The intricate interplay between circadian rhythm, androgen signaling, hormone therapy, and cellular senescence in prostate cancer [0.03%]
前列腺癌中昼夜节律、雄激素信号传导、激素治疗和细胞衰老的复杂相互作用
Mehdi Heidari Horestani,Aria Baniahmad
Mehdi Heidari Horestani
Prostate cancer (PCa) is the second most diagnosed cancer and the fifth leading cause of cancer death among men worldwide. Androgen receptor (AR), as a ligand-activated transcription factor, is important for both prostate development and PC...
Combining radiotherapy and immune checkpoint inhibitors in metastatic cancers: a 25-year review of safety outcomes by the ENRSO Group [0.03%]
放射治疗与免疫检查点抑制剂在转移性癌症中的联合应用：ENRSO 组 25 年的安全性结果回顾分析
Constance Golfier,Aude Visy,Anna Gueiderikh et al.
Constance Golfier et al.
This scoping review evaluates the safety and feasibility of combining immune checkpoint inhibitors (ICIs) with radiotherapy (RT) in metastatic cancers. The analysis focuses on key variables that may influence toxicity, including the site of...
Influence of genetic polymorphisms on gefitinib pharmacokinetics and adverse drug reactions in non-small cell lung cancer patients [0.03%]
吉非替尼药代动力学及不良反应的遗传多态性研究
Prathvi V Shenoy,Gayathri Baburaj,Rama Rao Damerla et al.
Prathvi V Shenoy et al.
Gefitinib is a first-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) used in the treatment of non-small cell lung cancer (NSCLC). It is metabolized extensively in the liver by enzymes encoded by CYP3A4, CY...
Towards a personalized utilization of stereotactic body radiotherapy for the management of liver metastases in solid tumors [0.03%]
立体定向体放射治疗的个体化应用在实体瘤肝转移中的研究进展
Pierre-Antoine Laurent,Kanta Ka,Matthieu Roulleaux Dugage et al.
Pierre-Antoine Laurent et al.
The presence of liver metastases in solid tumors is associated with poor prognosis. This adverse impact on patient outcomes may partly stem from the highly immunosuppressive environment commonly found within hepatic lesions, often resulting...
Functions and clinical implications of the liver microenvironment in hepatic uveal melanoma metastases [0.03%]
肝微环境在肝转移性脉络膜黑色素瘤中的功能及临床意义
Camille J Cunanan,Alyssa B Sanders,Kayla C Gallant et al.
Camille J Cunanan et al.
Uveal melanoma (UM) is an aggressive intraocular malignancy in adults arising from the melanocytes of the uveal tract. While primary UM lesions can be successfully treated, ~ 50% of UM patients develop metastases primarily in the liver. Pat...
Lymphatic metastasis in pancreatic cancer: from bedside to bench and back [0.03%]
胰腺癌的淋巴转移：从床旁到实验研究再回归临床
Haoyu Shi,Cheng Qin,Yutong Zhao et al.
Haoyu Shi et al.
Pancreatic cancer is an extremely aggressive and lethal malignant cancer; almost half of the patients have distant metastasis when first diagnosed, and many challenges arise during treatment. Lymph node metastasis is a vital indicator of di...
Clinical subtypes of stage IV pancreatic ductal adenocarcinoma: a new perspective of clinical practices [0.03%]
IV期胰导管腺癌的临床亚型：新的临床实践视角
Yi-Fei Zhang,Wei Gan,Wen-Quan Wang et al.
Yi-Fei Zhang et al.
Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest malignancies and becomes an increasing burden on our society, with nearly half of patients presenting with metastasis at diagnosis and a mortality rate that continues to r...
B7-H3 in the tumor microenvironment: Implications for CAR T cell therapy in pediatric solid tumors [0.03%]
肿瘤微环境中的B7-H3：对儿童实体瘤CAR-T细胞治疗的启示
Lena Jansen,Judith Wienke,Ronja Molkenbur et al.
Lena Jansen et al.
B7 homolog 3 (B7-H3, CD276) has emerged as a promising target for chimeric antigen receptor (CAR) T cell therapy, with limited expression in normal tissues and high level cell-surface expression across various tumor types. Clinical studies ...
Spatial proteomics for investigating solid tumor resistance mechanisms [0.03%]
空间蛋白质组学在探究实体肿瘤耐药机制中的应用
Xin Ming M Zhou,Anjali J D&#x;Amiano,Charles Lu et al.
Xin Ming M Zhou et al.
Spatial proteomics technologies have been pivotal in profiling tumor immune microenvironments at single-cell resolution, advancing our understanding of cancer biology, identifying key cell populations in solid tumors, and predicting treatme...
Single-cell RNA-sequencing of circulating tumour cells: A practical guide to workflow and translational applications [0.03%]
循环肿瘤细胞单细胞RNA测序：工作流程与转化应用实践指南
Francis Yew Fu Tieng,Learn-Han Lee,Nurul-Syakima Ab Mutalib
Francis Yew Fu Tieng
The global burden of cancer is rising, with treatment failures often due to the metastatic nature of late-stage malignancies. Circulating tumour cells (CTCs) are metastatic precursors shed from primary tumours, which survive in circulation,...