Socioeconomic impact of artificial intelligence-driven point-of-care testing devices for liquid biopsy in the OncoCheck system [0.03%]
OncoCheck系统中基于人工智能的液态活检即时检测设备的社会经济影响
Sima Singh,Ada Raucci,Alessandra Glovi et al.
Sima Singh et al.
Cancer disparities in low- and middle-income countries (LMICs) persist because of socioeconomic inequalities and limited access to screening infrastructure, which requires equitable diagnostic solutions. As researchers, we need to develop i...
Macrophage regulation of tumor cell dormancy and the dormant niche: an overview in solid tumors [0.03%]
肿瘤巨噬细胞调节肿瘤细胞休眠和休眠生态位：实体瘤中的概述
Hongxing Zhang,Yiyue Ding,Lihui Gu et al.
Hongxing Zhang et al.
Tumor recurrence often occurs years after initial treatment, driven by dormant tumor cells that evade detection and therapy. These quiescent cells can persist in primary or metastatic niches and later reawaken under favorable microenvironme...
Optimal choice of different neoadjuvant chemoradiotherapies for locally advanced rectal cancer: systematic review and network meta-analysis [0.03%]
局部晚期直肠癌不同新辅助放化疗方案的最佳选择：系统评价和网状Meta分析
Lian Liu,Guangyu Yao,Junhao Yang et al.
Lian Liu et al.
The objective of this study is to compare the pathological complete response (pCR) and survival rates of different neoadjuvant chemoradiotherapy modalities (NACRT) for locally advanced rectal cancer, which is defined as rectal cancer with T...
Astrocyte involvement in brain metastasis: from biological mechanisms to therapeutic strategies [0.03%]
星形胶质细胞在脑转移中的作用：从生物学机制到治疗策略
Teng Zhou,Yuxin Yan,Mingxi Lin et al.
Teng Zhou et al.
BrMs represent a significant clinical challenge due to its high incidence, complex biology, and poor prognosis. Astrocytes, the predominant glial cells in the central nervous system, are increasingly recognized for their central role in sha...
Sergei Kusmartsev
Sergei Kusmartsev
The tumor metastatic dissemination and colonization is a highly complex, multi-step process that requires cooperation between cancer and host cells. Among these, cells of myeloid lineage mobilized from the bone marrow are crucial in facilit...
Mark Samuels,Simoni Besta,Andrea Lauer Betrán et al.
Mark Samuels et al.
The emergence of CRISPR-Cas9 technology has transformed functional genomics, offering unmatched opportunities to dissect and understand biological pathways and identify novel therapeutic targets in cancer. Breast cancer is a complex, hetero...
Tissue-agnostic biomarkers in solid tumors: current approvals and emerging candidates [0.03%]
实体瘤中的组织不可知型生物标志物：当前已获批的和新兴的候选者
Jinah Kim,Hye Sung Kim,Myungwoo Nam et al.
Jinah Kim et al.
The landscape of cancer treatment has shifted from histology-specific to tissue-agnostic approaches, targeting molecular alterations regardless of tumor origin. Currently, six pan-cancer biomarkers-NTRK, BRAF V600E, RET, HER2-positive, MSI-...
Prospects and limitations of NK cell adoptive therapy in clinical applications [0.03%]
自然杀伤细胞临床应用的前景与局限性
Yamin Deng,Chen Wu,Jintong Na et al.
Yamin Deng et al.
During the last three decades, there has been substantial advancement in comprehending the chemical attributes and roles of natural killer (NK) cells, resulting in a growing interest in these cells. Simultaneously, the swift advancement of ...
Shaping the battlefield: EGFR and KRAS tumor mutations' role on the immune microenvironment and immunotherapy responses in lung cancer [0.03%]
塑造战场：EGFR和KRAS肿瘤突变在肺癌免疫微环境及免疫治疗反应中的作用
Bassel Alsaed,Nina Bobik,Hanna Laitinen et al.
Bassel Alsaed et al.
The two most common and mutually exclusive driver mutations in non-small cell lung cancer affect EGFR and KRAS oncogenes. While EGFR mutations typically arise in non-smokers and are correlated with non-inflamed tumor microenvironment, KRAS ...
Kishore Banik,Thomas J Hayman
Kishore Banik
Genomic instability is a hallmark of cancer and is associated with tumor progression and therapeutic resistance. Centrioles and centrosomes are a critical determinant of genomic stability. Polo-like kinase 4 (PLK4) is a serine-threonine kin...