Microenvironment matters: insights from the FOSTER consortium on microenvironment-driven approaches to osteosarcoma therapy [0.03%]
微环境影响骨肉瘤治疗：FOSTER联盟关于微环境驱动治疗方法的见解
Aurelie Dutour,Michela Pasello,Luke Farrow et al.
Aurelie Dutour et al.
Osteosarcoma (OS), a prevalent malignant bone tumor, has seen limited progress in treatment efficacy and patient outcomes over decades. Recent insights into the tumor microenvironment (TME) have revealed its crucial role in tumor progressio...
Lessons learned from a decade of immune checkpoint inhibition: The good, the bad, and the ugly [0.03%]
免疫检查点抑制剂十年临床应用经验教训——好的、坏的和丑陋的
Jacob J Adashek,Jillian A Moran,Dung T Le et al.
Jacob J Adashek et al.
Discovering the brakes/checkpoints that cancer places on the immune system to prevent being eradicated led to the 2018 Nobel Prize and the development of multiple Food and Drug Administration-approved immune checkpoint inhibitors (ICIs). IC...
Microbiota and cancer: unraveling the significant influence of microbial communities on cancer treatment [0.03%]
微生物群与癌症：解析微生物群对癌症治疗的重要影响
R Paul Wilson,Lori Rink,Çagla Tükel
R Paul Wilson
Prostate cancer-specific proinflammatory cytokines and chemokines impact on cancer stem cell development, lineage plasticity and heterogeneity in an Ancestral/racially diverse population: review [0.03%]
前列腺癌特异性促炎细胞因子和趋化因子在祖/种族多样化人群中对癌症干细胞的发育，谱系可塑性和异质性的影响：综述
Powell Isaac,Hudson Cullen,Teslow Emily et al.
Powell Isaac et al.
Since 1976, Surveillance Epidemiology End Results (SEER) began collecting ethnicity data for the National Cancer Institute. The incidence of prostate cancer (PCa) among African American men (AAM) has been 60-70% higher than any other ethnic...
VCAM-1 as a common biomarker in inflammatory bowel disease and colorectal cancer: unveiling the dual anti-inflammatory and anti-cancer capacities of anti-VCAM-1 therapies [0.03%]
VCAM-1作为炎症性肠病和结直肠癌的共同生物标志物：揭示抗VCAM-1疗法的双重抗炎抗癌能力
Jessica R Pickett,Yuao Wu,Hang Thu Ta
Jessica R Pickett
Vascular cell adhesion molecule (VCAM)-1 has garnered significant research attention due to its potential as a disease biomarker and drug target across several inflammatory pathologies-including atherosclerosis, asthma, rheumatoid arthritis...
Using ultrasound and microbubble to enhance the effects of conventional cancer therapies in clinical settings [0.03%]
使用超声和微泡来提高常规癌症治疗在临床设置中的效果
Deepa Sharma,Gregory J Czarnota
Deepa Sharma
It has been demonstrated in preclinical research that the administration of microbubbles with ultrasound can augment the proapoptotic sphingolipid pathway and enhance chemotherapy or radiation therapy-induced vascular endothelial disruption...
The functions and modifications of tRNA-derived small RNAs in cancer biology [0.03%]
肿瘤生物学中tRNA来源的小RNA的功能和修饰
Abdulaziz Ahmed A Saad,Kun Zhang,Qianqian Deng et al.
Abdulaziz Ahmed A Saad et al.
Recent progress in noncoding RNA research has highlighted transfer RNA-derived small RNAs (tsRNAs) as key regulators of gene expression, linking them to numerous cellular functions. tsRNAs, which are produced by ribonucleases such as angiog...
Amila Suraweera,Kenneth J O&#x;Byrne,Derek J Richard
Amila Suraweera
Genetic and epigenetic modifications of DNA are involved in cancer initiation and progression. Epigenetic modifications change chromatin structure and DNA accessibility and thus affect DNA replication, DNA repair and transcription. Epigenet...
Jaewang Lee,Jong-Lyel Roh
Jaewang Lee
Ferroptosis, an iron-dependent form of cell death, has been the focus of extensive research over the past decade, leading to the elucidation of key molecules and mechanisms involved in this process. While several studies have highlighted ir...
Monocyte-related markers as predictors of immune checkpoint inhibitor efficacy and immune-related adverse events: a systematic review and meta-analysis [0.03%]
单核细胞相关标志物作为预测免疫检查点抑制剂有效性和免疫相关不良事件的指标：系统回顾和荟萃分析
Aiarpi Ezdoglian,Michel Tsang-A-Sjoe,Fatemeh Khodadust et al.
Aiarpi Ezdoglian et al.
The efficacy and off-target effects of immune checkpoint inhibitors (ICI) in cancer treatment vary among patients. Monocytes likely contribute to this heterogeneous response due to their crucial role in immune homeostasis. We conducted a sy...