MY-1 promotes angiogenesis in the ischemic hindlimbs by regulating the stability of CDC42 via PSMD14 [0.03%]
MY-1通过PSMD14调节CDC42稳定性促进缺血后肢血管新生
Xian Ding,Yuxin Zhang,Yuting Zeng et al.
Xian Ding et al.
Critical limb ischemia (CLI) is a refractory peripheral artery disease characterized by tissue ischemia, presenting significant therapeutic challenges. Current surgical revascularization treatments are limited by indications, complications,...
RE: acute aortic dissection in a patient with hereditary hemorrhagic telangiectasia associated with juvenile polyposis due to SMAD4 mutation [0.03%]
带有多发性幼年性息肉病综合征基因突变的遗传性出血性毛细血管扩张症患者的急性主动脉夹层病例报告
Ehab Y Harahsheh,George Bcharah,Misha B Asif et al.
Ehab Y Harahsheh et al.
UHRF1 in endothelial cells is essential for angiogenesis and associated with the activation of pro-angiogenic signaling pathways and expression of endothelial genes [0.03%]
内皮细胞中的 Uhrf1 在血管生成中起关键作用，并与促血管生成信号通路的激活和内皮基因表达有关
Ying Liu,Jiake Mo,Zi Guo et al.
Ying Liu et al.
Epigenetics is increasingly recognized as a crucial factor in angiogenesis. Ubiquitin-like with PHD and RING Finger Domains 1 (UHRF1) is an important epigenetic regulatory protein involved in regulating cellular life processes, developing m...
Angiopoietin-2 binds to FGFR2, inhibits FGF-FGFR2 signaling, and delays cutaneous wound healing by inhibiting wound angiogenesis [0.03%]
血管生成素-2与FGFR2结合，通过抑制伤口血管生成来抑制FGF-FGFR2信号并延迟创面愈合
Minji Sim,Hidetaka Ohnuki,Stewart Durell et al.
Minji Sim et al.
Wound healing is an essential repair process, and impaired wound healing is a common and sometimes debilitating medical problem. Despite advances in wound healing approaches, optimal management strategies are lacking, partly due to an incom...
Mayumi F Miller,Leah J Greenspan,Derek E Gildea et al.
Mayumi F Miller et al.
Vascular endothelial cells in vivo are exquisitely regulated by their local environment, which is disrupted or absent when using methods such as FACS sorting of cells isolated from animals or in vitro cell culture. Here, we profile the gene...
Semaphorin 3A protects against thoracic aortic aneurysm dissection by suppressing aortic angiogenesis [0.03%]
血管生成抑制剂 Semaphorin 3A 可预防胸主动脉瘤及夹层形成
Li-Fei Wu,Jiao-Jiao Zhang,Xing Zhang et al.
Li-Fei Wu et al.
Thoracic aortic aneurysm (TAA) is life-threatening once developing to sudden dissection (TAAD) or rupture. The pathogenesis of TAA remains poorly understood and there is no effective pharmacologic therapy. Increased aortic angiogenesis has ...
Proteoglycans and glycosaminoglycans: critical regulators in angiogenesis, vasculogenesis, and vascularized tissue engineering [0.03%]
蛋白聚糖和糖胺聚糖：在血管生成、血管发生及血管化组织工程中的关键调节因子
Binbin Lin,Tianyu Sun,Yiqi Feng et al.
Binbin Lin et al.
Reconstruction of the microvascular network is essential for tissue regeneration and functional repair. However, inadequate vascularization remains an arduous challenge, hindering graft survival in wound healing and regenerative medicine. A...
Mechanistic insights into endometriosis: roles of Streptococcus agalactiae and L-carnitine in lesion development and angiogenesis [0.03%]
子宫内膜异位症的发病机制研究：肠球菌和L-肉毒碱在病灶发生及新生血管形成中的作用
Yuan Zhuang,Ting Lyu,Yang Chen et al.
Yuan Zhuang et al.
Retrograde menstruation is a widely recognized etiological factor for endometriosis (EMs); however, it is not the sole cause, as not all affected women develop EMs. Emerging evidence suggests a significant association between the vaginal mi...
Endothelial GTPBP3 directs developmental angiogenesis and neovascularization after limb ischemia via the mtROS/HRl/ATF4/mTORC1 axis [0.03%]
内皮GTPBP3通过线粒体ROS/HRl/ATF4/mTORC1轴调控发育血管生成及缺血后新生血管形成
Donglu Qin,Jiarui Hu,Yang Yang et al.
Donglu Qin et al.
GTP binding protein 3 (GTPBP3) is a highly conserved enzyme involved in tRNA modification, is essential for 5-taurinomethyluridine (τm5U) biosynthesis, and is linked to mitochondrial dysfunction within cells. However, the specific roles of...
Genetic deletion of microRNA-15a/16-1 in pericytes stimulates cerebral angiogenesis and promotes functional recovery after ischemic stroke [0.03%]
遗传敲除周细胞中微小核糖核酸-15a / 16-1可促进缺血性卒中后脑血管生成并促进功能恢复
Ping Sun,Yang Xu,Tianqing Xiong et al.
Ping Sun et al.
Stroke is a leading cause of mortality and disability globally. Despite advancements in acute stroke therapies, patient outcomes with ischemic stroke remain suboptimal. Understanding its molecular mechanisms is crucial for developing effect...