Characterizing Human Milk RNA Degradation Over Time to Optimize Storage of Human Milk for RNA Quality [0.03%]
人乳RNA质量优化的人乳RNA储存时间特征分析
Meghan R Crimmins,Brittany Reed,Larissa L da Cruz et al.
Meghan R Crimmins et al.
Human milk is rich in bioactive components beyond nutrition, including RNAs-especially miRNAs. It is the most RNA-rich biofluid. While storage effects on other milk components are well studied, RNA preservation has been minimally explored, ...
Increased Toll-Like Receptor-4 Signalling in Breast Tissue of High Fibroglandular Density [0.03%]
高纤维导管密度乳腺组织中 toll 样受体 4(tlr-4) 信号转导增强
Hanieh Heydarlou,Leigh J Hodson,Pallave Dasari et al.
Hanieh Heydarlou et al.
Imaging and Diagnostic Tools for Cetacean Mammary Gland Assessment: Challenges and Future Directions for Marine Mammal Pathology, Medicine and Research [0.03%]
鲸类乳腺评估的影像学和诊断工具：海洋哺乳动物病理学、医学和研究面临的挑战及未来方向
María José Robles-Malagamba,Tommaso Gerussi,Guillermo J Sánchez-Contreras et al.
María José Robles-Malagamba et al.
Reproduction studies are important for the conservation of cetaceans (whales, dolphins, and porpoises) because they provide essential information for assessing populations and species dynamics, particularly in relation to the management of ...
Breast Cancer Progression by the FGF/FGFR Axis: A Metabolic Perspective [0.03%]
FGF/FGFR轴在乳腺癌代谢中的作用及其促进乳腺癌进展的作用机制研究
Jennifer E Tuokkola,Kathryn L Schwertfeger
Jennifer E Tuokkola
Fibroblast growth factor receptors (FGFRs) are critical mediators of cellular signaling involved in development, tissue repair, and metabolic homeostasis. Dysregulated FGFR signaling is also a common feature in multiple cancer types, includ...
BRCA1: An Unrecognized Modulator of Lineage Plasticity in Basal-like Breast Cancer [0.03%]
BRCA1：基底样乳腺癌中一种未被认识的谱系可塑性调节因子
Rahul Sanawar,Satheesh Kumar Sengodan
Rahul Sanawar
Among breast cancer subtypes, basal-like breast cancer (BLBC) is a highly aggressive form characterized by a lack of estrogen receptor (ER), progesterone receptor (PR), and the human epidermal growth factor receptor (HER2) expression and is...
Little women: the relevance and reliance on mouse models for mammary gland research and next steps for translation [0.03%]
小鼠标：乳腺研究中鼠类模型的相关性和依赖性及今后的转化方向
Laura B Bjerre,Silke B Chalmers,Felicity M Davis
Laura B Bjerre
The neglect of research into women's health and female biology has had major impacts for the fields of mammary biology and cancer. A quarter of the way through the twenty-first century, we still lack basic knowledge regarding the formation ...
Natural and induced epithelial-mesenchymal transition results in epigenetic silencing of HER2 overexpression [0.03%]
上皮间质转化诱导HER2高表达的表观遗传学沉默化
Kiandra N Hawkins,Jordan Dillard,Yin Ye et al.
Kiandra N Hawkins et al.
Epithelial-mesenchymal transition (EMT) is a well-known phenomenon that has been implicated in diverse biological processes ranging from embryonal development to cancer invasion and metastasis. In epithelial-derived cancers which both invad...
Does microtubule motor-mediated centrosomal dyshomeostasis confer chemoresistance in breast cancer? [0.03%]
乳腺癌中微管马达介导的中心体稳态失调是否赋予化学抗性？
J Priyanga,Gunjan Guha,Dipita Bhakta-Guha
J Priyanga
Chemoresistance is a major challenge in effective chemotherapy for breast cancers. Unfortunately, the precise molecular mechanisms that confer resistance remain elusive so far. A remarkable feature in a multitude of breast cancers is the pr...
MaGNet: A Network-Based Method for Quantitative Analysis of the Mammary Ductal Tree in Developing Female Mice [0.03%]
基于网络的定量分析发育小鼠乳腺导管树的新方法
Steven M Lewis,Lucia Tellez-Perez,Samantha Henry et al.
Steven M Lewis et al.
The mammary gland is a uniquely dynamic organ with a branching architecture that develops entirely after birth in response to hormonal cues. A common approach in mammary gland biology is the evaluation of branching morphogenesis to characte...
Live-cell imaging of mammary organoids using light sheet microscopy [0.03%]
平面照明显微镜活细胞成像观测类器官模型乳房组织中的上皮间质转化现象
Matea Brezak,Azqa Ajmal Khan,Martin Jechlinger et al.
Matea Brezak et al.
The mammary gland is a dynamic organ whose parenchyma undergoes major development during puberty and extensive remodeling with each estrous cycle. These processes can be modelled and investigated in vitro via 3D cell culture techniques that...