Pexidartinib: Current advances in the symptomatic treatment of tenosynovial giant cell tumors [0.03%]
佩西达汀尼治疗滑膜巨细胞瘤的症状性发作的最新进展
Yulin Yuan,Zhuoer Zhang,Yanfeng Jiang et al.
Yulin Yuan et al.
Tenosynovial giant cell tumors (TGCTs), a rare benign mesenchymal neoplasm of synovial tissue, often incurs chronic pain, joint destruction and repeated surgery, markedly impairing quality of life. Historically, surgery was the only effecti...
Mahdi Hejazi Laein,Yazhini Thinakaran,Maryam Katoueezadeh et al.
Mahdi Hejazi Laein et al.
Cancer-derived extracellular vesicles (EVs), particularly exosomes, transfer oncogenic proteins, metabolites and nucleic acids to both nearby and distant cells. These diverse bioactive molecules act synergistically to promote cancer progres...
Measurable residual disease testing in acute myeloid leukemia: current state, foundational models, and tools for future development [0.03%]
急性髓系白血病中可测量残留疾病检测的现状、基础模型及未来发展的工具
Joseph Van Galen,Stephen D Willis,Ashish Bains et al.
Joseph Van Galen et al.
Acute myeloid leukemia (AML) is a lethal and rapidly progressive hematologic malignancy with high rates of relapse and treatment refractoriness. Management of AML is complicated by biological heterogeneity in a disease that is broadly defin...
The role of Notch signalling and its crosstalk with oestrogen receptor signalling in breast cancer [0.03%]
诺特金信号及其与雌激素受体信号串话在乳腺癌中的作用
Aygun Azadova,Orkhan Isayev,Antonio Marco et al.
Aygun Azadova et al.
Breast cancer (BCa) is the most frequently diagnosed malignancy in women worldwide, with approximately 70% of cases driven by oestrogen receptor alpha (ERα). Endocrine therapies aim to suppress ERα signalling activity and form the foundat...
From stress to strength: mechanotransducing poly(aneu)ploidy into a community-level advantage in cancer [0.03%]
从压力到力量：在癌症中将机械转导的多倍体转化为群体水平的优势
Víctor Herrera-Fernández,Paul Dremsek,Markus Hengstschläger et al.
Víctor Herrera-Fernández et al.
Poly(aneu)ploidy is a potent source of cellular stress that typically leads to loss of fitness, premature aging/senescence, and cell death. Yet in some systems, most notably microbial pathogens and human cancer cells under poly(aneu)ploidog...
Xueshiyu Ma,Peixuan Ji,Jiahao Zheng et al.
Xueshiyu Ma et al.
The nervous system is now recognized as a pivotal regulator of cancer, marking a paradigm shift that recasts nerves from passive bystanders to active drivers within the tumor microenvironment (TME). This review defines the "neural niche," d...
Hyponatremia in cancer patients receiving immune checkpoint inhibitors: the ARON-MOUSEION-014 meta-analysis [0.03%]
免疫检查点抑制剂治疗癌症患者的低钠血症：ARON-MOUSAIION-014荟萃分析
Elsa Vitale,Lorenza Maistrello,Francesco Ciccimarra et al.
Elsa Vitale et al.
Hyponatremia is the most prevalent electrolyte imbalance in cancer patients. Symptoms potentially signaling hyponatremia include altered mental status, neurological condition, headache, nausea, dizziness, and balance loss. Its management is...
Holly Holliday,Rebecca C Poulos
Holly Holliday
Metabolic dependencies and neural progenitor dysregulation: driving forces in paediatric high-grade glioma development [0.03%]
代谢依赖和神经前体失调：儿童高级别胶质瘤发展的驱动因素
Yan Hay Grace Lee,Maria Tsoli,Yan Chuan Shi et al.
Yan Hay Grace Lee et al.
Paediatric high-grade gliomas (pHGGs) are the most lethal brain tumours in children, characterised by profound epigenetic dysregulation and limited treatment options. The 2021 WHO Classification has established a molecular framework that di...
Early cellular plasticity promotes progression and dissemination in pancreatic adenocarcinoma [0.03%]
早期细胞多能性促进胰腺癌进展和转移
Giulio Innamorati,Giorgio Malpeli,Luca Giacomello et al.
Giulio Innamorati et al.
Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal malignancies, with limited therapeutic success and a persistently low 5-year survival rate. Despite significant advances in genomics and tumor biology, a fundamental cha...