for ischemic stroke, leading to high comorbidity and poor recovery worldwide. Current treatments are not effective in stroke patients with obesity and diabetes because of their diverse modifying p...
Cognitive impairment in chronic kidney disease: mechanisms, clinical manifestations, and management strategies [0.03%]
慢性肾脏病认知功能障碍：发病机制、临床表现及管理策略
Mariagiovanna Cozza,Virginia Boccardi
Mariagiovanna Cozza
Subjects with chronic kidney disease (CKD) are at higher risk for various neurological disorders, including dementia, depression, and sleep disturbances, all of which can influence disease progression and clinical outcomes. Cognitive impair...
The role of arachidonic acid metabolites in major depressive disorder: mechanisms and therapeutic implications [0.03%]
花生四烯酸代谢物在抑郁症中的作用：机制和治疗意义
Yanjie Qin,Jiaxin Li,Fen Chen et al.
Yanjie Qin et al.
Arachidonic acid (AA) is an important omega-6 polyunsaturated fatty acid (PUFA) stored in esterified form within cell membrane phospholipids, and it is widely present in various cell types. The esterified AA on the inner surface of the cell...
Bicyclol improves cognition deficits and inhibits oxidative stress-induced neuronal cell apoptosis in alzheimer's disease via Nrf2/HO-1 pathway [0.03%]
bicyclol通过Nrf2/HO-1途径改善阿尔茨海默病的认知功能障碍和抑制氧化应激诱导的神经元细胞凋亡
Shuyue Li,Ya Gao,Xiangjian Zhang et al.
Shuyue Li et al.
Alzheimer's disease (AD) is identified as the prevalent neurodegenerative condition globally, ultimately resulting in dementia. Currently, the mechanisms that contribute to AD are not well comprehended, and there are few therapeutic alterna...
Six-membered N-heterocyclic alkaloids as ChE inhibitors in alzheimer's disease treatment [0.03%]
六元氮杂环生物碱作为阿尔茨海默症治疗中的胆碱酯酶抑制剂
Parul Yadav,Anchal Dabas,Ram Singh
Parul Yadav
Cholinesterase (ChE) refers to a group of enzymes that play a critical role in the hydrolysis of choline-based esters, particularly acetylcholine, a key neurotransmitter presents in the nervous system. The two types of cholinesterase are ac...