Serum cortisol and AdipoR2 rs12342 were involved in the correlation between stress and serum cholesterol in a gender-specific manner [0.03%]
性别特异性的应力与血脂关系的横断面研究:血清皮质醇和脂肪细胞受体 2 遗传多态性的影响作用
Yi Lin Shen,Qi Wei Guo,Xue Cheng Li et al.
Yi Lin Shen et al.
Chronic psychosocial stress is heterogeneously related to serum cholesterol and glucocorticoids in epidemiologic studies. Moreover, we have found that adiponectin receptor 2 (AdipoR2) signaling pathway plays a role in mediating the effect o...
Elucidating the material basis and therapeutic mechanisms of Shaoma Zhijing granules for tourette syndrome by UPLC/Q-TOF-MS and multiple models [0.03%]
基于UPLC/Q-TOF-MS和多种模型阐述舒墨止荆颗粒治疗抽动症的物质基础及作用机制
Qian Zhao,Xin-Xin Xu,Jin-Na Yang et al.
Qian Zhao et al.
Tourette syndrome (TS), predominantly affecting children and adolescents aged 2-15 years, significantly impairs quality of life and social functioning. Shaoma Zhijing granules (SMZJG), a compound traditional Chinese medicine (TCM), has demo...
"Rewiring brain immunity: targeting microglial metabolism for neuroprotection in neurodegenerative disorders" [0.03%]
重塑大脑免疫功能：靶向小胶质细胞代谢以对抗神经退行性疾病的神经保护作用
Mustafa M Shokr
Mustafa M Shokr
Neuroinflammation, a pervasive hallmark in many neurological and neuropsychiatric diseases, is largely dictated by the functional phenotypic dynamics of microglia, the immune system of the brain. Recent data illustrate that these phenotypic...
Eucommia ulmoides Oliver (Duzhong) extract ameliorates cerebral ischemic stroke in mice by remodeling intestinal microbiota and metabolites [0.03%]
杜仲提取物通过重塑肠道菌群和代谢产物改善小鼠脑缺血stroke
Xin Qi,Mengyuan Deng,Minhong Li et al.
Xin Qi et al.
Cerebral stroke is characterized by high rate of disability and mortality. Emerging evidence indicates a relationship between acute ischemic stroke and alterations in the intestinal microbiota. Herein, the mechanism of Eucommia ulmoides ext...
Hua Feng Dan protective effect on ischemic stroke through AKT and ERK pathway [0.03%]
hua风丹通过AKT和ERK信号通路对缺血性卒中的保护作用研究
Qilin Shu,Xiaofeng Yuan,Yayang Gao et al.
Qilin Shu et al.
Hua Feng Dan (HFD) has demonstrated definitive efficacy in the treatment of ischemic stroke (IS); however, its active components and underlying mechanisms of action remain unclear. This study employed a rat model of middle cerebral artery o...
Lactobacillus fermentum ATCC 9338 ameliorates immune dysregulation via indoleamine 2, 3-dioxygenase through modulating gut microbial diversity of chronic unpredictable mild stressed mouse [0.03%]
肠菌乳杆菌ATCC 9338通过调节慢性轻度不可预见应激小鼠肠道微生物多样性激活吲哚胺2，3-双加氧酶缓解免疫失调
Sneha Tiwari,Vijay Paramanik
Sneha Tiwari
Gut microbiota (GM) plays a significant role in the pathophysiology of neuropsychiatric diseases like depression. A complex two-way system between gut and brain termed as gut-brain axis (GBA) dependent on intestinal GM and central nervous s...
Modified Xiaoyao San ameliorates LPS-induced depression-like behavior by inhibiting NLRP3-mediated microglial pyroptosis [0.03%]
Modified Xiaoyao San通过抑制NLRP3介导的微胶质细胞pyroptosis改善LPS诱导的类似抑郁的行为
Lei Tian,Pan Su,Gang Feng et al.
Lei Tian et al.
Modified Xiaoyao San (MXYS) is a well-established clinical prescription for the treatment of depression in China. While MXYS shows considerable promise for the development of new antidepressants, its pharmacological mechanisms remain poorly...
The role of metabolomics in stroke: biomarkers of diagnosis and therapy [0.03%]
代谢组学在脑卒中中的作用：诊断和治疗的生物标志物
Youyu Wang,Qi Tian,Mingchang Li
Youyu Wang
Stroke is a neurological condition caused by an acute focal injury to the central nervous system, typically resulting from vascular events such as cerebral infarction, intracerebral hemorrhage, or subarachnoid hemorrhage. It is associated w...
Nrf2-ARE signaling pathway-mediated protection in rat models of intracerebral hemorrhage with different volumes [0.03%]
不同血肿量脑出血大鼠模型中Nrf2-ARE信号通路的保护效应研究
Yipin Liu,Wenyuan Zhang,Qianhong Qing et al.
Yipin Liu et al.
Intracerebral hemorrhage (ICH) is a severe subtype of stroke associated with high mortality and disability. With the global population aging, the incidence of ICH is increasing, highlighting the importance of understanding endogenous protec...
Oxytocin-mediated neuroprotection in ischemic stroke: molecular mechanisms, therapeutic potential and clinical translational prospects [0.03%]
催产素介导的缺血性脑卒中神经保护作用：分子机制、治疗潜力及临床转化前景
Yuan Chen,Tao Li,Long Zou et al.
Yuan Chen et al.
Ischemic stroke (IS), also known as ischemic cerebrovascular accident, is a serious consequence of cerebral ischemia characterized by high morbidity, disability, and mortality. The primary causes of IS include atherosclerosis, cardiogenic e...