Functional definition of endothelial progenitors by PROCR and PDGFRA co-expression [0.03%]
PROCR和PDGFRA共表达的功能性内皮前体定义
Cassandra Styke,Simranpreet Kaur,Seen-Ling Sim et al.
Cassandra Styke et al.
The functional and molecular definition of progenitors giving rise to blood vessel endothelium in vivo remains disputed. Upon investigating the overlap of seemingly divergent reports currently defining putative endothelial progenitor cells ...
Semi-automated quantification of total and avascular retinal area in the rat model of oxygen-induced retinopathy [0.03%]
氧诱导视网膜病变大鼠模型视网膜总面积和无血管区面积的半自动量化方法
Husaam Qureishy,Amelia Morikuni,Michael D Evans et al.
Husaam Qureishy et al.
Quantification of retinal and avascular areas in the rat oxygen induced retinopathy (OIR) model is traditionally performed using time-intensive manual methods that may be subject to inter-rater variability. We developed and validated two op...
Critical role of endothelial regulator of G protein signaling 5 in postnatal angiogenesis [0.03%]
内皮细胞G蛋白信号调节素5在出生后新生血管生成中的关键作用
Nikola Sladojevic,Haw-Chih Tai,Dhiraj Patel et al.
Nikola Sladojevic et al.
Aims: Regulator of G protein signaling 5 (RGS5) modulates G-protein coupled receptor (GPCR) signaling and is markedly upregulated in angiogenesis. However, its function in endothelial cells and its role in mediating postn...
Endothelial VEGFR2 insufficiency promotes the transition of lymphatic to hematopoietic transcriptional programs [0.03%]
内皮VEGFR2不足促进淋巴转录程序向血液转录程序的转变
Taotao Li,Xudong Cao,Fei Zhou et al.
Taotao Li et al.
Vascular endothelial growth factor receptor-2 (VEGFR2) is a key target for regulating the endothelial cell lineage and angiogenesis. It is also expressed by lymphatic endothelial cells (LECs) while its participation in lymphangiogenesis rem...
Endothelial Notch1 drives multicellular remodelling during hyaloid vessel regression [0.03%]
内皮Notch1在透明血管退化过程中驱动多细胞重塑
Shaymaa Khazaal,Abdoul-Razak Sango,Kawtar Zouine et al.
Shaymaa Khazaal et al.
Hyaloid vessel regression is essential for vitreous transparency and normal vision, yet how this transient vascular network is dismantled remains unclear. Here we show that postnatal hyaloid regression in mice is not driven by a measurable ...
Tumour endothelial cell reprogramming orchestrates angiocrine signalling to drive chemoresistance in breast cancer [0.03%]
肿瘤内皮细胞重编程协调化学抗性乳腺癌的血管内分泌信号转导
Jesus Gomez-Escudero,Eleni Maniati,Julie Holdsworth et al.
Jesus Gomez-Escudero et al.
Despite its established role in breast cancer treatment, Doxorubicin treatment remains subject to adaptive resistance mechanisms that extend beyond cancer cell intrinsic alterations ultimately reducing therapy efficacy. Our study in a MMTV-...
A possible microvascular vulnerability in carotid artery dissection: insights from nailfold capillaroscopy [0.03%]
颈内动脉夹层可能的微血管易损性：来自甲襞 капилляроскопии的见解
Angelo Nigro,Sandro Sanguigni,Giuseppe Nicoletti
Angelo Nigro
miR-150 controls developmental angiogenesis via ribosome biogenesis-dependent regulation of Notch signaling [0.03%]
微RNA-150通过调控核糖体生物发生依赖性的诺特定理信号控制发育血管生成
Haotian Kong,Kang Ai,Jinghe Zhang et al.
Haotian Kong et al.
The development of a functional vasculature is controlled by the coordination of various mechanisms. Key molecules and signaling pathways regulating vascular development remain far from understood. Here, we demonstrate that miR-150 is highl...
MCC links Wnt/PCP signaling to endothelial polarity and vascular remodeling [0.03%]
MCC连接Wnt/PCP信号转导至内皮细胞极性和血管重塑
Valentin Delobel,Béatrice Jaspard,Malvina Salami et al.
Valentin Delobel et al.
Vascular remodeling is crucial for establishing a functional vasculature and maintaining organ homeostasis. In the central nervous system (CNS), Wnt signaling plays a critical role in guiding endothelial cell (EC) behavior during vascular d...