Tsung-Hsien Chen,Shu-Hsien Lin,Ming-Yang Lee et al.
Tsung-Hsien Chen et al.
Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer worldwide. Its primary risk factors are chronic liver diseases such as metabolic fatty liver disease, non-alcoholic steatohepatitis, and hepatitis B and C viral ...
p62/SQSTM1 in cancer: phenomena, mechanisms, and regulation in DNA damage repair [0.03%]
癌症中的p62 / SQSTM1：DNA损伤修复的现象，机制和调控
Xiaojuan Yang,Xunjie Cao,Qing Zhu
Xiaojuan Yang
The multidomain protein cargo adaptor p62, also known as sequestosome 1, serves as a shuttling factor and adaptor for the degradation of substrates via the proteasome and autophagy pathways. Regarding its structure, p62 is composed of sever...
CTGF (CCN2): a multifaceted mediator in breast cancer progression and therapeutic targeting [0.03%]
CTGF（CCN2）：在乳腺癌进展和治疗靶向中的多面介质
Priya Ghosh,Ankita Dey,Suvendu Nandi et al.
Priya Ghosh et al.
Breast cancer, with its diverse subtypes like ER-positive, HER-2-positive, and triple-negative, presents complex challenges demanding personalized treatment approaches. The intricate interplay of genetic, environmental, and lifestyle factor...
Neuronal mimicry in tumors: lessons from neuroscience to tackle cancer [0.03%]
肿瘤的神经元模拟：从神经科学中吸取教训以应对癌症
Hanan Bloomer,Haley B Dame,Savannah R Parker et al.
Hanan Bloomer et al.
Cellular plasticity and the ability to avoid terminal differentiation are hallmarks of cancer. Here, we review the evidence that tumor cells themselves can take on properties of neurons of the central nervous system, which can regulate tumo...
Immunomodulatory role of oncogenic alterations in non-small cell lung cancer: a review of implications for immunotherapy [0.03%]
驱动基因变异的免疫调变作用及其非小细胞肺癌免疫治疗意义再思考
Maritza Ramos-Ramírez,Enrique Caballe-Pérez,José Lucio-Lozada et al.
Maritza Ramos-Ramírez et al.
Immune checkpoint inhibitors (ICIs) have improved clinical outcomes in patients with non-small cell lung cancer (NSCLC) lacking targetable oncogenic alterations. However, their efficacy in individuals with such genomic alterations remains h...
Efficacy of innovative systemic treatments in combination with radiotherapy for bone metastases: a GEMO (the European Study Group of Bone Metastases) state of the art [0.03%]
创新性系统治疗与放射治疗联合治疗骨转移瘤的疗效：欧洲骨转移瘤研究组现状分析
Anna Gueiderikh,Jean-Christophe Faivre,Constance Golfier et al.
Anna Gueiderikh et al.
The management of bone metastases (BoM) requires a multidisciplinary approach to prevent complications, necessitating updated knowledge in light of the rapid advancements in systemic treatments and surgical, interventional radiology or radi...
Cellular plasticity and non-small cell lung cancer: role of T and NK cell immune evasion and acquisition of resistance to immunotherapies [0.03%]
肿瘤细胞的免疫逃逸和获得性免疫治疗抵抗与肺癌细胞的可塑性密切相关
Sarra Mestiri,Ana Sami,Naresh Sah et al.
Sarra Mestiri et al.
Lung cancer is a leading global cause of mortality, with non-small cell lung cancer (NSCLC) accounting for a significant portion of cases. Immune checkpoint inhibitors (ICIs) have transformed NSCLC treatment; however, many patients remain u...
The diversity of natural killer cell functional and phenotypic states in cancer [0.03%]
癌症中天然杀伤细胞功能和表型状态的多样性
Kumar Rishabh,Sandro Matosevic
Kumar Rishabh
The role of natural killer (NK) cells as immune effectors is well established, as is their utility as immunotherapeutic agents against various cancers. However, NK cells' anti-cancer roles are suppressed in cancer patients by various immuno...
Sympathetic nerve signaling rewires the tumor microenvironment: a shift in "microenvironmental-ity" [0.03%]
交感神经信号改变肿瘤微环境：微环境的转变
Ariana Sattler,Tetiana Korzun,Kasmira Gupta et al.
Ariana Sattler et al.
Nerve signaling within the tumor microenvironment (TME) plays a critical role in the initiation, progression, and metastasis of solid tumors. Due to their highly responsive behavior and activation upon injury and cancer onset, this review s...
LGR5: An emerging therapeutic target for cancer metastasis and chemotherapy resistance [0.03%]
LGR5：癌症转移和化疗耐药的新治疗靶点
Wanqi Wang,Noor A Lokman,Simon C Barry et al.
Wanqi Wang et al.
Cancer stem cells play an important role in tumor progression and chemotherapy resistance. Leucine-rich G repeat-containing protein-coupled receptor 5 (LGR5) has been identified as a cancer stem cell marker in several cancer types. LGR5 is ...