CXCL12/CXCR4 signaling governs ischemic neurovascular pathophysiology and repair: a multidimensional contextual analysis [0.03%]
CXCL12/CXCR4信号通路调控缺血性神经血管病理生理与修复：多维度分析研究进展
Shahram Eisa-Beygi,Hao Wu,Kui Cui et al.
Shahram Eisa-Beygi et al.
Ischemic stroke is a global health crisis necessitating targeted therapeutic strategies. Central to post-stroke pathology and repair is the CXCL12 signaling axis. In this review, we discuss the context-dependent roles of CXCL12 and its cano...
Pathogenesis and molecular mechanisms of mutant TIE2-driven venous malformation [0.03%]
突变TIE2驱动的静脉畸形的发病机制和分子机制
Lindsay J Bischoff,Elisa Boscolo
Lindsay J Bischoff
Venous malformation (VM) is the most common subtype of vascular malformation. Due to the chronic nature of this disorder, VM patients face significant morbidity and complications throughout their lives. Current therapeutic options can be li...
Antisense oligonucleotide-mediated disruption of mRNA localisation inhibits angiogenesis [0.03%]
反义寡核苷酸介导的mRNA定位干扰抑制血管生成
Josy Augustine,Precious O Owuamalam,Jennifer Nicell et al.
Josy Augustine et al.
mRNA localisation is a critical posttranscriptional mechanism that confers a spatiotemporal dimension to the control of gene expression. Among diverse outcomes, this process can result in compartmentalised protein synthesis and consequently...
Integrin inhibition differentially remodels vascular networks in lung metastases driven by vessel co-option or angiogenesis [0.03%]
整合素抑制剂通过不同机制重塑肺转移灶血管网络
Laura Marcos-Zazo,Iván Carrera-Aguado,Jesús Gómez-Escudero et al.
Laura Marcos-Zazo et al.
Tumor progression depends on an adequate blood supply to sustain oxygen and nutrients delivery. While tumor angiogenesis involves the formation of new blood vessels from pre-existing ones, vessel co-option represents a non-angiogenic vascul...
Mohammad R Nikmaneshi,Lennard M Weide,Noel-Adrian Hollosi et al.
Mohammad R Nikmaneshi et al.
De novo vessel formation (vasculogenesis) in vitro is a key step in tissue engineering to preserve tissue viability for long-term assays and testing therapeutic agents. However, in vitro vasculogenesis is often unreliable due to differences...
Lysosomal channel TPC2 modulates microglia-endothelial signaling in choroidal angiogenesis [0.03%]
溶酶体通道TPC2在脉络膜新生血管微胶质细胞-内皮细胞信号转导中的作用
Yi Lu,Alice Reschigna,Franz Kynast et al.
Yi Lu et al.
Pathological choroidal neovascularization underlies vision loss in neovascular age-related macular degeneration (nAMD), yet the molecular regulators coordinating vascular and immune components remain incompletely defined. Here, we investiga...
Smad3 deficiency attenuates disease severity in a zebrafish model for Smad6-related aortic disease [0.03%]
SMAD3缺陷减轻斑马鱼SMAD6相关主动脉疾病模型的病情严重程度
Michiel Vanhooydonck,Maxim Verlee,Marta Santana Silva et al.
Michiel Vanhooydonck et al.
Thoracic aortic dissection (TAD) associates with a high mortality rate. Treatment options are limited and mainly consist of surgical repair at critical aortic diameters as current pharmacological interventions are unable to stop disease pro...
Long-term angiogenic and thromboinflammatory signatures in post-COVID-19 syndrome [0.03%]
“长期血管生成和血栓炎性印记在新冠后遗症中的作用”
Arlette Araceli Mora Zetina,Erika Fabiola Ortega Sanchez,Brenda Saraí Zuñiga Ascencio et al.
Arlette Araceli Mora Zetina et al.
Background: Post-COVID-19 syndrome is a major long-term sequela of severe SARS-CoV-2 infection, potentially involving persistent angiogenic and thromboinflammatory dysfunction, though long-term biomarker behavior remains ...
3D co-culture model of tumor spheroid and endothelial cells unveils ccRCC aberrant vasculature and distinct sensitivity to targeted treatments [0.03%]
三维共培养模型揭示透明细胞肾细胞癌异常血管生成及对靶向治疗的不同敏感性
Noémie Brassard-Jollive,Yoann Atlas,Camille L M Compère et al.
Noémie Brassard-Jollive et al.
Clear cell renal cell carcinoma (ccRCC), the most common renal cancer, is largely driven by von Hippel Lindau (VHL) protein deficiency. VHL inactivation promotes epithelial-to-mesenchymal transition (EMT), invasion, and hypervascularization...
Functional definition of endothelial progenitors by PROCR and PDGFRA co-expression [0.03%]
PROCR和PDGFRA共表达的功能性内皮前体定义
Cassandra Styke,Simranpreet Kaur,Seen-Ling Sim et al.
Cassandra Styke et al.
The functional and molecular definition of progenitors giving rise to blood vessel endothelium in vivo remains disputed. Upon investigating the overlap of seemingly divergent reports currently defining putative endothelial progenitor cells ...