Various repair events following CRISPR/Cas9-based mutational correction of an infertility-related mutation in mouse embryos [0.03%]
基于CRISPR/Cas9的基因修正技术在小鼠胚胎中的应用及修正后的修复事件
B Bekaert,A Boel,A Rybouchkin et al.
B Bekaert et al.
Purpose: Unpredictable genetic modifications and chromosomal aberrations following CRISPR/Cas9 administration hamper the efficacy of germline editing. Repair events triggered by double-strand DNA breaks (DSBs) besides non...
The impact of a second embryo biopsy for preimplantation genetic testing for monogenic diseases (PGT-M) with inconclusive results on pregnancy potential: results from a matched case-control study [0.03%]
第二次胚胎活检对单基因病植入前遗传学检测(PGT-M)意义不明确结果的妊娠潜能影响：病例对照研究匹配结果显示
Cristina Guarneri,Marco Reschini,Monica Pinna et al.
Cristina Guarneri et al.
Purpose: To evaluate whether a second biopsy, following a first diagnostic failure on blastocysts tested for preimplantation genetic testing for monogenic diseases (PGT-M), allows to obtain genetic diagnosis and to what e...
Endocrine-disrupting chemical concentrations in follicular fluid and follicular reproductive hormone levels [0.03%]
卵泡液中内分泌干扰化学物质浓度与卵泡生殖激素水平的关系研究
Nathalie Hoffmann-Dishon,Zohar Barnett-Itzhaki,Daniel Zalko et al.
Nathalie Hoffmann-Dishon et al.
Purpose: To determine correlations between chemicals in follicular fluid (FF) and follicular reproductive hormone levels. Methods: The ...
Exosomal encapsulation of miR-3198 promotes proliferation and migration of trophoblasts in preeclampsia [0.03%]
外泌体介导的miR-3198包裹促进子痫前期滋养细胞增殖和迁移的作用及机制研究
Yuchen Li,Yanling Yu,Dejun Li et al.
Yuchen Li et al.
Purpose: Preeclampsia (PE) is a vascular remodeling disorder cloesly linked to trophoblast dysfunction, involving defects in their proliferation, migration, and apoptosis. Maternal exosomal microRNAs (miRNAs) have been re...
Pathologic maternal and neonatal outcomes associated with programmed embryo transfer: potential etiologies and strategies for prevention [0.03%]
与胚胎移植相关的母体和新生儿病理结果及潜在病因和预防策略分析
Kirk P Conrad,Frauke von Versen-Höynck,Valerie L Baker
Kirk P Conrad
Purpose: In the first of two companion papers, we comprehensively reviewed the recent evidence in the primary literature, which addressed the increased prevalence of hypertensive disorders of pregnancy, late-onset or term...
Identification novel mutations and phenotypic spectrum expanding in PATL2 in infertile women with IVF/ICSI failure [0.03%]
PATL2基因新突变的鉴定及其不孕女性试管婴儿/卵胞浆内单精子显微注射失败的表型谱系扩展
Zhiqi Ye,Da Li,Xiangli Niu et al.
Zhiqi Ye et al.
Aim: Abnormalities in oocyte maturation, fertilization, and early embryonic development are major causes of primary infertility in women who are undergoing IVF/ICSI attempts. Although many genetic factors responsible for ...
Pathologic maternal and neonatal outcomes associated with programmed embryo transfer [0.03%]
程序化胚胎移植相关的母胎不良结局事件分析
Kirk P Conrad,Frauke von Versen-Höynck,Valerie L Baker
Kirk P Conrad
Purpose: In this first of two companion papers, we critically review the evidence recently published in the primary literature, which addresses adverse maternal and neonatal pregnancy outcomes associated with programmed e...
Expression of long non-coding RNA GAS5 by first trimester screening predicts the occurrence of gestational hypertension and pre-eclampsia [0.03%]
孕早期长链非编码RNA GAS5的表达预测妊娠期高血压和子痫前期的发生
Li Wang,Jinfeng Chen,Huihui Li et al.
Li Wang et al.
Aims: Hypertensive disorders of pregnancy (HDP) is a unique disease during gestational period, which is detrimental to pregnancy outcome. This study examined the clinical significance of long non-coding RNA GAS5 in gestat...
Mechanisms of YAP1-mediated trophoblast ferroptosis in recurrent pregnancy loss [0.03%]
YAP1介导的胎盘滋养细胞铁死亡在复发性流产中的机制研究
Liping Chen,Fangfang Dai,Yanjie Huang et al.
Liping Chen et al.
Purpose: The purpose of our study is to investigate the function of YAP1 in the trophoblast ferroptosis and maternal-fetal interface communication of RPL. ...
Parenthood desire, perceived parenthood stigma, and barriers to achieving parenthood in childless sexual minority men [0.03%]
无子女性少数男性群体的求子意愿、隐性求子障碍及其影响因素研究
Samantha Yee,Amar A Mamone,Maryam Fatima et al.
Samantha Yee et al.
Purpose: To examine the parenthood desire, perceived parenthood stigma, and barriers to achieving parenthood among sexual minority men (SMM) in Canada, and to investigate factors influencing their fertility and assisted r...