Circulating insulin-like growth factor-I and risk of 25 common conditions: outcome-wide analyses in the UK Biobank study [0.03%]
循环的类胰岛素生长因子-I与25种常见疾病的风险的关系：英国生物银行研究的广泛结果分析
Keren Papier,Anika Knuppel,Aurora Perez-Cornago et al.
Keren Papier et al.
While there is strong epidemiological evidence that circulating insulin-like growth factor-I (IGF-I) is associated with a higher risk of several cancers, little is known about its association with non-cancer outcomes. We investigated associ...
Allen J Wilcox,Marianna Cortese,D Robert McConnaughey et al.
Allen J Wilcox et al.
SGA (small for gestational age) is widely used to identify high-risk infants, although with inconsistent definitions. Cut points range from 2.5th to 10th percentile of birthweight-for-gestational age. We used receiver operator characteristi...
A robust mean and variance test with application to high-dimensional phenotypes [0.03%]
稳健的均值和方差检验及在高维性状中的应用
James R Staley,Frank Windmeijer,Matthew Suderman et al.
James R Staley et al.
Most studies of continuous health-related outcomes examine differences in mean levels (location) of the outcome by exposure. However, identifying effects on the variability (scale) of an outcome, and combining tests of mean and variability ...
Turtles all the way down: do biological mechanisms for epidemiological observations always matter? [0.03%]
一切尽在龟中：对流行病学观察具有生物机制总是重要吗？
David T P Buis,Jos van Roosmalen
David T P Buis
Increases in COVID-19 are unrelated to levels of vaccination across 68 countries and 2947 counties in the United States [0.03%]
68个国家和美国2947个县的COVID-19增加与疫苗接种水平无关
S V Subramanian,Akhil Kumar
S V Subramanian
Association between vitamin K1 intake and mortality in the Danish Diet, Cancer, and Health cohort [0.03%]
丹麦饮食、癌症和健康队列中维生素K1摄入与死亡率的关联性研究
Claire R Palmer,Jamie W Bellinge,Frederik Dalgaard et al.
Claire R Palmer et al.
Reported associations between vitamin K1 and both all-cause and cause-specific mortality are conflicting. The 56,048 participants from the Danish Diet, Cancer, and Health prospective cohort study, with a median [IQR] age of 56 [52-60] years...
Non-therapeutic male circumcision in infancy or childhood and risk of human immunodeficiency virus and other sexually transmitted infections: national cohort study in Denmark [0.03%]
非治疗性婴儿或儿童期男性包皮环切术与人类免疫缺陷病毒和其他性病感染风险：丹麦的全国队列研究
Morten Frisch,Jacob Simonsen
Morten Frisch
Whether male circumcision in infancy or childhood provides protection against the acquisition of human immunodeficiency virus (HIV) or other sexually transmitted infections (STIs) in adulthood remains to be established. In the first nationa...
Strength in causality: discerning causal mechanisms in the sufficient cause model [0.03%]
因果关系中的力量：在充分原因模型中辨别因果机制
Etsuji Suzuki,Eiji Yamamoto
Etsuji Suzuki
The assessment of causality is fundamental to epidemiology and biomedical sciences. One well-known approach to distinguishing causal from noncausal explanations is the nine Bradford Hill viewpoints. A recent article in this journal revisite...
Time trends of chronic immune diseases by year of birth in Danish registries [0.03%]
丹麦登记系统中按出生年份划分的慢性免疫疾病的时间变化趋势
Astrid Sevelsted,Bo Chawes,Jakob Stokholm et al.
Astrid Sevelsted et al.
Chronic immune diseases are often reported to be on the rise and are speculated to share early life risk factors. Here, we investigated year of birth as a common denominator for time trends using the consistent data source of the Danish Nat...
Bone mineral density and risk of cardiovascular disease in men and women: the HUNT study [0.03%]
骨矿物质密度与心血管疾病的关系：HUNT研究中的男性和女性对象
Laxmi Bhatta,Aivaras Cepelis,Sigrid A Vikjord et al.
Laxmi Bhatta et al.
The association between bone mineral density (BMD) and cardiovascular disease (CVD) is not fully understood. We evaluated BMD as a risk factor for cardiovascular disease and specifically atrial fibrillation (AF), acute myocardial infarction...