Laurine Lagache,Michel Salzet
Laurine Lagache
Multicellular organisms are not just collections of cells; they are evolutionary compromises in which cell-level fitness is subordinated to organism-level integrity. Cancer begins when that compromise is locally subverted, but metastasis is...
HER2 assessment in urothelial carcinoma: standardization challenges and the path forward [0.03%]
尿路上皮癌中的HER2评估：标准化挑战及未来方向
Peipei Xie,Yajie Wang,Lei Lu et al.
Peipei Xie et al.
Human epidermal growth factor receptor 2 (HER2) is a crucial oncogenic factor, highly expressing in various cancers, with urothelial carcinoma (UC) showing one of the highest levels of HER2 overexpression. HER2 serves as an ideal therapeuti...
Resolving translational challenges in cancer biology through yeast experimental evolution [0.03%]
通过酵母实验进化解决癌症生物学中的翻译挑战
Li-Tzu Wang,Han-Ying Jhuang
Li-Tzu Wang
Cancer genomics, molecular pathology, targeted therapy, and immunotherapy have transformed how tumors are diagnosed and treated, yet several problems remain hard to resolve prospectively, including the interpretation of variants of uncertai...
Spheroids and organoids to study long noncoding RNAs in cancer: how they could replace animal models [0.03%]
用于癌症研究的类器官和器官样体：它们如何替代动物模型？
Ana Maria Capela,João Pessoa,Hugo Arede et al.
Ana Maria Capela et al.
Spheroids, organoids, and further three-dimensional cellular models represent an intermediate stage of supra-cellular complexity between monolayered cell cultures and animal models. In the present review, we identified conditions in which s...
Strategies and successes of smoking cessation methods in head and neck cancer patients: a systematic review [0.03%]
头颈癌患者的戒烟方法及其效果：系统综述
Vincent Vander Poorten,Justine Van Rossum,Malene Roosens et al.
Vincent Vander Poorten et al.
Tobacco use and especially smoking tobacco is a key risk factor in the development and the progression of head and neck squamous cell carcinoma (HNSCC). Continued smoking after diagnosis worsens treatment outcomes, survival rates, and quali...
The Hippo signaling pathway in pediatric brain tumors: molecular mechanisms and therapeutic opportunities [0.03%]
儿童脑肿瘤中的Hippo信号通路：分子机制和治疗机会
Maria A Papanikolaou,Antonios N Gargalionis,Christos Adamopoulos et al.
Maria A Papanikolaou et al.
Pediatric brain tumors are the second most prevalent malignancy in children with therapeutic options remaining challenging due to vulnerability of the developing brain and the significant side effects of current treatment with targeted ther...
Antibody-drug conjugates in breast cancer brain and leptomeningeal metastases: mechanistic insights and therapeutic progress [0.03%]
抗体-药物偶联物在乳腺癌脑和蛛网膜下腔转移中的机制见解和治疗进展
Hanqi Zhang,Yaqing Qin,Hanzhi Chu et al.
Hanqi Zhang et al.
Antibody-drug conjugates (ADCs) are targeted therapies that employ monoclonal antibodies to deliver potent cytotoxic agents to cancer cells. The treatment of breast cancer with brain and leptomeningeal metastases has long been limited by th...
Prognostic, diagnostic and therapeutic value of the cancer tubulin code [0.03%]
癌症微管蛋白密码的预后、诊断和治疗价值评估
Carolina Vilela,Daniela Gomes-Andrade,Sónia Silva et al.
Carolina Vilela et al.
Microtubules are essential cytoskeleton polymers composed of α/β-tubulin heterodimers that play a central role in the regulation of various cellular processes, including cell division, cell shape, cell polarity, motility and intracellular...
Mechanobiology of solid tumor vasculature: implications for tumor progression [0.03%]
固体肿瘤血管的力学生物学：对肿瘤进展的影响
Raghu Vamsi Kondapaneni,Sarah Libring,Sid Dsa et al.
Raghu Vamsi Kondapaneni et al.
Under normal physiological conditions, the vasculature forms a selective barrier that regulates molecular and cellular transport, largely maintained through vascular endothelial cadherin (VE-cadherin)-mediated junctions formed by endothelia...
Antibody-drug conjugates in cancer therapy: do we need biomarkers? A comprehensive review [0.03%]
抗体药物偶联物抗癌治疗中是否需要生物标志物？全面回顾
Lei Lei,Ya-Bing Zheng,Shou-Ching Tang
Lei Lei
Antibody-drug conjugates (ADCs) have revolutionized targeted cancer therapy, yet a fundamental clinical contradiction remains: while some ADCs require strict companion diagnostic testing, others demonstrate robust efficacy in biomarker-nega...