Diversity of extracellular vesicle sources in atherosclerosis: role and therapeutic application [0.03%]
动脉粥样硬化中细胞外囊泡来源的多样性：作用及治疗应用
Yuan Zhang,Wendiao Zhang,Zhiwen Wu et al.
Yuan Zhang et al.
Extracellular vesicles (EVs) are phospholipid bilayer membrane structures secreted by cells and widely present in blood or body fluids, playing critical roles in cell communication and homeostasis. Increasing evidence has implicated EVs dys...
An endothelial specific mouse model for the capillary malformation mutation Gnaq p.R183Q [0.03%]
GNAQ p.R183Q毛细血管畸形小鼠模型的内皮特异性表达
Patrick Smits,Leanna Marrs,Yu Sheng Cheng et al.
Patrick Smits et al.
Capillary malformation (CM) is a congenital, non-hereditary lesion composed of enlarged and tortuous blood vessels. CM is associated with a somatic p.R183Q activating mutation in the Guanine nucleotide-binding protein G(q) subunit alpha (GN...
High-throughput differentiation of human blood vessel organoids reveals overlapping and distinct functions of the cerebral cavernous malformation proteins [0.03%]
高通量分化人类血管器官样结构揭示脑海绵状畸形蛋白的重叠和独特功能
Dariush Skowronek,Robin A Pilz,Valeriia V Saenko et al.
Dariush Skowronek et al.
Cerebral cavernous malformations (CCMs) are clusters of thin-walled enlarged blood vessels in the central nervous system that are prone to recurrent hemorrhage and can occur in both sporadic and familial forms. The familial form results fro...
Polysialic acid regulates glomerular microvasculature formation by interaction with VEGF-A188 in mice [0.03%]
多唾液酸调节小鼠肾小球微血管形成及其与VEGF-A188的相互作用
Kristina M Niculovic,Manuel M Vicente,Vanessa Wittek et al.
Kristina M Niculovic et al.
Vascular endothelial growth factor A (VEGF-A) is a key signalling protein that stimulates blood vessel development and repair. Its tight control is essential for organ development and tissue homeostasis. However, the complex regulatory netw...
Human endothelial colony forming cells (ECFCs) require endothelial protein C receptor (EPCR) for cell cycle progression and angiogenic activity [0.03%]
人内皮基质形成细胞(ECFC)需要内皮型蛋白C受体(EPCR)来促进细胞周期进程和血管生成活性
Sarah E J Chambers,Jasenka Guduric-Fuchs,Edoardo Pedrini et al.
Sarah E J Chambers et al.
Vascular repair and regeneration are critical for tissue homeostasis. Endothelial colony forming cells (ECFCs) are vessel-resident progenitors with vasoreparative capacity and they offer an important avenue for allogeneic cytotherapy to ach...
Tinghong Zhang,Binqiang Zhu,Shijie Deng et al.
Tinghong Zhang et al.
Stromal cell-derived factor-1 alpha (SDF-1α) is a promising target for therapeutic angiogenesis in ischemic diseases such as peripheral artery disease (PAD). However, the clinical application of SDF-1α protein or plasmid-based gene therap...
Acute aortic dissection in a patient with Hereditary Hemorrhagic Telangiectasia associated with Juvenile Polyposis due to SMAD4 mutation: case report and literature review [0.03%]
SMAD4突变所致遗传性出血性毛细血管扩张症伴幼年型息肉病患者的急性主动脉夹层：病例报告和文献复习
Catalina Pezzoto,Ana Braslavsky,Carolina Vázquez et al.
Catalina Pezzoto et al.
Objective: We present a novel case of concurrent Hereditary Hemorrhagic Telangiectasia-Juvenile Polyposis Syndrome (HHT-JP), resulting in a fatal aortic dissection. Given rarity of the case, we aimed to perform a comprehe...
Mixed lineage kinase (MLK) controls tumor development and angiogenesis [0.03%]
混合谱系激酶(MLK)调控肿瘤发生及新生血管形成
Shashi Kant,Amada D Caliz,Hyung-Jin Yoo et al.
Shashi Kant et al.
Cancer is among the leading causes of death in the USA and worldwide. Solid tumors require the formation of new blood vessels (angiogenesis) for their growth. The endothelium plays a crucial role in angiogenesis and tumor progression. Hypox...
The VEGF decoy receptor soluble Fms-like tyrosine kinase 1 binds to macrophages [0.03%]
VEGF欺骗受体可溶性Fms样酪氨酸激酶1与巨噬细胞结合
Cleo C L van Aanhold,Qing Yong,Lisa Landman et al.
Cleo C L van Aanhold et al.
Background: Soluble Fms-like Tyrosine kinase-1 (sFLT1) is a native inhibitor of VEGF, best known for its antiangiogenic effects in preeclampsia. sFLT1 also reduces chronic inflammation and promotes tissue repair. In exper...
G protein-coupled receptor GPR182 negatively regulates sprouting angiogenesis via modulating CXCL12-CXCR4 axis signaling [0.03%]
G蛋白偶联受体GPR182通过调节CXCL12-CXCR4轴信号负向调控血管生成毛细血管出芽
Changsheng Chen,Wei Liu,Fang Yuan et al.
Changsheng Chen et al.
Angiogenesis is a critical process for tumor progression, regulated by various signaling pathways. Although antiangiogenic therapies targeting the VEGF pathway have shown potential, their effectiveness is inconsistent across different tumor...