Unlocking NAC's potential ATF4 and m6A dynamics in rescuing cognitive impairments in PTSD [0.03%]
解锁NAC中ATF4和m6A动态变化在创伤后应激障碍认知损伤中的治疗潜力
Yanling Zhou,Xiuhong Yuan,Min Guo
Yanling Zhou
In this study, we investigated the therapeutic potential of N-acetylcysteine (NAC) in a mouse model of post-traumatic stress disorder (PTSD) induced by a single prolonged stress (SPS) protocol. Our findings demonstrate that NAC treatment si...
A novel approach to metabolic profiling in case models of MECP2-related disorders [0.03%]
MECP2相关疾病模型中代谢谱分析的新方法
Jessica A Cooley Coleman,Bridgette A Moffitt,William C Bridges et al.
Jessica A Cooley Coleman et al.
Genetic abnormalities of the MECP2 gene cause several conditions grouped under the umbrella term of MECP2-related disorders and characterized by a variety of phenotypes. We applied a functional approach to identify metabolic profiles in two...
Unraveling the role of Nrf2 in dopaminergic neurons: a review of oxidative stress and mitochondrial dysfunction in Parkinson's disease [0.03%]
Nrf2在多巴胺能神经元中的作用机制：帕金森病氧化应激和线粒体功能障碍研究进展综述
Manpreet Kaur,Khadga Raj Aran
Manpreet Kaur
Nuclear factor erythroid 2-related factor 2 (Nrf2) is an essential transcriptional factor, involved in the regulation of countenance of various anti-oxidant enzymes and cytoprotective genes that respond to mitochondrial dysfunctions, oxidat...
Gut microbiota-derived short chain fatty acids act as mediators of the gut-liver-brain axis [0.03%]
肠道微生物群衍生的短链脂肪酸作为肠-肝-脑轴介体的作用
Cunyin Li,Jingtong Yao,Chang Yang et al.
Cunyin Li et al.
The gut microbiota plays a crucial role in the communication between the gut, liver, and brain through the production of short chain fatty acids (SCFAs). SCFAs serve as key mediators in the Gut-Liver-Brain Axis, influencing various physiolo...
Glutamate/GABA/glutamine ratios in intact and ischemia reperfusion challenged rat brain subregions, the effect of ischemic preconditioning [0.03%]
缺血预处理对完整和缺血再灌注损伤大鼠脑亚区谷氨酸/γ-氨基丁酸/谷氨酰胺比例的影响
Eva Baranovicova,Dagmar Kalenska,Jan Lehotsky
Eva Baranovicova
The proper function of the brain is entirely dependent on intact neurotransmission, where glutamate (Glu) and γ-aminobutyric acid (GABA) are the two most present neurotransmitters. Maintenance of these neurotransmitters pools is strictly r...
Pauline Bozon-Rivière,Marika Rudler,Nicolas Weiss et al.
Pauline Bozon-Rivière et al.
Despite a better understanding in its prognosis and pathogenesis, hepatic encephalopathy (HE) remains one of the major complications of Transjugular Intrahepatic Portosystemic Shunt (TIPS) with a prevalence ranging from 35 to 50%. Its epide...
Altered gut microbiome and serum metabolome profiles associated with essential tremor [0.03%]
与特发性震颤相关的肠道菌群和血清代谢组特征改变
Zhenzhen Yan,Zhilin Zheng,Lanxiao Cao et al.
Zhenzhen Yan et al.
The genetic predisposition and environmental factors both trigger the complex neurological dyskinesia of essential tremor (ET). Gut dysbiosis may facilitate the occurrence and development of neurological diseases. Therefore, it is worth exp...
The effects of ursodeoxycholic acid on Parkinson's disease, a mechanistic review of the recent evidence [0.03%]
熊去氧胆酸对帕金森病的影响：近期证据的机制综述
Seyed Mehrad Razavi,Niusha Esmaealzadeh,Mazyar Ataei et al.
Seyed Mehrad Razavi et al.
Parkinson`s disease stands as the second-most widespread neurodegenerative disorder. Parkinson`s disease is relentless in progression and irreversible in nature, for which there is no cure. Therapies are only used to attenuate motor symptom...
Heba G Abdelhamed,Arwa A Hassan,Alaa A Sakraan et al.
Heba G Abdelhamed et al.
The central nervous system (CNS) is immune-privileged by several immuno-modulators as interleukins (ILs). ILs are cytokines secreted by immune cells for cell-cell signaling communications and affect the functions of the CNS. ILs were report...
2-dodecyl-6-methoxycyclohexa-2,5-diene-1,4-dione protects against MPP+-induced neurotoxicity by ameliorating oxidative stress, apoptosis and autophagy in SH-SY5Y cells [0.03%]
2-癸基-6-甲氧基环己二烯-1，4-二酮通过改善氧化应激、凋亡和自噬来保护SH-SY5Y细胞免受MPP+诱导的神经毒性损伤
Kechen Du,Ying Su,Qiong Song et al.
Kechen Du et al.
2-dodecyl-6-methoxycyclohexa-2,5-diene-1,4-dione (DMDD) is a cyclohexanedione compound extracted from the roots of Averrhoa carambola L. Several studies have documented its beneficial effects on diabetes, Alzheimer's disease, and cancer. Ho...