From endothelial epigenetic switching to a vascular-readiness compass for cancer immunotherapy [0.03%]
从内皮表观遗传转换到血管成熟度指南助力癌症免疫治疗
M Vijayasimha,M Srikanth,Keerthi Rao
M Vijayasimha
Xuejing Liu,Alonso Tapia,Dongqiang Yuan et al.
Xuejing Liu et al.
Endothelial cells (ECs) are crucial in cancer development and progression, partly by regulating tumor angiogenesis and immune modulation. As a key component of the RNA-induced silencing complex, Argonaute 1 (AGO1) regulates tumor biology, y...
Soluble CD146 reflects altered endothelial and metabolic homeostasis in peripheral artery disease [0.03%]
可溶性CD146反映了外周动脉疾病中内皮和代谢稳态的改变
Haizam Oubari,Julien Labreuche,Charlotte Reytier et al.
Haizam Oubari et al.
Background: Peripheral Arterial Disease (PAD) is a prevalent but underdiagnosed pathology. Soluble CD146 (sCD146) was described as a marker of endothelial dysfunction and vascular congestion. ...
Prevascularized grafts with spatially organized MSC spheroids to accelerate therapeutic angiogenesis in ischemic disease [0.03%]
基于空间构型的MSC球状体血管化移植片加速缺血疾病治疗性新生血管形成
Jeonghyun Son,Aruzhan Naren,Hanan Jamal Mohamed et al.
Jeonghyun Son et al.
Objective: Ischemic diseases, characterized by impaired blood flow and progressive tissue necrosis, remain a major challenge in regenerative medicine. Surgical revascularization remains the gold standard for restoring blo...
Characterizing pancreatic cancer-associated fibroblast heterogeneity in vascular microphysiological systems [0.03%]
基于血管类器官系统描述胰腺癌相关成纤维细胞异质性
Charles W Blackledge,Sarah Gullion,Ian McCabe et al.
Charles W Blackledge et al.
Pancreatic Ductal Adenocarcinoma (PDAC), one of the deadliest cancer types, is dominated by a tumor microenvironment (TME) that is desmoplastic, immunosuppressive, and generally unresponsive to conventional cancer treatments. Cancer-Associa...
An Rnf213-deficient hypoperfusion model reveals Moyamoya-relevant neurovascular remodeling [0.03%]
缺RNF213低灌注模型揭示 moyamoya 血管重塑机制
Yuanyuan Dai,Xiaoxin Wu,Shuai Li et al.
Yuanyuan Dai et al.
Moyamoya disease (MMD) is a chronic cerebrovascular disorder characterized by progressive stenosis of the terminal portions of the bilateral internal carotid arteries and their major branches, accompanied by the development of an abnormal v...
Congenital portosystemic shunt with extensive collateralization in an adult with recurrent episodes of hyperammonemic encephalopathy [0.03%]
一位出现反复高氨血症性脑病发作的成人患者的先天性门体分流和广泛的侧支循环病变
David Melville,Mayowa A Osundiji
David Melville
HDAC inhibition reprograms stem cell fate to suppress infantile hemangioma vasculogenesis [0.03%]
组蛋白去乙酰化酶抑制剂可通过重编程血管祖细胞命运来抑制婴幼儿血管瘤发生发展中的内皮生成和类器官形成
Qiming Chen,Hao Rong,Chao Liu et al.
Qiming Chen et al.
Infantile hemangioma (IH), the most common vascular tumor of infancy, relies on hemangioma stem cells (HemSCs) to drive pathological vasculogenesis during the proliferating phase. While beta-blockers are currently first-line treatment for I...
Transcriptomic characters of cochlear vascular cells with pericyte-driven angiogenetic activity [0.03%]
具血管生成活性的耳蜗血管周细胞的转录组特征分析
Pingting Wang,Yunpei Zhang,Zhiqiang Hou et al.
Pingting Wang et al.
The normal structure and function of inner-ear blood vessels, including the microvascular network of the stria vascularis (SV) within the blood-labyrinth barrier (BLB), are essential for auditory function. Despite this, the genetic and mole...