Deletion of the angiopoietin receptor Tie2 enhances proliferation and sprouting of cardiac endothelial cells [0.03%]
血管生成素受体Tie2的缺失可增强心脏内皮细胞的增殖和出芽现象
Andrey Anisimov,Madeleine H Lackman,Hellmut G Augustin et al.
Andrey Anisimov et al.
Background: Endothelial cells (ECs) of the heart proliferate and form new vessels in response to vascular endothelial growth factor (VEGF), but VEGF has not benefited the therapy of cardiac ischemia because of its side ef...
IL-6 trans-signaling: an overlooked driver of retinal neovascularization? [0.03%]
IL-6反式信号传导：被忽视的视网膜新生血管化驱动因素？
Malte Jung,Jan N Ness,Melanie E Schwämmle et al.
Malte Jung et al.
Background: Vascular endothelial growth factor (VEGF) is regarded as the essential promoter of vitreoretinal vascular diseases that threaten eyesight, such as proliferative diabetic retinopathy (PDR). Therefore, VEGF is t...
Secreted frizzled-related proteins in angiogenesis: molecular mechanisms and clinical implications [0.03%]
分泌型frizzled相关蛋白在血管生成中的分子机制及临床意义
Wei Wu,Yukun Zhang,Weihua Song et al.
Wei Wu et al.
Angiogenesis, the formation of new blood vessels from pre-existing vasculature, is essential for tissue homeostasis, development, and repair. Dysregulation of this tightly regulated process contributes to a wide range of diseases, including...
Sex-specific angiogenic responses in endothelial cells-role of the pluripotency factor OCT4 [0.03%]
性特异的内皮细胞血管生成反应及多能性因子OCT4的作用
Junchul Shin,Junyoung Hong,Iuliia Molokotina et al.
Junchul Shin et al.
The study investigates the sex-specific effects of the pluripotency factor OCT4 deficiency in endothelial cells (ECs) on angiogenesis. OCT4 is known for its role in embryonic stem cells, but we recently found that it plays a protective role...
Endothelial LRRC8A mitigates pressure overload-induced cardiac hypertrophy by promoting coronary angiogenesis [0.03%]
内皮细胞LRRC8A通过促进冠状动脉新生血管生成缓解压力超负荷诱导的心脏肥大
Lingjun Jie,Baolong Feng,Yufan Zhou et al.
Lingjun Jie et al.
Objective: Clinical evidence has indicated that pressure overload-induced cardiac hypertrophy is closely linked with adverse cardiac outcomes. Endothelial dysfunction is a key contributor to the progression of cardiac hyp...
Hydroxychloroquine does not affect endotheliopathy or coagulopathy biomarkers in COVID-19: longitudinal results from the DisCoVeRy randomized trial [0.03%]
羟基氯喹不会影响新冠肺炎的内皮细胞病变或凝血生物标志物：来自DisCoVeRy随机试验的纵向研究结果
Clément R Massonnaud,Maya Hites,Nathan Peiffer-Smadja et al.
Clément R Massonnaud et al.
Background: Hydroxychloroquine (HCQ), long used for its immunomodulatory and vasculoprotective properties in autoimmune diseases such as antiphospholipid syndrome, was among the first drugs evaluated for COVID-19. Given t...
Clinical Trial
Angiogenesis. 2025 Dec 7;29(1):8. DOI:10.1007/s10456-025-10023-7 2025
Integrative single cell RNA and spatial profiling identify mechanisms of neonatal brain hemorrhage pathophysiology and repair [0.03%]
整合单细胞RNA和空间测序解析新生儿脑出血病理生理及修复机制
Santiago A Forero,Zhihua Chen,Ali Pirani et al.
Santiago A Forero et al.
Precise control of cell-cell communication networks within brain neurovascular units (NVUs) promotes normal tissue physiology. Dysregulation of these networks can lead to pathologies including uncontrolled angiogenesis, endothelial barrier ...
Freya Droege,Alexandre Guilhem,Nicolas Ricard et al.
Freya Droege et al.
Hereditary Hemorrhagic Telangiectasia (HHT) is a rare autosomal dominant vascular disorder characterized by mucocutaneous telangiectasias and visceral arteriovenous malformations (AVMs), which arise due to direct connections between arterie...
Endothelial clock regulates retinal angiogenesis and ganglion cell function [0.03%]
内皮细胞生理钟调控视网膜血管生成及节细胞功能
Vijay K Jidigam,Madison B Kirby,Joshua Gallop et al.
Vijay K Jidigam et al.
Angiogenesis, the formation of new blood vessels from existing ones, is essential for physiological and pathological processes such as wound healing, organ development, and tumor growth. It is a tightly regulated process influenced by both ...
BMP9 knockout impairs pulmonary vessel muscularisation and confers aberrant tamoxifen sensitivity [0.03%]
BMP9敲除损害肺血管肌层化并导致他莫昔芬敏感性异常
Benjamin J Dunmore,Stephen Moore,Rowena J Jones et al.
Benjamin J Dunmore et al.
Deleterious mutations in the GDF2 gene, encoding BMP9, are causative of pulmonary arterial hypertension and hereditary haemorrhagic telangiectasia. Paradoxically, BMP9 germ-line knockout (Gdf2-/-; Bmp9 KO) and double Bmp9 KO/conditional Bmp...