Opioid use and the risk of cancer incidence and mortality: a systematic review [0.03%]
阿片类药物使用与癌症发病和死亡风险的关联：系统评价研究报告
Shakti Shrestha,Holly Foot,Mahdi Sheikh et al.
Shakti Shrestha et al.
There is abundant but discrepant scientific literature reporting an effect of opioids on the course of cancer. The International Agency for Research on Cancer monographs recently classified opium consumption as carcinogenic to humans in cer...
The invadosome of stem-like cancer cells: metastasis machinery and targetable vulnerability [0.03%]
类癌干细胞的invadosome：转移机器与靶向脆弱性
Kelvin K Tsai
Kelvin K Tsai
Despite recent advances in targeted and immuno-therapy, metastasis still kills most cancer patients. Overcoming cancer metastasis requires a leap forward in understanding its molecular underpinnings to identify breakthrough therapeutic targ...
Novel immunotherapy for gastric cancer: targeting the CD47-SIRPα axis [0.03%]
胃癌新型免疫疗法：靶向CD47-SIRPα轴
Akira Ooki,Hiroki Osumi,Keitaro Shimozaki et al.
Akira Ooki et al.
Gastric cancer (GC) represents a significant global health challenge, with limited therapeutic options and poor outcomes. Although cancer immunotherapies targeting adaptive immune checkpoints, such as programmed death-1, have transformed th...
Nanomaterials in cancer starvation therapy: pioneering advances, therapeutic potential, and clinical challenges [0.03%]
癌症饥饿疗法中的纳米材料：开拓性进展、治疗潜力和临床挑战
Nam Anh Tran,Shehzahdi S Moonshi,Alfred K Lam et al.
Nam Anh Tran et al.
Gaining significant attention in recent years, starvation therapy based on the blocking nutrients supply to cancer cells via blood occlusion and metabolic interventions is a promisingly novel approach in cancer treatment. However, there are...
Molecular mechanisms of metastatic peritoneal dissemination in gastric adenocarcinoma [0.03%]
胃腺癌腹膜转移的分子机制
Deanna Ng,David Cyr,Shawn Khan et al.
Deanna Ng et al.
Peritoneal dissemination portends a dismal prognosis in patients with gastric adenocarcinoma in the context of limited effective treatments. The underlying cellular processes that drive gastric peritoneal carcinomatosis remain unclear, limi...
Metal-modulated T cell antitumor immunity and emerging metalloimmunotherapy [0.03%]
金属调控的T细胞抗肿瘤免疫和金属免疫疗法的新进展
Peiyun Liao,Ying Zhou,Yingqi Qiu et al.
Peiyun Liao et al.
In recent years, increasing evidence has shown that metals play important roles in both innate and adaptive immunity. An emerging concept of metalloimmunotherapy has been proposed, which may accelerate the development of immunotherapy for c...
Lactate metabolism and lactylation in breast cancer: mechanisms and implications [0.03%]
乳腺癌中的乳酸代谢和乳酰化：机制及意义
Yifan Qiao,Yijia Liu,Ran Ran et al.
Yifan Qiao et al.
As the end-product of glycolysis, lactate serves as a regulator of protein lactylation in addition to being an energy substrate, metabolite, and signaling molecule in cancer. The reprogramming of glucose metabolism and the Warburg effect in...
CAR T-cells for acute leukemias in children: current status, challenges, and future directions [0.03%]
儿童急性白血病CAR-T细胞治疗的现状、挑战与未来方向
Marie Emilie Dourthe,André Baruchel
Marie Emilie Dourthe
CAR T-cells therapy is seen as one of the most promising immunotherapies for leukemias, since targeting CD19 has revolutionized the treatment of relapsed/refractory B-cell acute lymphoblastic leukemia (B-ALL) in children, adolescents, and y...
Rani Pallavi,Bihari Lal Soni,Gaurab Kumar Jha et al.
Rani Pallavi et al.
Tumor heterogeneity, characterized by the presence of diverse cell populations within a tumor, is a key feature of the complex nature of cancer. This diversity arises from the emergence of cells with varying genomic, epigenetic, transcripto...
State-of-the-art of multidisciplinary approach of bone metastasis-directed therapy: review and challenging questions for preparation of a GEMO practice guidelines [0.03%]
骨转移综合治疗最新进展及GEMO实践指南制定中的关键问题挑战性分析
Emmanuel Mesny,Nicolas Martz,Nicolas Stacoffe et al.
Emmanuel Mesny et al.
Bone is a common secondary site of dissemination during the course of cancer. Bone metastases (BM) can be associated with skeletal-related events (SRE) such as disabling pain, hypercalcemia, and bone instability that leads to pathological f...