The role of liver sinusoidal endothelial cells in metabolic dysfunction-associated steatotic liver diseases and liver cancer: mechanisms and potential therapies [0.03%]
肝窦内皮细胞在代谢功能障碍相关性脂肪性肝病和肝癌中的作用：机制及潜在治疗策略
Hanjun Mo,Pengfei Yue,Qiaoqi Li et al.
Hanjun Mo et al.
Liver sinusoidal endothelial cells (LSECs), with their unique morphology and function, have garnered increasing attention in chronic liver disease research. This review summarizes the critical roles of LSECs under physiological conditions a...
Clioquinol inhibits angiogenesis by promoting VEGFR2 degradation and synergizes with AKT inhibition to suppress triple-negative breast cancer vascularization [0.03%]
克利奥quine通过促进VEGFR2降解来抑制血管生成，并与AKT抑制剂协同作用以抑制三阴性乳腺癌的血管化
Yuan Gu,Tianci Tang,Moqin Qiu et al.
Yuan Gu et al.
Inhibition of angiogenesis, either as monotherapy or in conjunction with other treatments, holds significant promise in cancer treatment. However, the limited efficacy of clinically approved anti-angiogenic agents underscores the urgent nee...
Marissa J Harmsen,Lynda J M Juffermans,Muara O Kroon et al.
Marissa J Harmsen et al.
Adenomyosis is characterized by abnormal uterine bleeding, dysmenorrhea and subfertility. Increased expression of angiogenesis markers in adenomyosis presents a treatment opportunity and was studied in an adenomyosis mouse model. Mice were ...
Ref-1 is overexpressed in neovascular eye disease and targetable with a novel inhibitor [0.03%]
REF-1在新生血管性眼病中过度表达且可被新型抑制剂靶向作用
Anbukkarasi Muniyandi,Gabriella D Hartman,Kamakshi Sishtla et al.
Anbukkarasi Muniyandi et al.
Reduction-oxidation factor-1 or apurinic/apyrimidinic endonuclease 1 (Ref-1/APE1) is a crucial redox-sensitive activator of transcription factors such as NF-κB, HIF-1α, STAT-3 and others. It could contribute to key features of ocular neov...
A novel quantitative angiogenesis assay based on visualized vascular organoid [0.03%]
一种基于可视化血管小体的新型定量血管生成检测方法
Yun Zhao,Mengze Sun,Zihang Pan et al.
Yun Zhao et al.
Angiogenesis describes the sprouting of blood vessels from existing vasculatures and it plays a pivotal role in disease progress such as diabetes, age-related macular degeneration and cancer. However, the most widely used anti-angiogenic ag...
Effect of oral nintedanib vs placebo on epistaxis in hereditary hemorrhagic telangiectasia: the EPICURE multicenter randomized double-blind trial [0.03%]
口服尼替尼与安慰剂对遗传性出血性毛细血管扩张症鼻出血的影响：EPICURE 多中心随机双盲试验
Ruben Hermann,Vincent Grobost,Xavier Le-Guillou et al.
Ruben Hermann et al.
Epistaxis greatly affects patients with hereditary hemorrhagic telangiectasia (HHT). Although few systemic treatment exist, nintedanib, is a good candidate thanks to its anti-angiogenic activity. Our main objective was to evaluate the effic...
Clinical Trial
Angiogenesis. 2024 Dec 24;28(1):9. DOI:10.1007/s10456-024-09962-4 2024
Circulating endothelial cells: a key biomarker of persistent fatigue after hospitalization for COVID-19 [0.03%]
新冠病毒住院治疗后的持续疲劳与循环内皮细胞这一关键生物标志物有关
David M Smadja,Sven Günther,Pauline Cavagna et al.
David M Smadja et al.
Neuropilin-1 controls vascular permeability through juxtacrine regulation of endothelial adherens junctions [0.03%]
神经纤毛蛋白1通过相邻调节内皮细胞粘着带控制血管通透性
Sagnik Pal,Yangyang Su,Emmanuel Nwadozi et al.
Sagnik Pal et al.
Neuropilin-1 (NRP1) regulates endothelial cell (EC) biology through modulation of vascular endothelial growth factor receptor 2 (VEGFR2) signalling by presenting VEGFA to VEGFR2. How NRP1 impacts VEGFA-mediated vascular hyperpermeability ha...
Genetic and pharmacological targeting of mTORC1 in mouse models of arteriovenous malformation expose non-cell autonomous signalling in HHT [0.03%]
利用小鼠遗传和药理模型针对动静脉畸形中的mTORC1靶向作用揭示HHT中非细胞自主性信号转导作用
Antonio Queiro-Palou,Yi Jin,Lars Jakobsson
Antonio Queiro-Palou
Arteriovenous malformations (AVMs) are abnormal high flow shunts between arteries and veins with major negative impact on the cardiovascular system. Inherited loss-of-function (LOF) mutations in endoglin, encoding an endothelial cell (EC) e...
Alk1/Endoglin signaling restricts vein cell size increases in response to hemodynamic cues [0.03%]
ALK1/ENDOGLIN信号限制血流动力学线索介导的静脉细胞体积增大反应
Zeenat Diwan,Jia Kang,Emma Tsztoo et al.
Zeenat Diwan et al.
Hemodynamic cues are thought to control blood vessel hierarchy through a shear stress set point, where flow increases lead to blood vessel diameter expansion, while decreases in blood flow cause blood vessel narrowing. Aberrations in blood ...