Oscillatory contractile forces refine endothelial cell-cell interactions for continuous lumen formation governed by Heg1/Ccm1 [0.03%]
由Heg1/Ccm1调控的振荡收缩力优化内皮细胞相互作用形成连续管腔
Jianmin Yin,Ludovico Maggi,Cora Wiesner et al.
Jianmin Yin et al.
The formation and organization of complex blood vessel networks rely on various biophysical forces, yet the mechanisms governing endothelial cell-cell interactions under different mechanical inputs are not well understood. Using the dorsal ...
Sialyl Lewis X decorated integrin α3 on small extracellular vesicles promotes metastasis of bladder cancer via enhancing vascular permeability [0.03%]
唾液乳糖链蛋白修饰的整合素α3促进小细胞外囊泡介导的血管通透性增强及膀胱癌转移
Hui Feng,Liang Liang,Wenli Deng et al.
Hui Feng et al.
The permeability of blood vessels plays a crucial role in the spread of cancer cells, facilitating their metastasis at distant sites. Small extracellular vesicles (sEVs) are known to contribute to the metastasis of various cancers by crossi...
Senescent endothelial cells: a potential target for diabetic retinopathy [0.03%]
衰老内皮细胞：糖尿病视网膜病的潜在治疗靶点
Ying-Lu Liao,Yi-Fan Fang,Jia-Xing Sun et al.
Ying-Lu Liao et al.
Diabetic retinopathy (DR) is a diabetic complication that results in visual impairment and relevant retinal diseases. Current therapeutic strategies on DR primarily focus on antiangiogenic therapies, which particularly target vascular endot...
Soluble FLT-1 in angiogenesis: pathophysiological roles and therapeutic implications [0.03%]
可溶性FLT-1在血管生成中的作用及意义：病理生理作用和治疗意义
Layal Ei Wazan,Ariel Widhibrata,Guei-Sheung Liu
Layal Ei Wazan
Fine-tuning angiogenesis, the development of new blood vessels, is essential for maintaining a healthy circulatory and lymphatic system. The small glycoprotein vascular endothelial growth factors (VEGF) are the key mediators in this process...
The angiogenic role of the alpha 9-nicotinic acetylcholine receptor in triple-negative breast cancers [0.03%]
α9-烟碱型乙酰胆碱受体在三阴性乳腺癌中的血管生成作用
Sonjid Ochirbat,Tzu-Chun Kan,Chun-Chun Hsu et al.
Sonjid Ochirbat et al.
Nicotine acts as an angiogenic factor by stimulating endogenous cholinergic pathways. Several subtypes of nicotinic acetylcholine receptors (nAChRs) have been demonstrated to be closely correlated to the formation and progression of differe...
Maternal serum PlGF associates with 3D power doppler ultrasound markers of utero-placental vascular development in the first trimester: the rotterdam periconception cohort [0.03%]
早孕期母体血清PlGF与子宫胎盘血管发育的三维功率多普勒超声标记物相关：来自鹿特丹孕前队列的研究
Eline S de Vos,A H Jan Danser,Anton H J Koning et al.
Eline S de Vos et al.
Objective (s): Circulating angiogenic factors are used for prediction of placenta-related complications, but their associations with first-trimester placental development is unknown. This study investigates associations b...
Observational Study
Angiogenesis. 2024 Nov;27(4):797-808. DOI:10.1007/s10456-024-09939-3 2024
PDPN/CCL2/STAT3 feedback loop alter CAF heterogeneity to promote angiogenesis in colorectal cancer [0.03%]
PDPN/CCL2/STAT3反馈回路改变CAF异质性以促进结直肠癌血管生成
Die Yu,Hanzheng Xu,Jinzhe Zhou et al.
Die Yu et al.
Colorectal cancer (CRC) is one of the common clinical malignancies and the fourth leading cause of cancer-related death in the world. The tumor microenvironment (TME) plays a crucial role in promoting tumor angiogenesis, and cancer-associat...
Mitochondrial control of hypoxia-induced pathological retinal angiogenesis [0.03%]
线粒体控制低氧诱导的病理性视网膜血管增生
Hitomi Yagi,Myriam Boeck,Shen Nian et al.
Hitomi Yagi et al.
Objective: Pathological retinal neovascularization is vision-threatening. In mouse oxygen-induced retinopathy (OIR) we sought to define mitochondrial respiration changes longitudinally during hyperoxia-induced vessel loss...
Emerging insights into the pathogenesis and therapeutic strategies for vascular endothelial injury-associated diseases: focus on mitochondrial dysfunction [0.03%]
血管内皮损伤相关疾病发病机制及治疗策略的新见解——聚焦线粒体功能障碍
Boxian Pang,Guangtong Dong,Tieliang Pang et al.
Boxian Pang et al.
As a vital component of blood vessels, endothelial cells play a key role in maintaining overall physiological function by residing between circulating blood and semi-solid tissue. Various stress stimuli can induce endothelial injury, leadin...
A streamlined method to generate endothelial cells from human pluripotent stem cells via transient doxycycline-inducible ETV2 activation [0.03%]
通过短暂的多西环素诱导ETV2激活，从人多能干细胞高效生成内皮细胞的方法
Allen Chilun Luo,Jiuhai Wang,Kai Wang et al.
Allen Chilun Luo et al.
The development of reliable methods for producing functional endothelial cells (ECs) is crucial for progress in vascular biology and regenerative medicine. In this study, we present a streamlined and efficient methodology for the differenti...