Metabolic profiling of smoking, associations with type 2 diabetes and interaction with genetic susceptibility [0.03%]
吸烟的代谢谱型及其与2型糖尿病的关系和遗传易感性的相互作用
Yuxia Wei,Sara Hägg,Jonathan K L Mak et al.
Yuxia Wei et al.
Background: Smokers are at increased risk of type 2 diabetes (T2D), but the underlying mechanisms are unclear. We investigated if the smoking-T2D association is mediated by alterations in the metabolome and assessed poten...
A prospective study of smoking-related white blood cell DNA methylation markers and risk of bladder cancer [0.03%]
一项关于吸烟相关白细胞DNA甲基化标记物与膀胱癌风险的前瞻性研究
Roel Vermeulen,Barbara Bodinier,Sonia Dagnino et al.
Roel Vermeulen et al.
Bladder cancer, a common neoplasm, is primarily caused by tobacco smoking. Epigenetic alterations including DNA methylation have the potential to be used as prospective markers of increased risk, particularly in at-risk populations such as ...
Prevalence of functional disorders across Europe: a systematic review and meta-analysis [0.03%]
欧洲各地区功能性疾病流行趋势的系统评价及meta分析研究
Caroline Rometsch,Giovanni Mansueto,Frederic Maas Genannt Bermpohl et al.
Caroline Rometsch et al.
Functional Disorders (FD) refer to persistent somatic symptoms caused by changes in the functioning of bodily processes. Previous findings suggest that FD are highly prevalent, but overall prevalence rates for FD in European countries are s...
Life-course social participation and physical activity in midlife: longitudinal associations in the 1970 British Cohort Study (BCS70) [0.03%]
一生中的社会参与和中年时期的体育活动：1970英国队列研究（BCS70）的纵向相关性
Stergiani Tsoli,Daisy Fancourt,Alice Sullivan et al.
Stergiani Tsoli et al.
A hypothesized benefit of social participation is that it encourages people to be more physically active. However, limited evidence exists on the association between social participation over the life-course and physical activity in midlife...
Diabetes and the risk of bladder cancer subtypes in men and women: results from the Netherlands Cohort Study [0.03%]
糖尿病和男女膀胱癌各亚型发病风险：来自荷兰队列研究的结果
Piet A van den Brandt
Piet A van den Brandt
Meta-analyses have shown modest positive associations between diabetes mellitus (DM) and bladder cancer risk, but results are heterogeneous. This might be due to lack of distinction between bladder cancer subtypes, between sexes, and possib...
Allen J Wilcox,Jonathan M Snowden,Kelly Ferguson et al.
Allen J Wilcox et al.
Using the global randomization test as a Mendelian randomization falsification test for the exclusion restriction assumption [0.03%]
使用全局随机测试作为孟德尔随机化排除限制假设的伪命题测试
Louise A C Millard,George Davey Smith,Kate Tilling
Louise A C Millard
Mendelian randomization may give biased causal estimates if the instrument affects the outcome not solely via the exposure of interest (violating the exclusion restriction assumption). We demonstrate use of a global randomization test as a ...
Christoffer Polcwiartek,Mikkel Porsborg Andersen,Helle Collatz Christensen et al.
Christoffer Polcwiartek et al.
The electrocardiogram (ECG) is a non-invasive diagnostic tool holding significant clinical importance in the diagnosis and risk stratification of cardiac disease. However, access to large-scale, population-based digital ECG data for researc...
Antihypertensive drug targets and breast cancer risk: a two-sample Mendelian randomization study [0.03%]
抗高血压药物靶点与乳腺癌风险：双向孟德尔随机化研究
Guoqiao Zheng,Subhayan Chattopadhyay,Jan Sundquist et al.
Guoqiao Zheng et al.
Findings on the correlation between the use of antihypertensive medication and the risk of breast cancer (BC) have been inconsistent. We performed a two-sample Mendelian randomization (MR) using instrumental variables to proxy changes in ge...