Timed topical dexamethasone eye drops improve mitochondrial function to prevent severe retinopathy of prematurity [0.03%]
定时给予糖皮质激素滴眼液可改善早产儿视网膜病变的线粒体功能以预防增生性视网膜病变
Hitomi Yagi,Myriam Boeck,Mariya Petrishka-Lozenska et al.
Hitomi Yagi et al.
Pathological neovascularization in retinopathy of prematurity (ROP) can cause visual impairment in preterm infants. Current ROP treatments which are not preventative and only address late neovascular ROP, are costly and can lead to severe c...
The influences of ApoE isoforms on endothelial adherens junctions and actin cytoskeleton responding to mCRP [0.03%]
载脂蛋白E亚型影响mCRP诱导的血管内皮细胞黏着带和肌动蛋白细胞骨架重构的作用机制研究
Zhengrong Zhang,Weiwei Lin,Qini Gan et al.
Zhengrong Zhang et al.
Apolipoprotein E4 (ApoE4) plays an important role responding to monomeric C-reactive protein (mCRP) via binding to CD31 leading to cerebrovascular damage and Alzheimer's disease (AD). Using phosphor-proteomic profiling, we found altered cyt...
Oscillatory contractile forces refine endothelial cell-cell interactions for continuous lumen formation governed by Heg1/Ccm1 [0.03%]
由Heg1/Ccm1调控的振荡收缩力优化内皮细胞相互作用形成连续管腔
Jianmin Yin,Ludovico Maggi,Cora Wiesner et al.
Jianmin Yin et al.
The formation and organization of complex blood vessel networks rely on various biophysical forces, yet the mechanisms governing endothelial cell-cell interactions under different mechanical inputs are not well understood. Using the dorsal ...
Sialyl Lewis X decorated integrin α3 on small extracellular vesicles promotes metastasis of bladder cancer via enhancing vascular permeability [0.03%]
唾液乳糖链蛋白修饰的整合素α3促进小细胞外囊泡介导的血管通透性增强及膀胱癌转移
Hui Feng,Liang Liang,Wenli Deng et al.
Hui Feng et al.
The permeability of blood vessels plays a crucial role in the spread of cancer cells, facilitating their metastasis at distant sites. Small extracellular vesicles (sEVs) are known to contribute to the metastasis of various cancers by crossi...
Senescent endothelial cells: a potential target for diabetic retinopathy [0.03%]
衰老内皮细胞：糖尿病视网膜病的潜在治疗靶点
Ying-Lu Liao,Yi-Fan Fang,Jia-Xing Sun et al.
Ying-Lu Liao et al.
Diabetic retinopathy (DR) is a diabetic complication that results in visual impairment and relevant retinal diseases. Current therapeutic strategies on DR primarily focus on antiangiogenic therapies, which particularly target vascular endot...
Soluble FLT-1 in angiogenesis: pathophysiological roles and therapeutic implications [0.03%]
可溶性FLT-1在血管生成中的作用及意义：病理生理作用和治疗意义
Layal Ei Wazan,Ariel Widhibrata,Guei-Sheung Liu
Layal Ei Wazan
Fine-tuning angiogenesis, the development of new blood vessels, is essential for maintaining a healthy circulatory and lymphatic system. The small glycoprotein vascular endothelial growth factors (VEGF) are the key mediators in this process...
The angiogenic role of the alpha 9-nicotinic acetylcholine receptor in triple-negative breast cancers [0.03%]
α9-烟碱型乙酰胆碱受体在三阴性乳腺癌中的血管生成作用
Sonjid Ochirbat,Tzu-Chun Kan,Chun-Chun Hsu et al.
Sonjid Ochirbat et al.
Nicotine acts as an angiogenic factor by stimulating endogenous cholinergic pathways. Several subtypes of nicotinic acetylcholine receptors (nAChRs) have been demonstrated to be closely correlated to the formation and progression of differe...
Maternal serum PlGF associates with 3D power doppler ultrasound markers of utero-placental vascular development in the first trimester: the rotterdam periconception cohort [0.03%]
早孕期母体血清PlGF与子宫胎盘血管发育的三维功率多普勒超声标记物相关：来自鹿特丹孕前队列的研究
Eline S de Vos,A H Jan Danser,Anton H J Koning et al.
Eline S de Vos et al.
Objective (s): Circulating angiogenic factors are used for prediction of placenta-related complications, but their associations with first-trimester placental development is unknown. This study investigates associations b...
Observational Study
Angiogenesis. 2024 Nov;27(4):797-808. DOI:10.1007/s10456-024-09939-3 2024
PDPN/CCL2/STAT3 feedback loop alter CAF heterogeneity to promote angiogenesis in colorectal cancer [0.03%]
PDPN/CCL2/STAT3反馈回路改变CAF异质性以促进结直肠癌血管生成
Die Yu,Hanzheng Xu,Jinzhe Zhou et al.
Die Yu et al.
Colorectal cancer (CRC) is one of the common clinical malignancies and the fourth leading cause of cancer-related death in the world. The tumor microenvironment (TME) plays a crucial role in promoting tumor angiogenesis, and cancer-associat...
Mitochondrial control of hypoxia-induced pathological retinal angiogenesis [0.03%]
线粒体控制低氧诱导的病理性视网膜血管增生
Hitomi Yagi,Myriam Boeck,Shen Nian et al.
Hitomi Yagi et al.
Objective: Pathological retinal neovascularization is vision-threatening. In mouse oxygen-induced retinopathy (OIR) we sought to define mitochondrial respiration changes longitudinally during hyperoxia-induced vessel loss...