PINCH proteins orchestrate vascular mural cell homeostasis through integrated signaling and transcriptional networks [0.03%]
PINCH蛋白通过整合信号传导和转录网络调控血管周细胞稳态
Chunxiao Wang,Yao Jin,Yuanfeng Xin et al.
Chunxiao Wang et al.
Vascular mural cells (VMCs) are crucial for vascular stability, and their dysfunction underlies cardiovascular pathologies including atherosclerosis and aortic aneurysms. PINCH proteins are core focal adhesion components mediating integrin ...
Progressive endothelial coverage enhances hemocompatibility and prevents calcification in bioprosthetic valve tissue [0.03%]
逐步内皮化可提高生物心脏瓣膜组织的血液相容性并防止其钙化
Bastien Poitier,Ulysse Richez,Joseph Roux-de-Bezieux et al.
Bastien Poitier et al.
Background: Exploring the hemocompatibility of bioprosthetic heart valves (BHVs) has been challenging due to the scarcity of non-degenerated material. Obj...
ATP-citrate lyase is a critical regulator of physiological and pathological angiogenesis [0.03%]
丙二酸乳酸酶是生理和病理血管生成的关键调节因子
Chong Xu,Ying Lin,Zeyu Wang et al.
Chong Xu et al.
Sprouting angiogenesis requires endothelial cells (ECs) to transition into specialized tip and stalk cells, a process influenced by metabolic regulation. ATP-citrate lyase (ACLY), which generates acetyl-CoA from citrate, is markedly activat...
Francesco De Giorgio,Giuseppe Mannino,Veronica Bonalume et al.
Francesco De Giorgio et al.
Heme is an essential iron-containing porphyrin that plays a critical role in endothelial cell (EC) function, regulating processes such as cell signalling and energetic metabolism. Nevertheless, the role of de novo heme synthesis and porphyr...
Advanced technologies of artery-on-a-chip: a review of construction strategies and disease models [0.03%]
动脉芯片的先进制作技术及疾病模型研究综述
Shi-Qi Chang,Li Qiao,Oluwatosin David Abodunrin et al.
Shi-Qi Chang et al.
Cardiovascular disease (CVD) is the leading cause of death worldwide, with arteries being the most common site of CVDs. Diseases caused by abnormal arterial morphology and dysfunction (e.g., atherosclerosis, arterial thrombosis) often have ...
Vascular normalization by erianin unleashes CAR-T immunotherapy in glioblastoma [0.03%]
姜黄素类似物表没食子儿茶素-3-单甲醚通过正常化脑肿瘤血管促进CAR-T细胞免疫治疗
Shiling Zhou,Shuyi Qian,Bowen Sun et al.
Shiling Zhou et al.
Aberrant tumor vasculature is a major barrier limiting the efficacy of immunotherapy, including chimeric antigen receptor T-cell (CAR-T) therapy in solid tumors, by restricting T cell infiltration and impairing their functional activity. Gl...
Making sex-specific endothelial OCT4 biology implementation-ready: separating chromosomal and hormonal effects and standardizing translational endpoints [0.03%]
建立性别特异性内皮细胞OCT4生物学：分离染色体和激素效应及标准化转化终点
M Vijayasimha,M Srikanth,Rajeev Kumar Jha
M Vijayasimha
Calcineurin-NFAT-DSCR1.4 signaling as druggable axis in Gαq-R183Q-driven capillary malformations [0.03%]
Gαq-R183Q驱动的毛细血管畸形中可药物靶向轴Calcineurin-NFAT-DSCR1.4信号通路
Tong Xu,Vera Janssen,Nathalie R Reinhard et al.
Tong Xu et al.
Capillary malformations (CMs) are congenital vascular lesions caused by somatic mutations in the GNAQ gene, most frequently resulting in a p.R183Q substitution in the Gαq protein in endothelial cells. However, the downstream signaling path...
Alba Pau-Navalón,Tamara González-Costa,María Lancho Lavilla et al.
Alba Pau-Navalón et al.
Angiogenesis, the formation of new blood vessels from existing ones, is crucial for both development and disease. Its dysregulation is associated with diseases such as cancer, obesity, and blindness. Vascular endothelial growth factor A (VE...