The spermatozoon neck role in infertility and intracytoplasmic sperm injection outcomes [0.03%]
精子颈段与男性不育和卵胞浆内精子注射结局的关系
Derek F Kluczynski,Isabel Nester,Haley Prine et al.
Derek F Kluczynski et al.
The mammalian spermatozoon neck is a unique structure that functions during spermatid differentiation and spermatozoa swimming, and its contents are critical for post-fertilization embryogenesis. Mutations in proteins localizing to the neck...
An artificial intelligence platform for automated measurement and count estimation of ovarian follicles during ovarian stimulation and IVF: a multicenter study [0.03%]
一种人工智能平台在卵巢刺激和体外受精期间自动化测量和估计卵巢卵泡数量的多中心研究
Piotr Wygocki,Andrzej Zapała,Mateusz Ulfig et al.
Piotr Wygocki et al.
Purpose: Ultrasound measurement of follicle diameter is essential in IVF monitoring. This study evaluates the analytical performance of follicle counts and size measurements from two-dimensional images using an AI-based p...
Harsh Sheth,Pritti Priya,Vineet Mishra et al.
Harsh Sheth et al.
Purpose: To systematically investigate the genetic architecture of severe male infertility in Indian men, with a specific focus on chromosomal abnormalities and the contribution of de novo variants. ...
Predictors of referral for fertility preservation counseling in patients diagnosed with cancer [0.03%]
癌症患者生育力保存咨询转诊的预测因素
Paris N Chey,Miranda L M Delwalla,Julia Shuford et al.
Paris N Chey et al.
Objective: Fertility preservation (FP) is an important aspect of care for reproductive-aged cancer patients since treatment can significantly impact fertility. Despite professional recommendations for early referral to FP...
Functional interplay between endoplasmic reticulum stress and mitochondrial activity in a post-ovulatory aging model of mouse oocytes [0.03%]
卵巢排卵后老化小鼠卵母细胞模型中内质网应激与线粒体活性的相互作用
Fumihiro Nakamura,Isao Takehara,Saki Hine et al.
Fumihiro Nakamura et al.
Purpose: To investigate whether targeting the ER-mitochondria axis can improve embryonic development in a post-ovulatory aging (POA) model by evaluating organelle-specific modulation. ...
Exploring the increasing aneuploidy stress effects on embryo morphokinetic development: non-linear and stage-specific disruption in developmental timing [0.03%]
探讨染色体非整倍体增多对胚胎形态动力学发育影响：发展的时效性受到非线性和阶段特异性干扰
Iulian C Roman,Graham Coull,Adriana Michielsen et al.
Iulian C Roman et al.
Purpose: To investigate how different forms of chromosomal imbalance affect human embryo morphokinetics, using a dataset of PGT-A tested embryos and a robust statistical framework that accounts for patient- and cycle-leve...
Fertility preservation in women with diminished ovarian reserve: evaluating the AMH criteria [0.03%]
卵巢储备功能减退女性的生育力保存：基于AMH标准的评估
Maria Elisabetta Coccia,Benedetta Gabbrielli,Giulia Cutajar et al.
Maria Elisabetta Coccia et al.
Purpose: Does fertility preservation (FP) through oocyte cryopreservation provide realistic reproductive opportunities for diminished ovarian reserve (DOR)? Literature suggests cumulative live birth rates of 30-45% with 8...
The prevalence of pathogenic variants in medically actionable genes among individuals with idiopathic hypogonadotropic hypogonadism/Kallmann syndrome [0.03%]
青春期发育异常患者中致病基因变异的分布及其临床意义
Jaclyn M Kwal,Lynn P Chorich,Anna Navitski et al.
Jaclyn M Kwal et al.
Purpose: Idiopathic hypogonadotropic hypogonadism (IHH) and Kallmann syndrome (KS) are rare reproductive disorders with known genetic heterogeneity. Using exome sequencing, our group previously reported the prevalence of ...
Clinical utility of post-GnRH agonist trigger serum hormonal testing and effect on the incidence of empty follicle syndrome: a single-center retrospective cohort study [0.03%]
GnRH激动剂扳机后的血清激素检测的临床应用价值及其对空卵泡综合征发病率的影响：单中心回顾性队列研究
Robert Kloosterman,Trish Dinh,Jennia Michaeli
Robert Kloosterman
Purpose: The purpose of this study is to assess whether discontinuing routine serum hormone testing following gonadotropin-releasing hormone (GnRH) agonist trigger affects the incidence of empty follicle syndrome (EFS) an...
Single-Molecule approach to quantify sperm single-stranded DNA damage using the novel sperm repair-assisted damage detection (SRADD) assay [0.03%]
新型精子修复辅助损伤检测试剂盒(SRADD)用于精子单链DNA损伤的单分子检测及定量分析方法学研究
Elina Djalovski,Oren Kashi,Micha Baum et al.
Elina Djalovski et al.
Purpose: Sperm DNA damage is linked to male infertility and poor reproductive outcome. Single-stranded DNA (ssDNA) damage in sperm is the most common type of damage yet is not specifically targeted by the commonly used DN...