The diverse roles of Hox proteins in the regulation of the cell cycle and their therapeutic value in cancer treatment [0.03%]
Hox蛋白在细胞周期调节中的多种作用及其在癌症治疗中的价值
Lupeuea Vakafua,Lachlan Clifton-Bligh,Naisana Seyedasli
Lupeuea Vakafua
Tissue morphogenesis and homeostasis occur at the interface of a fine coordination between cell cycle and differentiation events. The fundamental role of Hox genes during embryonic development is well established. However, less is known abo...
The dual fate of DYRK2 in cancer: balancing the light and dark side of tumorigenesis [0.03%]
DYRK2在癌症中的双重作用：平衡肿瘤发生中的正反两面
Lucía Suanes-Cobos,Miguel Torres-Ramos,Irene Aguilera-Ventura et al.
Lucía Suanes-Cobos et al.
Dual-specificity tyrosine-phosphorylation-regulated kinase 2 (DYRK2) is emerging as a pivotal player in cancer biology due to its pleiotropic cellular roles, functioning either as a tumor suppressor or an oncogene in a tissue- and genotype-...
Thrombocytosis in cancer patients: when more is not better-in fact, the opposite [0.03%]
肿瘤患者的血小板增多：当更多并非更好时——事实上恰恰相反
Karolina Aleksandrowicz,Barbara Polityńska,Joanna Kruszewska et al.
Karolina Aleksandrowicz et al.
Platelets are key elements of hemostasis which play an important role in pathological processes, especially in the context of cancer. They are small, disc-shaped structures equipped with a rich network of organelles and a cytoskeleton. In h...
One-carbon metabolism in cancer: moonlighting functions of metabolic enzymes and anti-tumor therapy [0.03%]
一碳代谢与肿瘤：代谢酶的多功能性及抗肿瘤治疗策略
Xuedi Cao,Yunyun Guo,Zhengyang Guo et al.
Xuedi Cao et al.
One-carbon (1C) metabolism is a central metabolic network that supports nucleotide biosynthesis, amino acid metabolism, and redox homeostasis, playing a critical role in cellular proliferation. In cancer, dysregulation of this pathway fuels...
Alternate actions of CDK4/6 inhibitors beyond cell cycle blockade: unexplored roles in therapy resistance [0.03%]
CDK4/6抑制剂的细胞周期阻滞以外的多种作用：在耐药中未被探索的角色
Domenica Scordamaglia,Marianna Talia,Azzurra Zicarelli et al.
Domenica Scordamaglia et al.
Cell cycle dysregulation and the aberrant activation of cyclin-dependent kinases (CDKs) lead to uncontrolled cell proliferation; therefore, these events represent well-established hallmarks of cancer. The advent of CDK4/6 inhibitors, namely...
Gui-Xia Wei,Ya-Qin Zhao,Rong Tang et al.
Gui-Xia Wei et al.
Immunotherapy and radiotherapy are widely used in the treatments of various cancers. However, their application remains limited in certain cancer types because only a small number of patients respond to monotherapy. Notably, these two modal...
Circulating tumour cells and circulating tumour DNA in head and neck cancer: from molecular insights to clinical impact [0.03%]
循环肿瘤细胞和循环肿瘤DNA在头颈癌中的作用：从分子认识至临床影响
Sreedevi Damodaran,Chameera Ekanayake Weeramange,Lizbeth Kenny et al.
Sreedevi Damodaran et al.
Head and neck squamous cell cancers (HNSCC) are a clinically and biologically diverse group of malignancies with limited tools for real-time monitoring and early detection of recurrence. Liquid biopsy strategies-particularly the analysis of...
Spatial omics: applications and utility in profiling the tumor microenvironment [0.03%]
空间组学：在肿瘤微环境谱分析中的应用和效用
Ji-Eun See,Sarah Barlow,Wani Arjumand et al.
Ji-Eun See et al.
Spatial transcriptomics has emerged as a transformative technology in biomedical research, offering unprecedented insights into gene and protein expression within their native tissue context. Unlike conventional bulk or single-cell sequenci...
Recent advances and treatment strategies in liver metastasis of pancreatic neuroendocrine tumors [0.03%]
胰腺神经内分泌肿瘤肝转移的治疗进展与策略
Zhiyuan Guo,Xu Han,Jilei Chen et al.
Zhiyuan Guo et al.
Pancreatic neuroendocrine tumors (pNETs) are characterized by significant spatial and temporal heterogeneity, exhibiting a wide spectrum of biological behaviors, histopathological features, and clinical presentations. The presence of liver ...
Advancing small cell lung cancer metastasis research: innovations in preclinical mouse models [0.03%]
促进小细胞肺癌转移研究：临床前小鼠模型的创新
Qiqi Zhao,Liang Hu,Hongbin Ji
Qiqi Zhao
Small cell lung cancer (SCLC) represents one of the most aggressive malignancies, featured with its extraordinary metastatic capacity. Preclinical mouse models have become indispensable systems for studying the molecular mechanisms underlyi...