Infertile females with biallelic mutations in APC/C genes are characterized by oocyte or early embryo defects [0.03%]
APC/C基因双等位基因突变的不孕女性以卵母细胞或早期胚胎缺陷为特征
Ying Cui,Shuai Zhao,Changlong Zhang et al.
Ying Cui et al.
Purpose: The objective of this study was to elucidate the role of anaphase promoting complex/cyclosome (APC/C)-related genes in cases of female infertility characterized by disturbances in oocyte maturation, failure of fe...
Diverse developmental velocities of blastocyst development emerge as early as a few hours after insemination: morphokinetic analysis of fertilisation in days 4-7 blastocysts [0.03%]
多样的囊胚发育速度在受精后几小时即已出现:第4-7天囊胚受精过程中形态动力学分析
Nanoha Fujiwara,Kenji Ezoe,Giovanni Coticchio et al.
Nanoha Fujiwara et al.
Purpose: The time at which embryo developmental velocity variations occur remains unknown. Therefore, we analysed the morphokinetic trajectory of human early fertilisation from the extrusion of the second polar body (PB2)...
Examining the fate of frozen embryo inventory: an analysis of patients' embryo disposition decisions [0.03%]
审视冷冻胚胎库存的命运:分析患者的胚胎处置决定
Paxton Voigt,Emily Michelle Weidenbaum,Amanda Atkinson et al.
Paxton Voigt et al.
Purpose: To determine factors associated with embryo disposition decisions at a large academic fertility center. Methods: We performed ...
Research on the perception of pre-semen collection stress and its influencing factors in men on the day of oocyte retrieval in IVF-ET [0.03%]
体外受精促排卵取卵日男性术前收集精液感知状况及其影响因素的研究
Yuan Jiang,Fengyi Mo,Shuying Wang et al.
Yuan Jiang et al.
Purpose: This study aimed to investigate the status and influencing factors of perceived stress in men before sperm collection on the day of oocyte retrieval during IVF-ET, thereby providing a theoretical basis for nursin...
Whole-genome and whole-exome sequencing of Mayer-Rokitansky-Küster-Hauser syndrome-discordant monozygotic twins [0.03%]
梅耶-罗特坦斯基-库斯特-豪泽综合征不一致的同卵双胞胎的全基因组和全外显子测序
Wenqing Ma,Fangfang Fu,Wenwen Wang et al.
Wenqing Ma et al.
Purpose: Mayer-Rokitansky-Küster-Hauser syndrome (MRKHS), characterized by congenital uterine and vaginal aplasia, lacks definitive etiology. Discordant monozygotic (MZ) twins provide a unique model to dissect postzygoti...
AMH decline during chemotherapy reflects breast cancer cell DNA damage response (DDR) proficiency: the ONCO AMH1 pilot study [0.03%]
化疗期间AMH下降反映了乳腺癌细胞DNA损伤反应能力:ONCO AMH1试点研究
Christine Decanter,Audrey Dassonneville,Emmanuelle DOrazio et al.
Christine Decanter et al.
Purpose: The impact of a germline BRCA1/2 pathogenic variant (gBRCApv) on baseline or late post-treatment AMH concentrations in breast cancer patients has been extensively studied, yielding mixed conclusions. However, whe...
Raoul Orvieto
Raoul Orvieto
Influence of parental age on chromosomal abnormalities in PGT-A embryos: exponentially increasing in the mother and completely null in the father [0.03%]
高龄父母胚胎染色体异常在植入前遗传学检测中的影响:母亲呈指数增加而父亲无影响
Roberto Matorras,Silvia Sierra,Silvia Pérez-Fernández et al.
Roberto Matorras et al.
Purpose: To study the influence of parental age on aneuploidy rates (AR) in PGT-A cycles and on the recurrence rate. Methods: A total o...
Anti-Mullerian hormone (AMH) protects ovarian follicle loss by downregulating granulosa cell function in in vitro and in vivo models [0.03%]
抗苗勒管激素通过下调体外和体内模型中小鼠颗粒细胞功能来保护卵泡丢失的作用及机制研究
Laura Detti,Michael C Mari,Michael P Diamond et al.
Laura Detti et al.
Purpose: AMH inhibits hormone production in luteinized granulosa cells (GCs) and stalls ovarian follicle development in vitro and in vivo. We sought to confirm AMH's mechanism of action through SMAD activation and investi...