Correlative studies reveal factors contributing to successful CAR-T cell therapies in cancer [0.03%]
相关研究揭示了癌症CAR-T细胞治疗成功的因素
Catherine D Yao,Kara L Davis
Catherine D Yao
Cellular and targeted immunotherapies have revolutionized cancer treatments in the last several decades. Successful cellular therapies require both effective and durable cytotoxic activity from the immune cells as well as an accessible and ...
CAR T-cell therapy to treat multiple myeloma: current state and future directions [0.03%]
治疗多发性骨髓瘤的CAR-T细胞疗法：现状与未来方向
Siddhartha Thammineni Reddy,Hitomi Hosoya,Lekha Mikkilineni
Siddhartha Thammineni Reddy
Chimeric antigen receptor (CAR) T-cell therapy represents a transformative advancement in treating relapsed or refractory multiple myeloma (MM) in both early- and late-line settings. MM, a plasma cell malignancy, traditionally requires ongo...
Ribosomal rodeo: wrangling translational machinery in gynecologic tumors [0.03%]
核糖体骑术：妇科肿瘤中翻译机制的研究挑战与策略
Kamil Filipek,Marianna Penzo
Kamil Filipek
Gynecologic cancers are a significant cause of morbidity and mortality among women worldwide. Despite advancements in diagnosis and treatment, the molecular mechanisms underlying the development and progression of these cancers remain poorl...
CAR T-cell therapy for B-cell lymphomas: outcomes and resistance mechanisms [0.03%]
针对B细胞淋巴瘤的CAR-T细胞治疗：疗效及耐药机制
Tyce J Kearl,Fateeha Furqan,Nirav N Shah
Tyce J Kearl
Chimeric antigen receptor (CAR) T cells are an exciting curative intent approach to the treatment of non-Hodgkin lymphomas (NHLs). Several products have received FDA approval for 2nd or 3rd line indications, and studies are underway for the...
The roles of periostin derived from cancer-associated fibroblasts in tumor progression and treatment response [0.03%]
肿瘤相关成纤维细胞源性periostin在肿瘤进展及治疗反应中的作用
Yasmin De Oliveira Macena,Maria Eduarda Nunes Cezar,Cinthya Brunelly Ferreira Lira et al.
Yasmin De Oliveira Macena et al.
Periostin (POSTN), a matricellular protein predominantly secreted by cancer-associated fibroblasts (CAFs), has emerged as a key regulator of cancer progression and therapy response. This review provides an overview of recent findings regard...
Immunotherapy for leptomeningeal disease from solid tumors: current clinical outcomes and future opportunities [0.03%]
实体瘤所致脑膜转移癌的免疫治疗：目前临床疗效和未来前景
Eleanor C Smith,Bryan T Mott,Emily Douglas et al.
Eleanor C Smith et al.
Leptomeningeal disease is a debilitating, late-stage form of metastatic cancer disseminated within the cerebrospinal fluid, subarachnoid space, and leptomeninges, leading to significant neurological morbidity and mortality. As systemic canc...
Melanoma in people living with HIV: Immune landscape dynamics and the role of immuno- and antiviral therapies [0.03%]
人类免疫缺陷病毒感染者黑色素瘤的免疫景观及免疫和抗病毒治疗的作用
Lindsay N Barger,Olivia S El Naggar,Binh Ha et al.
Lindsay N Barger et al.
The intersection of HIV and melanoma presents a complex and unique challenge, marked by distinct patterns in incidence, mortality, and treatment response. Higher mortality rates among people with HIV who develop melanoma underscore an urgen...
Tissue-engineered patient-derived osteosarcoma models dissecting tumour-bone interactions [0.03%]
基于组织工程的患者衍生骨肉瘤模型解析肿瘤-骨骼相互作用
Tina Frankenbach-Désor,Isabella Niesner,Parveen Ahmed et al.
Tina Frankenbach-Désor et al.
Osteosarcoma is the most common malignant bone tumor, primarily affecting children and young adults. For these young patients, the current treatment options for osteosarcoma impose considerable constraints on daily life with significant mor...
Dipak Panigrahy,Emily R Greene,Ambra Pozzi et al.
Dipak Panigrahy et al.
Retraction of Publication
Cancer metastasis reviews. 2024 Nov 26;44(1):7. DOI:10.1007/s10555-024-10229-z 2024
Cell-cell interactions mediating primary and metastatic breast cancer dormancy [0.03%]
调控乳腺癌休眠的细胞间相互作用
Nicholas A Lenart,Shreyas S Rao
Nicholas A Lenart
Breast cancer remains one of the leading causes of death in women around the world. A majority of deaths from breast cancer occur due to cancer cells colonizing distant organ sites. When colonizing these distant organ sites, breast cancer c...