Sympathetic nerve signaling rewires the tumor microenvironment: a shift in "microenvironmental-ity" [0.03%]
交感神经信号改变肿瘤微环境：微环境的转变
Ariana Sattler,Tetiana Korzun,Kasmira Gupta et al.
Ariana Sattler et al.
Nerve signaling within the tumor microenvironment (TME) plays a critical role in the initiation, progression, and metastasis of solid tumors. Due to their highly responsive behavior and activation upon injury and cancer onset, this review s...
LGR5: An emerging therapeutic target for cancer metastasis and chemotherapy resistance [0.03%]
LGR5：癌症转移和化疗耐药的新治疗靶点
Wanqi Wang,Noor A Lokman,Simon C Barry et al.
Wanqi Wang et al.
Cancer stem cells play an important role in tumor progression and chemotherapy resistance. Leucine-rich G repeat-containing protein-coupled receptor 5 (LGR5) has been identified as a cancer stem cell marker in several cancer types. LGR5 is ...
Yuhang Wang,Thuy Anh Bui,Xinpu Yang et al.
Yuhang Wang et al.
Mutations in the KRAS gene are well-known tumourigenic drivers of colorectal, pancreatic and lung cancers. Mechanistically, these mutations promote uncontrolled cell proliferation and alter the tumour microenvironment during early carcinoma...
Stefan Koch
Stefan Koch
FOXQ1 is a member of the large forkhead box (FOX) family of transcription factors that is involved in all aspects of mammalian development, physiology, and pathobiology. FOXQ1 has emerged as a major regulator of epithelial-to-mesenchymal tr...
Neuropeptide Y in cancer-biological functions and potential clinical implications [0.03%]
神经肽Y与癌症-生物学功能及潜在临床意义
Dawid Sigorski,Aleksandra Sejda,Nouran Abualsaud et al.
Dawid Sigorski et al.
Neuropeptide Y (NPY) is a sympathetic neurotransmitter widely distributed in the peripheral and central nervous system, affecting many physiological functions. Consequently, dysregulation of the NPY system contributes to numerous pathologic...
Recapitulating the potential contribution of protein S-palmitoylation in cancer [0.03%]
蛋白质S-棕榈酰化在癌症中的潜在作用综述
Suchi Chaturvedi,Avinash Sonawane
Suchi Chaturvedi
Protein S-palmitoylation is a reversible form of protein lipidation in which the formation of a thioester bond occurs between a cysteine (Cys) residue of a protein and a 16-carbon fatty acid chain. This modification is catalyzed by a family...
Homologous recombination deficiency (HRD) diagnostics: underlying mechanisms and new perspectives [0.03%]
同源重组缺陷(HRD)的诊断：潜在机制和新视角
Andrey Kechin,Maksim Koryukov,Regina Mikheeva et al.
Andrey Kechin et al.
Homologous recombination deficiency (HRD) is considered a universal and effective sign of a tumor's sensitivity to poly(ADP-ribose) polymerase (PARP) inhibitors. HRD diagnostics have undergone several stages of transformations: from detecti...
Influence of antibody-drug conjugate cleavability, drug-to-antibody ratio, and free payload concentration on systemic toxicities: A systematic review and meta-analysis [0.03%]
抗体药物偶联物的释放特性、药物与抗体比率和自由载荷浓度对全身毒性的影响：系统评价和meta分析
Shou-Ching Tang,Carrie Wynn,Tran Le et al.
Shou-Ching Tang et al.
While in theory antibody drug conjugates (ADCs) deliver high-dose chemotherapy directly to target cells, numerous side effects are observed in clinical practice. We sought to determine the effect of linker design (cleavable versus non-cleav...
Alexander W Rankin,Brynn B Duncan,Cecily Allen et al.
Alexander W Rankin et al.
The field of chimeric antigen receptor (CAR) T-cell therapy has grown from a fully experimental concept to now boasting a multitude of treatments including six FDA-approved products targeting various hematologic malignancies. Yet, along wit...
TRIM-endous functional network of tripartite motif 29 (TRIM29) in cancer progression and beyond [0.03%]
三聚体 motif 29 (TRIM29) 在癌症进展中的功能网络研究及其应用展望
Qitong Wu,Deeptashree Nandi,Dipali Sharma
Qitong Wu
While most Tripartite motif (TRIM) family proteins are E3 ubiquitin ligases, some members have functions beyond the regulation of ubiquitination, impacting normal physiological processes and disease progression. TRIM29, an important member ...