Anticonvulsant activity of methanolic extract of Withania cogulans in mice [0.03%]
Withania cogulans甲醇提取物在小鼠中的抗惊厥活性
Zenat Fatima Khattak,Bushra Ansari,Muhammad Jamal et al.
Zenat Fatima Khattak et al.
Mental and neurological diseases including depression, Parkinson's disease, dementia, epilepsy, anxiety disorders and bipolar disorders account for a considerable amount of the world's disease burden. Unfortunately, drugs used in the treatm...
Cognitive impairment caused by hypoxia: from clinical evidences to molecular mechanisms [0.03%]
缺氧引起认知障碍的临床证据及分子机制研究
Xiaoyin Wang,Lili Cui,Xunming Ji
Xiaoyin Wang
Hypoxia is a state of reduced oxygen supply and excessive oxygen consumption. According to the duration of hypoxic period, it can be classified as acute and chronic hypoxia. Both acute and chronic hypoxia could induce abundant neurological ...
The effect of URB597, exercise or their combination on the performance of 6-OHDA mouse model of Parkinson disease in the elevated plus maze, tail suspension test and step-down task [0.03%]
URB597，运动或它们的组合对6-OHDA帕金森病小鼠模型在高架迷宫，尾悬测试和步骤下降任务中表现的影响
Mohaddeseh Ebrahimi-Ghiri,Faezeh Shahini,Mohammad-Reza Zarrindast
Mohaddeseh Ebrahimi-Ghiri
Parkinson disease (PD) is a progressive neurodegenerative disorder that is often accompanied by motor and psychiatric symptoms. Various approaches have been proposed for the treatment of PD. Here, we investigated the effect of a low dose of...
Behavioral, neuroplasticity and metabolic effects of 7,8-dihydroxy-4-methylcoumarin associated with physical activity in mice [0.03%]
7,8-二羟基-4-甲基香豆素与小鼠运动相结合的行为，神经可塑性和代谢作用
Priscilla Karla Fernandes Lopes,Daiane Fátima Engel,Natalia Oliveira Bertolini et al.
Priscilla Karla Fernandes Lopes et al.
The search for strategies to develop resilience against metabolic and neuropsychiatric disorders has motivated the clinical and experimental assessment of early life interventions such as lifestyle-based and use of unconventional pharmacolo...
Correction to: Toxicity of ayahuasca after 28 days daily exposure and effects on monoamines and brain-derived neurotrophic factor (BDNF) in brain of Wistar rats [0.03%]
校正：每天接触28天的ayahuasca的毒性以及对大鼠脑中单胺和脑源性神经营养因子(BDNF)的影响
Camila Schoueri Colaço,Stefany Sousa Alves,Luciana Marangni Nolli et al.
Camila Schoueri Colaço et al.
Published Erratum
Metabolic brain disease. 2021 Dec;36(8):2603-2604. DOI:10.1007/s11011-021-00854-w 2021
Dominika Sitarska,Anna Tylki-Szymańska,Agnieszka Ługowska
Dominika Sitarska
Niemann-Pick type C (NPC) disease is a genetically determined neurodegenerative metabolic disease. It belongs to the lysosomal storage diseases and its main cause is impaired cholesterol transport in late endosomes or lysosomes. It is an au...
Network activity changes in the pathophysiology of Alzheimer's disease: the role of aging and early entorhinal cortex dysfunction [0.03%]
网络活动在阿尔茨海默病病理生理中的变化：年龄和早期内嗅皮层功能障碍的作用
Sharay E Setti,Miranda N Reed
Sharay E Setti
The greatest risk factor for development of the deadly neurodegenerative disorder known as Alzheimer's disease (AD) is advancing age. Currently unknown is what mediates the impact of advanced age on development of AD. Also unknown is what i...
MiR-361-5p promotes oxygen-glucose deprivation/re-oxygenation induced neuronal injury by negatively regulating SQSTM1 in vitro [0.03%]
MiR-361-5p通过负调控SQSTM1促进体外氧糖剥夺/再氧化引起的神经元损伤
Tao Zeng,Sai Zhang,Yan He et al.
Tao Zeng et al.
It has been reported that microRNAs (miRNAs) play essential roles in cerebral ischemia and reperfusion (I/R) injury. This study aimed to explore the role of miR-361-5p in oxygen-glucose deprivation/re-oxygenation-induced neuronal injury in ...
99mTc-HMPAO SPECT imaging reveals brain hypoperfusion during status epilepticus [0.03%]
99mTc-HMPAO SPECT 成像显示癫痫持续状态中的脑低灌注现象
Pablo Bascuñana,Bettina J Wolf,Ina Jahreis et al.
Pablo Bascuñana et al.
Status epilepticus (SE) is a clinical emergency with high mortality. SE can trigger neuronal death or injury and alteration of neuronal networks resulting in long-term cognitive decline or epilepsy. Among the multiple factors contributing t...
Folic acid attenuated learning and memory impairment via inhibition of oxidative damage and acetylcholinesterase activity in hypothyroid rats [0.03%]
叶酸通过抑制氧化损伤和乙酰胆碱酯酶活性来减轻甲状腺功能减退大鼠的学习记忆障碍
Sabiheh Amirahmadi,Mahmoud Hosseini,Somaieh Ahmadabady et al.
Sabiheh Amirahmadi et al.
Hypothyroidism has been reported to be associated with cognitive decline. Considering the role of folic acid (FA) in cognitive performance, the present study was designed to investigate the effects of FA on hypothyroidism-induced cognitive ...