A phenome-wide association study of genetically determined nicotine metabolism reveals novel links with health-related outcomes [0.03%]
全表型组关联分析揭示了遗传性尼古丁代谢与健康结局之间的新联系
Jadwiga Buchwald,Terho Lehtimäki,Olli Raitakari et al.
Jadwiga Buchwald et al.
Faster nicotine metabolism, defined as the nicotine metabolite ratio (NMR), is known to associate with heavier smoking and challenges in smoking cessation. However, the broader health implications of genetically determined nicotine metaboli...
COVID-19 infection increases the risk of venous thromboembolism during pregnancy and the postpartum period [0.03%]
新冠肺炎感染增加妊娠期和产后静脉血栓栓塞的风险
Anne K Örtqvist,Jonas Söderling,Maria C Magnus et al.
Anne K Örtqvist et al.
Pregnant and puerperal women are at increased risk of venous thromboembolism (VTE) owing to hemostatic changes in preparation for childbirth. The objective of this study was to investigate if COVID-19 infection was associated with VTE in pr...
Hormonal contraceptive use and anaemia: a nation-wide pharmacoepidemiological study from Northern Europe [0.03%]
避孕药使用与贫血的相关性：一项来自北欧的全国性药物流行病学研究
Sofie Ekroos,Elena Toffol,Oskari Heikinheimo et al.
Sofie Ekroos et al.
The WHO aims to reduce iron deficiency anaemia globally. Use of modern hormonal contraception (HC) could offer protection against anaemia in premenopausal women, but population-level effectiveness is unclear. We aim to quantify the effect o...
Oral contraceptive use increases bone density and reduces the risk of osteoporosis [0.03%]
口服避孕药的使用可以增加骨密度并降低患骨质疏松症的风险
Emma L Ivansson,Therese Johansson,Torgny Karlsson et al.
Emma L Ivansson et al.
Osteoporotic fractures, largely resulting from reduced estrogen levels after menopause and subsequent bone loss, are a leading cause of disability among older women. Although oral contraceptive pills (OCPs) contain estrogen, their long-term...
Looking at randomized trials with the critical eyes of epidemiologists: the case of screening colonoscopy [0.03%]
流行病学家眼中的随机试验：以结肠镜筛查为例
Hermann Brenner,Thomas Heisser,Michael Hoffmeister
Hermann Brenner
Based on compelling evidence from observational epidemiological studies, screening colonoscopy has since long been thought to strongly lower the burden of colorectal cancer (CRC), both by early detection of prevalent CRC and prevention of i...
Breast Cancer Information Grand Round for Survivorship (BIG-S) prospective cohort [0.03%]
乳腺癌生存资讯大讲堂(BIG-S)前瞻性队列研究
Danbee Kang,Juwon Park,Hyunsoo Kim et al.
Danbee Kang et al.
Existing evidence indicates that long-term effects of breast cancer treatment can significantly impact survivors' ability to fulfill their personal, familial, and social roles. However, few studies comprehensively integrate patient-reported...
Revisiting the hazards of hazard ratios through simulations and case studies [0.03%]
通过模拟和案例研究重新审视风险比的危害
Michal Abrahamowicz,Marie-Eve Beauchamp,Emily K Roberts et al.
Michal Abrahamowicz et al.
The hazard has been a central concept in the analysis and interpretation of time-to-event data for over 50 years. At any follow-up time, the hazard is the probability of the event happening in the next unit of time amongst those still at ri...
Use of systemic hormonal contraception and risk of depression: a registry-based study from Finland [0.03%]
系统使用全身性激素类避孕药与抑郁症风险增加的关系：一项来源于芬兰的登记队列研究
Elena Toffol,Timo Partonen,Oskari Heikinheimo et al.
Elena Toffol et al.
Earlier findings on the relationship between use of hormonal contraception (HC) and depressive symptoms and disorders are contradictory. Thus, we assessed the associations of use of different types of systemic hormonal contraceptives in the...
Ingestion of titanium dioxide as an excipient in medicines and the risk of cancer: a nationwide study within the French National health data system [0.03%]
用作药物赋形剂的二氧化钛摄入与癌症风险：法国全民健康数据库中的全国范围研究
Manon Cairat,Gianluca Severi,Inge Huybrechts et al.
Manon Cairat et al.
Concerns about the safety of titanium dioxide (TiO2), including potential carcinogenicity, have prompted its ban in foods in the European Union, while remaining allowed as pharmaceutical excipient. We aimed to evaluate whether ingesting inc...
TransplantLines, a biobank and cohort study of solid organ transplant recipients and donors [0.03%]
移植受者与捐献者生物样本库及队列研究（TransplantLines）
Anna M Posthumus,Tim J Knobbe,Daan Kremer et al.
Anna M Posthumus et al.
The TransplantLines Biobank and Cohort Study (NCT03272841) is an ongoing prospective study conducted at the University Medical Centre Groningen, The Netherlands. TransplantLines aims to identify risk factors and biomarkers associated with h...