Distinct Requirements for Adaptor Proteins NCK1 and NCK2 in Mammary Gland Development [0.03%]
NCK1和NCK2在乳腺发育中具有不同作用
Adam P Golding,Benjamin Ferrier,Laura A New et al.
Adam P Golding et al.
The adaptor proteins NCK1 and NCK2 are well-established signalling nodes that regulate diverse biological processes including cell proliferation and actin dynamics in many tissue types. Here we have investigated the distribution and functio...
Gestational Breast Cancer - a Review of Outcomes, Pathophysiology, and Model Systems [0.03%]
妊娠期乳腺癌——结局、病理生理和模型系统的综述
Mackenzie K Callaway,Camila O Dos Santos
Mackenzie K Callaway
The onset of pregnancy marks the start of offspring development, and represents the key physiological event that induces re-organization and specialization of breast tissue. Such drastic tissue remodeling has also been linked to epithelial ...
Studying Mammary Physiology and Pathology in Domestic Species Benefits Both Humans and Animals [0.03%]
家畜乳腺生理和病理学的研究造福人类和动物健康
Katherine Hughes
Katherine Hughes
Imagine beyond: recent breakthroughs and next challenges in mammary gland biology and breast cancer research [0.03%]
展望超越：乳腺生物学和乳腺癌研究中的近期突破及未来挑战
Renée van Amerongen,Mohamed Bentires-Alj,Antonius L van Boxtel et al.
Renée van Amerongen et al.
On 8 December 2022 the organizing committee of the European Network for Breast Development and Cancer labs (ENBDC) held its fifth annual Think Tank meeting in Amsterdam, the Netherlands. Here, we embraced the opportunity to look back to ide...
SFRP1 Expression is Inversely Associated With Metastasis Formation in Canine Mammary Tumours [0.03%]
SFRP1的表达与犬乳腺肿瘤转移形成的负相关关系
Judith Seitz,Alan Bilsland,Chloé Puget et al.
Judith Seitz et al.
Background: Canine mammary tumours (CMTs) are the most frequent tumours in intact female dogs and show strong similarities with human breast cancer. In contrast to the human disease there are no standardised diagnostic or...
Deciphering Stromal Changes between Metastatic and Non-metastatic Canine Mammary Carcinomas [0.03%]
解码转移性和非转移性犬乳腺癌间质的变化
Julia Ettlin,Alina Bauer,Lennart Opitz et al.
Julia Ettlin et al.
Cancer-associated stroma (CAS) is widely recognized to influence development and progression of epithelial tumours including breast cancer. Canine mammary tumours (CMTs) such as simple canine mammary carcinomas represent valuable models for...
PI3K inhibition circumvents resistance to SHP2 blockade in metastatic triple-negative breast cancer [0.03%]
PI3K抑制可绕过转移性三阴性乳腺癌对SHP2阻断的耐药性
Romain J Amante,Charly Jehanno,Duvini De Silva et al.
Romain J Amante et al.
The protein tyrosine phosphatase SHP2 activates oncogenic pathways downstream of most receptor tyrosine kinases (RTK) and has been implicated in various cancer types, including the highly aggressive subtype of triple-negative breast cancer ...
Molecular Characterization and Landscape of Breast cancer Models from a multi-omics Perspective [0.03%]
基于组学视角的乳腺癌模型分子特征及图谱研究
Mylena M O Ortiz,Eran R Andrechek
Mylena M O Ortiz
Breast cancer is well-known to be a highly heterogenous disease. This facet of cancer makes finding a research model that mirrors the disparate intrinsic features challenging. With advances in multi-omics technologies, establishing parallel...
Alysia L Vang,Tiago Bresolin,Waneska S Frizzarini et al.
Alysia L Vang et al.
Many studies on bovine mammary glands focus on one stage of development. Often missing in those studies are repeated measures of development from the same animals. As milk production is directly affected by amount of parenchymal tissue with...
ERBB Receptors and Their Ligands in the Developing Mammary Glands of Different Species: Fifteen Characters in Search of an Author [0.03%]
不同种类中发育乳腺中的ERBB受体及其配体：寻找作者的十五个角色
Alessia Morato,Paolo Accornero,Russell C Hovey
Alessia Morato
The ERBB tyrosine kinase receptors and their ligands belong to a complex family that has diverse biological effects and expression profiles in the developing mammary glands, where its members play an essential role in translating hormone si...