Competing Risks, Renal Function, and Register Completeness: Methodological Considerations for Drug-Drug Interactions in Older Adults with Atrial Fibrillation [0.03%]
竞争风险、肾功能和登记完整性：老年人房颤药物相互作用的方法学考虑因素
Muhammad Adil Choudhry
Muhammad Adil Choudhry
Unveiling the miR‑26a‑5p/MSMO1/7‑DHC Axis: A Novel Therapeutic Target in Myocardial Ischemia-Reperfusion Injury [0.03%]
揭示miR-26a-5p/MSMO1/7-DHC轴：心肌缺血再灌注损伤的新治疗靶点
Yonglin Fu,Bingjie Han,Jiankai Zhang et al.
Yonglin Fu et al.
Ferroptosis plays a critical role in myocardial ischemia-reperfusion injury (MIRI). Here, we discovered that MSMO1, a key enzyme in the cholesterol biosynthesis pathway, regulates ferroptosis in MIRI, and identified miR-26a-5p as an upstrea...
Lentinan Attenuates Experimental Atherosclerosis by Regulating Macrophage HCK/GUSB Expression and Amino Acid Metabolic Remodeling [0.03%]
香菇多糖通过调节巨噬细胞HCK/GUSB表达和氨基酸代谢重塑缓解实验性动脉粥样硬化
Guoling Rong,Jiaolong Yu,Cai Jing et al.
Guoling Rong et al.
Atherosclerosis (AS) is a chronic inflammatory vascular disease characterized by lipid accumulation, immune activation, and plaque formation. This study investigated the anti-atherosclerotic effects of Lentinan (LNT) and explored its potent...
Stroke Heart Syndrome: Neuroimmune and Metabolic Crosstalk with Conceptual Approaches for Precision Therapeutics [0.03%]
卒中性心综合征：神经免疫和代谢交叉对话及精准治疗的概念方法
Qiwen Nie,Wang Guo,Zhihao Wang et al.
Qiwen Nie et al.
Background: Stroke-heart syndrome (SHS) represents a serious complication after stroke that significantly elevates mortality risk, especially in the short term. The primary initiating pathological event in SHS is acute is...
Endpoint Inconsistency and Overinterpretation of Early Biomarkers After CABG [0.03%]
冠脉搭桥术后终点不一致及早期生物标志物过度解读
Yuxin Sheng,Le Wen
Yuxin Sheng
PRMT2 Aggravates Pressure Overload-induced Cardiac Remodeling by Promoting Endothelial Phenotypic Transition via Snail1 Methylation [0.03%]
脯氨酸-精氨特异性甲基转移酶2通过促进血管内皮向间充质转变加重压力超负荷诱导的心脏重塑
Xianwei Fan,Xuejie Li,Juan Hu et al.
Xianwei Fan et al.
Purpose: Endothelial-to-mesenchymal transition (EndMT) is implicated in cardiac remodeling under pathological stress, although its full in vivo occurrence may be context-dependent. Emerging evidence suggests that protein ...
Effects of Age, BMI and Creatinine Clearance on Edoxaban Plasma Concentrations in Non-Valvular Atrial Fibrillation Patients [0.03%]
年龄、体重指数和肌酐清除率对非瓣膜性房颤患者艾多沙班血药浓度的影响
Mengxue Li,Jie He,Gaoqiu Dong et al.
Mengxue Li et al.
Purpose: Non-valvular atrial fibrillation (NVAF) is a major stroke risk factor, and edoxaban is commonly used for thromboprophylaxis. However, marked interindividual variability in plasma edoxaban exposure may raise bleed...
Finerenone After FINE-ONE and CONFIDENCE: Updating the Cardiorenal-Metabolic Treatment Paradigm Beyond Type 2 Diabetes [0.03%]
芬瑞诺酮用于糖尿病肾病患者——基于FINE-ONE和CONFIDENCE试验更新心肾代谢治疗理念超越2型糖尿病
Siddarth Raajasekar
Siddarth Raajasekar
Cellular Senescence in Diabetic Cardiomyopathy: Mechanistic Insights and Therapeutic Perspectives [0.03%]
糖尿病心肌病中的细胞衰老：机制见解和治疗前景
Ting Ye,Donglin Yang,Xinrui Chang et al.
Ting Ye et al.
Diabetic cardiomyopathyis a distinct cardiac disorder marked by diabetes-associated myocardial structural and functional abnormalities, developing independently of other overt cardiovascular diseases. Mounting evidence suggests that cellula...