Dissecting the aberrant vasculature of glioblastoma: mechanisms and therapeutic targets [0.03%]
胶质母细胞瘤异常血管的形成机制及治疗靶点
Yinan Li,Yinfei Du,Fan Guan et al.
Yinan Li et al.
Glioblastoma (GBM) is a highly aggressive and almost incurable tumor of the central nervous system. The GBM microenvironment is infiltrated by numerous abnormal and heterogeneous blood vessels, forming a unique chaotic and irregular vascula...
Obesity and melanoma: unraveling the paradoxical survival benefit in immunotherapy [0.03%]
肥胖与黑色素瘤：解开免疫治疗中矛盾的生存益处之谜
Junjie Yang,Qingqing Hu,Chunyu Xue
Junjie Yang
The incidence of melanoma has been steadily increasing worldwide, with metastatic disease accounting for a substantial proportion of melanoma-related deaths. Immune checkpoint inhibitors (ICIs) have revolutionized the treatment landscape fo...
Patient-derived complex organoids are a critical tool to understand and explore pediatric malignant brain tumors [0.03%]
患者来源的复杂类器官是理解并探索儿童恶性脑肿瘤的关键工具
Marlène Deschuyter,Sophie Martin,Chinar Salmanli et al.
Marlène Deschuyter et al.
Pediatric malignant brain tumors (PMBTs) remain among the most common and challenging cancers in children and adolescents, with current therapies often failing to deliver satisfactory outcomes. A major obstacle is their intrinsic and extrin...
CAR-T cell therapy for pediatric solid tumors: armored CAR-T cells and beyond [0.03%]
儿童实体瘤CAR-T细胞疗法：穿铠甲的CAR-T细胞及未来方向
Jeremy Wells,Ajay Gupta
Jeremy Wells
CAR-T cell therapy, which uses endogenous T cells engineered to target specific cancer antigens, is one of the most promising recent developments in the treatment of hematologic malignancies in both children and adults. CAR-T cells have sho...
Shaping death: how the microbiome regulates tumour cell demise and therapy response [0.03%]
塑造死亡：微生物组如何调节肿瘤细胞凋亡和治疗反应
Martina Raudenska,Jan Balvan,Eliska Zgarbova et al.
Martina Raudenska et al.
Cell death is a fundamental process that maintains tissue homeostasis and shapes the tumour microenvironment. Cancer cells often evade or reprogram cell death pathways, which leads to malignancy and therapy resistance. On the other hand, th...
Peritoneal carcinomatosis in metastatic Non-Small Cell Lung Cancer: review of the literature [0.03%]
晚期非小细胞肺癌腹膜转移癌的治疗：文献回顾
Fausto Meriggi,Sara Cherri,Diego Gavezzoli et al.
Fausto Meriggi et al.
Lung cancer has a remarkably high global incidence and ranks among the most frequent malignancies, with mortality rates placing it first worldwide. Although lung cancer typically metastasizes to the brain, bone, adrenal glands, and liver, t...
PD-L1 subpopulations of metastatic urothelial carcinoma demonstrate heterogeneity to chemotherapy: an integrated analysis of digitized trial results [0.03%]
程序设计语言1亚群的转移性尿路上皮癌显示对化疗具有异质性：综合分析数字化试验结果
Jie Zhou,Xun Jiang,Qing Liu et al.
Jie Zhou et al.
Efforts to translate advances in immunology into anti-cancer immunotherapies have progressed rapidly in recent years. Six antibodies acting on programmed death ligand 1 or programmed death 1 pathways were approved in 75 cancer indications b...
The impact of genomic ancestry on tumor genomics in head and neck squamous cell carcinoma [0.03%]
基因组血统对头颈部鳞状细胞癌肿瘤基因组的影响
Madeleine Ndahayo,Anirudh Saxena,Hannah Thomas et al.
Madeleine Ndahayo et al.
Head and neck squamous cell carcinoma (HNSCC) exhibits significant survival disparities by ancestry. This review explores how genetic ancestry shapes the clinical and molecular features of HNSCC, providing insights into the molecular mechan...
Aprepitant increases the antitumor activity of chemotherapy by chemosensitizing breast cancer cells [0.03%]
阿普瑞坦通过使乳腺癌细胞对化疗敏感来增强化疗的抗肿瘤活性
Prema Robinson,Marisa Rosso,Yousef Zamil et al.
Prema Robinson et al.
Engineered bone matrix models for understanding breast cancer skeletal metastasis [0.03%]
用于理解乳腺癌骨转移的工程化骨基质模型
Kylie M Persson,Matthew A Whitman,Claudia Fischbach
Kylie M Persson
Bone is the most common site of metastasis in patients with advanced breast cancer and serves as a reservoir from which secondary metastases often originate. While research has traditionally focused on understanding the biochemical signals ...