Ghadah H Alshehri,Hayder M Al-Kuraishy,Huda Jaber Waheed et al.
Ghadah H Alshehri et al.
Tirzepatide (TRZ) is a dual agonist of glucagon-like peptide 1 (GLP-1) and gastric inhibitory polypeptide (GIP) receptors that were recently approved for the treatment of type 2 diabetes (T2D) and obesity. Of note is that T2D and obesity, b...
Immunomodulatory and behavioral effects of ayahuasca and N, N-dimethyltryptamine in a rat model of lipopolysaccharide-induced depression [0.03%]
Ayahuasca和N，N-二甲基色胺对脂多糖诱导的抑郁大鼠模型免疫调节和行为的影响
Daniel do Nascimento Sousa,Monique de Azevedo,Maria Lucília Santos et al.
Daniel do Nascimento Sousa et al.
Ayahuasca (Aya) is an Amazonian beverage traditionally used as medicine by Indigenous people in South America to treat various illnesses and have shown a potential to treat depression. This study aimed to investigate the antidepressant effe...
Unraveling novel mechanisms of ATP-Binding cassette (ABC) transporter in insulin Resistance-induced amyloidogenesis [0.03%]
解开ATP结合盒转运蛋白（ABC）在胰岛素抵抗诱导的淀粉样变性中的新机制
Akhil Sharma,Ashi Mannan,Thakur Gurjeet Singh
Akhil Sharma
Insulin resistance (IR) impairs glucose uptake and metabolism, whereas amyloidogenesis, the formation of abnormal protein aggregation, forming insoluble fibrils called amyloids, which are linked with numerous neurodegenerative diseases (NDD...
Targeting NOX inhibitors in neurodegeneration: a therapeutic perspective [0.03%]
针对神经退行性疾病的NOX抑制剂疗法展望
Sifat Kaur,Reet Verma,Veerta Sharma et al.
Sifat Kaur et al.
Neurodegenerative diseases are characterized by progressive neuronal loss, cognitive decline, and motor dysfunction driven by oxidative stress and neuroinflammation. NADPH oxidases (NOX) are a major source of reactive oxygen species (ROS) i...
The effect of N-acetylcysteine on apoptosis and NGF-Akt/Bad pathway in the hippocampus tissue of cerebral ischemia-reperfusion in male rats [0.03%]
N-乙酰半胱氨酸对雄性脑缺血再灌注海马组织中NGF-Akt/Bad通路及细胞凋亡的影响研究
Hamed Saniei,Roya Naderi
Hamed Saniei
Apoptosis is the primary pathological feature of neuronal injury caused by cerebral ischemia-reperfusion (I/R). The detailed molecular mediators are still being debated. This study aims to examine the effects of cerebral ischemia-reperfusio...
Brain morphological changes in type 2 diabetes patients with painful peripheral neuropathy [0.03%]
2型糖尿病伴发疼痛性周围神经病变患者的脑结构改变
Miao He,Jiaying Yang,Xueqing Liu et al.
Miao He et al.
We investigates changes in brain volume and cortical thickness in patients with type 2 diabetes mellitus (T2DM) and peripheral neuropathy (DPN), particularly those with neuropathic pain. 105 participants were divided into three groups: T2DM...
Quinoa extract restored behavioral damage and neurotoxicity induced by a Parkinson's disease-like model in Drosophila melanogaster [0.03%]
藜麦提取物可修复果蝇帕金森模型的行为损伤及神经毒性
Magna Sotelo Barrientos,Marcia Rósula Poetini,Eliana Jardim Fernandes et al.
Magna Sotelo Barrientos et al.
Gut microbiota and serum metabolomics unveil the role of Phellinus ribis polysaccharides in improving Alzheimer's disease symptoms in senescence-accelerated mice [0.03%]
肠菌和血清代谢组揭示松乳菇多糖改善SAM小鼠阿尔兹海默症症状的作用机制
Zhiyuan Zhang,Shuai Wang,Rong Rong et al.
Zhiyuan Zhang et al.
Alzheimer's disease (AD), a complex neurodegenerative disorder with limited therapeutic options, urgently requires innovative strategies targeting its underlying mechanisms. Phellinus ribis polysaccharides (PRG), a bioactive compound with p...
Unlocking the neuroprotective potential of peptide nucleic acids 5 (PNA5) in neurological diseases: molecular mechanisms to therapeutic approaches [0.03%]
肽核酸5(PNA5)在神经疾病中的神经保护作用：分子机制与治疗策略
Pratyush Porel,Garry Hunjan,Navpreet Kaur et al.
Pratyush Porel et al.
Peptide nucleic acids (PNAs) are synthetic nucleic acid analogues offering distinct structural and functional advantages over conventional RNA and DNA, positioning them as powerful molecules in molecular biology. Recently, PNAs have gained ...
Targeting Acyl-CoA synthetase long-chain family member 4: a potential approach for the treatment of cerebral ischemia/reperfusion injury [0.03%]
靶向长链脂肪酸辅酶A合成酶家族成员4：治疗脑缺血再灌注损伤的潜在方法
Nikita Patil,Lokesh Kumar Bhatt
Nikita Patil
Cerebral ischemia/reperfusion injury causes high rates of morbidity and death. Recent studies have shown that ferroptosis, a type of controlled cell death brought on by lipid peroxidation, worsens cerebral ischemia/reperfusion injury. Acyl-...