The analysis of cancer screening trials in which the outcome is the incidence of late-stage disease [0.03%]
晚期疾病发生率为结果的癌症筛查试验分析
Noel S Weiss,Larry Kessler,Ruth Etzioni
Noel S Weiss
The National Health Service-Galleri randomized trial seeks to determine the extent to which a blood-based multi-cancer screening test can lead to a reduced incidence of a variety of cancers that are at a late stage as of the time of initial...
The decade of double-trouble: live birth and stillbirth sex ratio variation in Finland during the COVID-19 pandemic and Russia's attack on Ukraine [0.03%]
双重重击的十年：COVID-19大流行和俄罗斯入侵乌克兰期间芬兰的活产和死胎性别比变化
Samuli Helle,Antti O Tanskanen,Mirkka Danielsbacka
Samuli Helle
Exogenous shocks experienced by the population like armed conflicts, natural disasters and economic downturns have all been suggested to correlate with variation in human sex ratio at birth, either through sex-specific embryonic mortality a...
Risk prediction for individual patients and the pitfalls of selecting an optimal prediction model: do not judge a model by its c-statistic [0.03%]
预测个体患者风险和选择最佳预测模型的陷阱——不要单纯以C指数来评价模型优劣
Jan Willem van Dalen
Jan Willem van Dalen
Researchers often report the area under the curve (AUC/c-statistic), Brier-index (BI), and explained variation (R2) to assess risk prediction model performance. This may be inappropriate for scores to estimate individual patient risks becau...
Adiposity measures, body composition, and all-cause and cause-specific mortality in the Korean national health screening cohort: beyond body mass index [0.03%]
基于韩国国家健康筛查队列的肥胖指标、机体成分与全因及特定原因死亡率：超越体质指数
Jin Eui Kim,Dong Hoon Lee,Edward Giovannucci et al.
Jin Eui Kim et al.
While body mass index (BMI) is the most widely-used measure of adiposity, alternative measures, including waist circumference (WC), waist-to-height ratio (WHtR), weight-adjusted waist index (WWI), and a body shape index (ABSI), have been pr...
Combining external placebo-arm data in a prevention trial: effects of cocoa extract supplementation on cardiovascular disease [0.03%]
结合外部安慰剂组数据在预防性试验中的应用——可可提取物对心血管疾病的疗效研究
Rikuta Hamaya,Sidong Li,Pamela M Rist et al.
Rikuta Hamaya et al.
Validation of self-reported family history of myocardial infarction using nationwide health care data [0.03%]
利用全国医疗卫生数据验证自我报告的家庭成员患心肌梗死史的真实性
Agnes Wahrenberg,Karin Leander,Henrike Häbel et al.
Agnes Wahrenberg et al.
Long-term negative divergence in mortality at ages 25-49 years between the United Kingdom and 21 peer countries between 1990 and 2019 [0.03%]
1990年至2019年英国与21个同行国家在25-49岁年龄组间的死亡率长期负向分歧
David A Leon,Dmitry Jdanov,Naomi Medina-Jaudes et al.
David A Leon et al.
Background: The poor performance of the UK in reducing mortality compared to many other high-income countries following the 2008 financial crisis have been extensively studied, with particular attention to deaths of despa...
Prevalence, characteristics, and projection of long-term childhood cancer survivors in Sweden [0.03%]
瑞典长期儿童癌症幸存者患病率、特征及预测分布
Elena Extrand,Emerald G Heiland,Genevieve Allen et al.
Elena Extrand et al.
Population-level descriptions of long-term childhood cancer survivors are fundamental to survivorship care and research but seldom available. Accordingly, we aimed to describe long-term childhood cancer survivors at the population-level and...
Johannes Hruza,Arvid Sjölander,Erin E Gabriel et al.
Johannes Hruza et al.
Dynamic treatment regimes have been proposed to personalize treatment decisions by utilizing historical patient data, but they may not always improve on the current standard of care. It is thus meaningful to integrate the standard of care i...
Forecast of dementia prevalence in Germany and subnational regions until 2060 using microsimulation [0.03%]
基于微模拟的德国及各联邦州地区痴呆患病率预测至2060年
Katrin Schüssel,Gabriela Brückner,Helmut Schröder et al.
Katrin Schüssel et al.
The number of dementia cases is expected to rise in ageing societies with concomitant requirements for healthcare planning. While national figures for countries are widely available, subnational regional heterogeneity is rarely considered. ...