Lung cancer in non-smoking women (LCINSW): from risk factors to precision therapy [0.03%]
非吸烟女性肺癌（LCINSW）从危险因素到精准治疗
Jinming Zhao,Mingjun Li,Limin Niu et al.
Jinming Zhao et al.
Non-smoking lung cancer, characterized by early onset and predominant EGFR mutations, has been listed as a separate disease entity and is the seventh leading cause of cancer-related death worldwide. Its incidence remains a significant healt...
The Bermuda Triangle of paediatric brain cancers: epigenetics, developmental timing window and cell of origin [0.03%]
儿童脑瘤的 Bermuda Triangle：表观遗传学、发育时间窗口和起源细胞
Afraah Cassim,Yolanda Colino-Sanguino,Sarah L Fox et al.
Afraah Cassim et al.
Paediatric brain cancers are aggressive tumours that urgently need deeper understanding of their cellular and molecular vulnerabilities to facilitate the development of effective treatments. These tumours frequently arise from epigenetic al...
Elise Young,Barnaby Kelly,Jason E Cain
Elise Young
Childhood sarcomas are an aggressive and diverse group of mesenchymal-origin malignancies that collectively account for over a third of paediatric solid tumours. There has been little progress made in the treatment of childhood sarcomas in ...
Arundhati Chaudhary,Kayleigh J A Orchard,Francesca Salani et al.
Arundhati Chaudhary et al.
Phenotypic plasticity is a key mechanism of metastatic progression and cancer therapy resistance. This hallmark of human malignancies is enabled by highly conserved epigenetic mechanisms that control gene expression. Functional alterations ...
Perspectives on the origin and therapeutic opportunities in Down syndrome-associated leukemia [0.03%]
唐氏综合征相关白血病的发病机制及治疗机遇展望
Kunjal Panchal,Jesse Armitage,Laurence C Cheung et al.
Kunjal Panchal et al.
It is now well accepted that germline or de novo genetic alterations predispose to cancer development, especially during childhood. Among them, constitutive trisomy 21, also known as Down syndrome (DS), has been shown to predispose to acute...
Turning the tide: harnessing amphiregulin to optimize radiation therapy and prevent metastasis [0.03%]
乘风破浪：利用Amphiregulin优化放疗和预防转移
Aitziber Buqué,Lucia Borriello,Rebecca M Shulman et al.
Aitziber Buqué et al.
Integrins from extracellular vesicles as players in tumor microenvironment and metastasis [0.03%]
来源于细胞外囊泡的整合素在肿瘤微环境和转移中的作用
Corina Ciobanasu,Christophe Le Clainche
Corina Ciobanasu
Integrins constitute a large and diverse family of cell adhesion molecules that play essential roles in regulating tumor cell differentiation, migration, proliferation, and neovascularization. Tumor cell-derived exosomes, a subtype of extra...
Demystifying the link between periodontitis and oral cancer: a systematic review integrating clinical, pre-clinical, and in vitro data [0.03%]
牙周炎和口腔癌之间联系的系统性综述：整合临床、前临床和体外数据
Suzane C Pigossi,Jovânia A Oliveira,Marcell C de Medeiros et al.
Suzane C Pigossi et al.
Chronic inflammation and microbial dysbiosis have been implicated in the development of head and neck squamous cell carcinoma (HNSCC), particularly oral cavity squamous cell carcinoma (OSCC). Periodontitis is a common chronic inflammatory d...
Aleksei G Golubev,Margarita L Tyndyk,Vladimir N Anisimov
Aleksei G Golubev
More than half of cancer patients are over 65 years old. This proportion will increase with further population aging. Cancer properties significantly depend on patients' age, and, as a rule, cancer responsiveness to therapy decreases with p...
Hematological toxicity of parp inhibitors in solid tumors: a systematic review and safety meta-analysis [0.03%]
PARP抑制剂在实体瘤中的血液学毒性：系统性回顾和安全性Meta分析研究
Brigida Anna Maiorano,Martina Catalano,Mauro Francesco Pio Maiorano et al.
Brigida Anna Maiorano et al.
Poly (ADP-ribose) polymerase (PARP) inhibitors (PARPis) are effective agents in different tumor types. A typical class of adverse events (AEs) associated with these agents, often leading to treatment modifications and discontinuations of tr...