Small cell lung cancer with liver metastases: from underlying mechanisms to treatment strategies [0.03%]
小细胞肺癌肝转移：从发病机制到治疗策略
Linjie Fan,Yiwen Lin,Yunjie Fu et al.
Linjie Fan et al.
Small cell lung cancer (SCLC) represents an aggressive neuroendocrine (NE) tumor within the pulmonary region, characterized by very poor prognoses. Druggable targets for SCLC remain limited, thereby constraining treatment options available ...
Yibo Xi,Lei Yang,Barbara Burtness et al.
Yibo Xi et al.
Tumor metastasis is the primary cause of cancer-related mortality and remains a major hurdle in cancer treatment. Traditional cigarette smoking has been extensively studied for its role in promoting metastasis. However, the impact of e-ciga...
KIF18A inhibition: the next big player in the search for cancer therapeutics [0.03%]
KIF18A抑制：在癌症治疗研究中下一个重要的角色
Ain Syafiza Mohd Amin,Sarah Eastwood,Courtney Pilcher et al.
Ain Syafiza Mohd Amin et al.
Kinesin-like protein 18A (KIF18A) is a member of the kinesin family of molecular motor proteins, which utilise energy from the hydrolysis of adenosine triphosphate (ATP) to regulate critical cellular processes such as chromosome movement an...
A possible role of plasmin-dependent activation of TGF-β in cancer-associated thrombosis: Implications for therapy [0.03%]
纤溶酶依赖性转化生长因子-β活化在癌症相关血栓形成中可能的作用及治疗意义
Marta Smeda,Ebrahim H Maleki,Agnieszka Jasztal
Marta Smeda
While the prevalence of cancer-associated thrombosis (CAT) is high in cancer patients, its molecular mechanisms have not been fully elucidated. Moreover, the risks of recurrent CAT events and mortality remain high in cancer patients despite...
Bystanders or active players: the role of extra centrosomes as signaling hubs [0.03%]
旁观者还是积极的参与者：作为信号中心的额外中心体的作用
Madison M Purkerson,Sarah R Amend,Kenneth J Pienta
Madison M Purkerson
Centrosomes serve as microtubule-organizing organelles that function in spindle pole organization, cell cycle progression, and cilia formation. A non-canonical role of centrosomes that has gained traction in recent years is the ability to a...
Tumor necrosis factor superfamily signaling: life and death in cancer [0.03%]
肿瘤坏死因子超家族信号通路在癌症中的生死作用
Obada Ababneh,Daisuke Nishizaki,Shumei Kato et al.
Obada Ababneh et al.
Immune checkpoint inhibitors have shaped the landscape of cancer treatment. However, many patients either do not respond or suffer from later progression. Numerous proteins can control immune system activity, including multiple tumor necros...
Mitochondrial ribosomal proteins in metastasis and their potential use as prognostic and therapeutic targets [0.03%]
线粒体核糖体蛋白在转移中的作用及其作为预后和治疗靶点的潜力
Jasmine M Bacon,Johanna L Jones,Guei-Sheung Liu et al.
Jasmine M Bacon et al.
The mitochondrion is an essential cell organelle known as the powerhouse of the cell. Mitochondrial ribosomal proteins (MRPs) are nuclear encoded, synthesised in the cytoplasm but perform their main functions in the mitochondria, which incl...
Functional links between the microbiome and the molecular pathways of colorectal carcinogenesis [0.03%]
肠道微 biome与结直肠癌发生发展分子通路的相互作用关系
Jessica Permain,Barry Hock,Timothy Eglinton et al.
Jessica Permain et al.
Colorectal cancer (CRC) is a common cancer, with a concerning rise in early-onset CRC cases, signalling a shift in disease epidemiology. Whilst our understanding of the molecular underpinnings of CRC has expanded, the complexities underlyin...
Tina Trautmann,Natalia Yakobian,Rosa Nguyen
Tina Trautmann
Despite the great success that chimeric antigen receptor (CAR) T-cells have had in patients with B-cell malignancies and multiple myeloma, they continue to have limited efficacy against most solid tumors. Especially in the pediatric populat...
CAR T cells in solid tumors and metastasis: paving the way forward [0.03%]
CAR-T细胞在实体瘤和转移瘤中的应用：展望未来之路
Camilla Sirini,Laura De Rossi,Marta Angiola Moresco et al.
Camilla Sirini et al.
CAR T cell therapy, hailed as a breakthrough in cancer treatment due to its remarkable outcomes in hematological malignancies, encounters significant hurdles when applied to solid tumors. While notable responses to CAR T cells remain sporad...