Non-linear Mendelian randomization: detection of biases using negative controls with a focus on BMI, Vitamin D and LDL cholesterol [0.03%]
非线性孟德尔随机化：利用阴性对照发现BMI、维生素D和LDL胆固醇的偏差
Fergus W Hamilton,David A Hughes,Wes Spiller et al.
Fergus W Hamilton et al.
Mendelian randomisation (MR) is an established technique in epidemiological investigation, using the principle of random allocation of genetic variants at conception to estimate the causal linear effect of an exposure on an outcome. Extensi...
Stephen Burgess
Stephen Burgess
Serum neurofilament light chain as a prognostic marker of all-cause mortality in a national sample of US adults [0.03%]
美国成年人全国样本中血清神经丝轻链作为全因死亡率预测标志物的研究
May A Beydoun,Nicole Noren Hooten,Michael F Georgescu et al.
May A Beydoun et al.
Neurofilament light chain (NfL) is a neuron-specific structural protein released into the extracellular space, including body fluids, upon neuroaxonal damage. Despite evidence of a link in neurological disorders, few studies have examined t...
The perpetual need of randomized clinical trials: challenges and uncertainties in emulating the REDUCE-AMI trial [0.03%]
REDUCE-AMI试验的模拟：挑战与不确定性及其临床试验的持续需求
Maarten J G Leening,Eric Boersma
Maarten J G Leening
Trial emulations in observational data analyses can complement findings from randomized clinical trials, inform future trial designs, or generate evidence when randomized studies are not feasible due to resource constraints and ethical or p...
Learning about treatment effects in a new target population under transportability assumptions for relative effect measures [0.03%]
基于相对效应度量的外推性假设下的新目标人群中的处理效应学习问题
Issa J Dahabreh,Sarah E Robertson,Jon A Steingrimsson
Issa J Dahabreh
Investigators often believe that relative effect measures conditional on covariates, such as risk ratios and mean ratios, are "transportable" across populations. Here, we examine the identification of causal effects in a target population u...
Prospective benchmarking of an observational analysis in the SWEDEHEART registry against the REDUCE-AMI randomized trial [0.03%]
SWEDEHEART注册登记观察数据与REDUCE-AMI随机对照试验的基准对照研究
Anthony A Matthews,Issa J Dahebreh,Conor J MacDonald et al.
Anthony A Matthews et al.
Prospective benchmarking of an observational analysis against a randomized trial increases confidence in the benchmarking process as it relies exclusively on aligning the protocol of the trial and the observational analysis, while the trial...
Correction: Impact of organised colorectal cancer screening on age-specific population incidences: evidence from a quasi-experimental study in Sweden [0.03%]
纠正：组织型结直肠癌筛查对人口年龄特异发病率的影响：来自瑞典准实验研究的证据
Gabriella Chauca Strand,Ulf Strömberg,Anna Forsberg et al.
Gabriella Chauca Strand et al.
Published Erratum
European journal of epidemiology. 2024 Jun;39(6):697-699. DOI:10.1007/s10654-024-01115-7 2024
Kaili Yang,Xiaotian Liu,Liyan Xu et al.
Kaili Yang et al.
The Chinese keratoconus (CKC) cohort study is a population-based longitudinal prospective cohort study in the Chinese population involving a clinical database and biobanks. This ongoing study focuses on the prevention of KC progression and ...
Differences in metabolomic profiles between Black and White women in the U.S.: Analyses from two prospective cohorts [0.03%]
美国黑人和白人妇女代谢组学特征的差异：来自两项前瞻性队列研究的分析
Emma E McGee,Oana A Zeleznik,Raji Balasubramanian et al.
Emma E McGee et al.
There is growing interest in incorporating metabolomics into public health practice. However, Black women are under-represented in many metabolomics studies. If metabolomic profiles differ between Black and White women, this under-represent...
A multidisciplinary and structured investigation of three suspected clusters of transverse upper limb reduction defects in France [0.03%]
法国三例疑似横痃上肢残缺缺陷群的多学科结构调查
Julie Boudet-Berquier,Christophe Demattei,Laurence Guldner et al.
Julie Boudet-Berquier et al.
Introduction: Between 2019-2021, facing public concern, a scientific expert committee (SEC) reanalysed suspected clusters of transverse upper limb reduction defects (TULRD) in three administrative areas in France, where i...