Nuts and legumes consumption and risk of colorectal cancer: a systematic review and meta-analysis [0.03%]
坚果和豆类的摄入与结直肠癌风险的关系：系统评价和.meta.分析
Shaoyue Jin,Youjin Je
Shaoyue Jin
Several case-control and prospective cohort studies have examined the association between the consumption of nuts and legumes and the risk of colorectal cancer. For the quantitative assessment of this association, we conducted a meta-analys...
Exploring and mitigating potential bias when genetic instrumental variables are associated with multiple non-exposure traits in Mendelian randomization [0.03%]
探索并缓解门德尔随机化中基因Instrumental Variable与多个非暴露特征相关时的潜在偏差
Qian Yang,Eleanor Sanderson,Kate Tilling et al.
Qian Yang et al.
With the increasing size and number of genome-wide association studies, individual single nucleotide polymorphisms are increasingly found to associate with multiple traits. Many different mechanisms could result in proposed genetic IVs for ...
Rafael Hermelink,Michael F Leitzmann,Georgios Markozannes et al.
Rafael Hermelink et al.
Several systematic reviews and meta-analyses have summarized the association between sedentary behavior (SB) and cancer. However, the level of evidence and the potential for risk of bias remains unclear. This umbrella review summarized the ...
Epigenetic mechanisms of lung carcinogenesis involve differentially methylated CpG sites beyond those associated with smoking [0.03%]
表观遗传机制介导的肺部致癌作用涉及吸烟相关CpG岛以外的差异甲基化位点
Dusan Petrovic,Barbara Bodinier,Sonia Dagnino et al.
Dusan Petrovic et al.
Smoking-related epigenetic changes have been linked to lung cancer, but the contribution of epigenetic alterations unrelated to smoking remains unclear. We sought for a sparse set of CpG sites predicting lung cancer and explored the role of...
Vitamin D food fortification in European countries: the underused potential to prevent cancer deaths [0.03%]
欧洲国家的维生素D强化食品：预防癌症死亡的潜在作用被低估了
Tobias Niedermaier,Thomas Gredner,Sabine Kuznia et al.
Tobias Niedermaier et al.
Background: Meta-analyses of randomized controlled trials have shown that vitamin D supplementation reduces cancer mortality by 13%. Vitamin D fortification of foods may increase vitamin D levels in a similar manner as vi...
Lifestyle and metabolic factors for nonalcoholic fatty liver disease: Mendelian randomization study [0.03%]
非酒精性脂肪肝的发病因素：孟德尔随机化研究
Shuai Yuan,Jie Chen,Xue Li et al.
Shuai Yuan et al.
The risk factors for nonalcoholic fatty liver disease (NAFLD) have not been clearly identified. We conducted a Mendelian randomization (MR) study to explore this. Independent genetic variants strongly associated with 5 lifestyle and 9 metab...
A twenty-first century perspective on concepts of modern epidemiology in Ignaz Philipp Semmelweis' work on puerperal sepsis [0.03%]
伊格纳兹·菲利普斯·塞梅尔维斯关于产褥热工作的现代流行病学概念的21世纪视角
Andreas Stang,Fabian Standl,Charles Poole
Andreas Stang
We aimed to review Semmelweis's complete work on puerperal sepsis mortality in maternity wards in relation to exposure to cadavers and chlorine handwashing and other factors from the perspective of modern epidemiological methods. We reviewe...
Fetal exposure to maternal cigarette smoking and male reproductive function in young adulthood [0.03%]
母体吸烟暴露与子代年轻期的男性生殖功能之间的关系
Katia Keglberg Hærvig,Kajsa Ugelvig Petersen,Aleksander Giwercman et al.
Katia Keglberg Hærvig et al.
Maternal smoking during pregnancy constitutes a potential, major risk factor for adult male reproductive function. In the hitherto largest longitudinal cohort, we examined biomarkers of reproductive function according to maternal smoking du...
APOE ε4 and late-life cognition: mediation by structural brain imaging markers [0.03%]
载脂蛋白ε4和晚年认知能力：结构脑影像标志物的中介作用
Yuan Ma,Gautam Sajeev,Tyler J VanderWeele et al.
Yuan Ma et al.
The apolipoprotein E allele 4 (APOE-ε4) is established as a major genetic risk factor for cognitive decline and late-onset Alzheimer's disease. Accumulating evidence has linked ε4 carriership to abnormal structural brain changes across th...
Relationship between chocolate consumption and overall and cause-specific mortality, systematic review and updated meta-analysis [0.03%]
关于巧克力消耗与全因及特定原因死亡率之间关系的系统回顾和荟萃分析更新
Bin Zhao,Lu Gan,Kai Yu et al.
Bin Zhao et al.
Chocolate is a rich dietary source of various bioactive flavonoid compounds. Despite being one of the most popular foods worldwide, the association between chocolate consumption and long-term mortality remains unclear. The objective of this...