Deciphering Stromal Changes between Metastatic and Non-metastatic Canine Mammary Carcinomas [0.03%]
解码转移性和非转移性犬乳腺癌间质的变化
Julia Ettlin,Alina Bauer,Lennart Opitz et al.
Julia Ettlin et al.
Cancer-associated stroma (CAS) is widely recognized to influence development and progression of epithelial tumours including breast cancer. Canine mammary tumours (CMTs) such as simple canine mammary carcinomas represent valuable models for...
PI3K inhibition circumvents resistance to SHP2 blockade in metastatic triple-negative breast cancer [0.03%]
PI3K抑制可绕过转移性三阴性乳腺癌对SHP2阻断的耐药性
Romain J Amante,Charly Jehanno,Duvini De Silva et al.
Romain J Amante et al.
The protein tyrosine phosphatase SHP2 activates oncogenic pathways downstream of most receptor tyrosine kinases (RTK) and has been implicated in various cancer types, including the highly aggressive subtype of triple-negative breast cancer ...
Molecular Characterization and Landscape of Breast cancer Models from a multi-omics Perspective [0.03%]
基于组学视角的乳腺癌模型分子特征及图谱研究
Mylena M O Ortiz,Eran R Andrechek
Mylena M O Ortiz
Breast cancer is well-known to be a highly heterogenous disease. This facet of cancer makes finding a research model that mirrors the disparate intrinsic features challenging. With advances in multi-omics technologies, establishing parallel...
Alysia L Vang,Tiago Bresolin,Waneska S Frizzarini et al.
Alysia L Vang et al.
Many studies on bovine mammary glands focus on one stage of development. Often missing in those studies are repeated measures of development from the same animals. As milk production is directly affected by amount of parenchymal tissue with...
ERBB Receptors and Their Ligands in the Developing Mammary Glands of Different Species: Fifteen Characters in Search of an Author [0.03%]
不同种类中发育乳腺中的ERBB受体及其配体：寻找作者的十五个角色
Alessia Morato,Paolo Accornero,Russell C Hovey
Alessia Morato
The ERBB tyrosine kinase receptors and their ligands belong to a complex family that has diverse biological effects and expression profiles in the developing mammary glands, where its members play an essential role in translating hormone si...
FGFR2 Controls Growth, Adhesion and Migration of Nontumorigenic Human Mammary Epithelial Cells by Regulation of Integrin β1 Degradation [0.03%]
FGFR2通过调控整合素β1降解来控制非致瘤性人类乳腺上皮细胞的生长、粘附和迁移能力
Kamil Mieczkowski,Marta Popeda,Dagmara Lesniak et al.
Kamil Mieczkowski et al.
The role of fibroblast growth factor receptor 2 (FGFR2), an important mediator of stromal paracrine and autocrine signals, in mammary gland morphogenesis and breast cancer has been extensively studied over the last years. However, the funct...
Culture Models to Investigate Mechanisms of Milk Production and Blood-Milk Barrier in Mammary Epithelial Cells: a Review and a Protocol [0.03%]
用于研究乳腺上皮细胞产乳机制及血乳屏障的培养模型：综述与方案
Ken Kobayashi
Ken Kobayashi
Mammary epithelial cells (MECs) are the only cell type that produces milk during lactation. MECs also form less-permeable tight junctions (TJs) to prevent the leakage of milk and blood components through the paracellular pathway (blood-milk...
The Serotonergic System and Bone Metabolism During Pregnancy and Lactation and the Implications of SSRI Use on the Maternal-Offspring Dyad [0.03%]
妊娠和哺乳期血清素系统与骨代谢以及选择性5-羟色胺再摄取抑制剂使用对母子对的影响
Hannah P Fricke,Laura L Hernandez
Hannah P Fricke
Lactation is a physiological adaptation of the class Mammalia and is a product of over 200 million years of evolution. During lactation, the mammary gland orchestrates bone metabolism via serotonin signaling in order to provide sufficient c...
Associations Between Dog Breed and Clinical Features of Mammary Epithelial Neoplasia in Bitches: an Epidemiological Study of Submissions to a Single Diagnostic Pathology Centre Between 2008-2021 [0.03%]
2008年至2021年单个诊断病理中心提交的母狗乳腺上皮肿瘤与犬品种和临床特征的流行病学研究
Grace Edmunds,Sam Beck,Kedar Umakant Kale et al.
Grace Edmunds et al.
Mammary cancer is one of the most common neoplasms of dogs, primarily bitches. While studies have been carried out identifying differing risk of mammary neoplasia in different dog breeds, few studies have reported associations between dog b...
Correction to: Rank ectopic expression in the presence of Neu and PyMT oncogenes alters mammary epithelial cell populations and their tumorigenic potential [0.03%]
纠正：Rank异位表达在Neu和PyMT致癌基因存在下改变乳腺上皮细胞群体及其致瘤潜能
Alex Cordero,Patricia G Santamaría,Eva González-Suárez
Alex Cordero