15th Annual ENBDC Meeting: How do Cellular Potency, Microenvironment and Natural Rhythms Influence Mammary Gland Biology and Breast Cancer? [0.03%]
第十五届ENBDC会议：细胞活力，微环境和自然节律如何影响乳腺生物学和乳腺癌？
Maria Rafaeva,Beata Kaczyńska,Jaime Redondo-Pedraza et al.
Maria Rafaeva et al.
Following previous editions, the fifteenth annual workshop of the European Network for Breast Development and Cancer (ENBDC) on Methods in Mammary Gland Biology and Breast Cancer was held from the 2nd to the 4th of May in Weggis, Switzerlan...
Gestational breast cancer: distinctive molecular and clinico-epidemiological features [0.03%]
妊娠期乳腺癌：独特的分子和临床流行病学特征
J R de la Haba-Rodríguez,P Mínguez,F Rojo et al.
J R de la Haba-Rodríguez et al.
Gestational breast cancer (GBC), defined as breast cancer (BC) diagnosed during pregnancy or the first-year post-partum, accounts for 6-15% of BC cases in women aged 20-44 years. GBC has worse prognosis than non-GBC, but reasons behind are ...
Observational Study
Journal of mammary gland biology and neoplasia. 2024 Nov 8;29(1):18. DOI:10.1007/s10911-024-09571-3 2024
Maia N Machiela,Russell C Hovey
Maia N Machiela
Thymidine analogs such as ethynyl deoxyuridine (EdU) or bromodeoxyuridine (BrdU) can be used to label mitosis of mammary epithelial cells (MEC) and to quantify their proliferation. However, labeling cells in larger animals requires consider...
Ramiah Vickers,Weston Porter
Ramiah Vickers
Postpartum breast cancer (PPBC) is a unique subset of breast cancer, accounting for nearly half of the women diagnosed during their postpartum years. Mammary gland involution is widely regarded as being a key orchestrator in the initiation ...
Perimenopausal and Menopausal Mammary Glands In A 4-Vinylcyclohexene Diepoxide Mouse Model [0.03%]
4-乙烯基环己烯二氧模型小鼠围绝经期及绝经期乳腺的形态学变化
Kohei Saeki,Desiree Ha,Gregory Chang et al.
Kohei Saeki et al.
As both perimenopausal and menopausal periods are recognized critical windows of susceptibility for breast carcinogenesis, development of a physiologically relevant model has been warranted. The traditional ovariectomy model causes instant ...
State of the Art Modelling of the Breast Cancer Metastatic Microenvironment: Where Are We? [0.03%]
乳腺癌转移微环境的现状及未来发展方向是什么？
Mia Nuckhir,David Withey,Sara Cabral et al.
Mia Nuckhir et al.
Metastatic spread of tumour cells to tissues and organs around the body is the most frequent cause of death from breast cancer. This has been modelled mainly using mouse models such as syngeneic mammary cancer or human in mouse xenograft mo...
Transcriptomic Analysis of Pubertal and Adult Virgin Mouse Mammary Epithelial and Stromal Cell Populations [0.03%]
青春期和成年小鼠处女乳腺上皮细胞和基质细胞的转录组分析
Nika Heijmans,Katrin E Wiese,Jos Jonkers et al.
Nika Heijmans et al.
Conflicting data exist as to how mammary epithelial cell proliferation changes during the reproductive cycle. To study the effect of endogenous hormone fluctuations on gene expression in the mouse mammary gland, we performed bulk RNAseq ana...
Raquel Nicotra,Catrin Lutz,Hendrik A Messal et al.
Raquel Nicotra et al.
Hormone receptor-positive (HR+) breast cancer (BC) is the most common type of breast cancer among women worldwide, accounting for 70-80% of all invasive cases. Patients with HR+ BC are commonly treated with endocrine therapy, but intrinsic ...
Methods for investigating STAT3 regulation of lysosomal function in mammary epithelial cells [0.03%]
探究STAT3调节乳腺上皮细胞溶酶体功能的方法
Bethan Lloyd-Lewis,Michael E D&#x;Angelo,Neve B Prowting et al.
Bethan Lloyd-Lewis et al.
The transcription factor STAT3 is activated by multiple cytokines and other extrinsic factors. It plays a key role in immune and inflammatory responses and, when dysregulated, in tumourigenesis. STAT3 is also an indispensable mediator of th...
In the Murine and Bovine Maternal Mammary Gland Signal Transducer and Activator of Transcription 3 is Activated in Clusters of Epithelial Cells around the Day of Birth [0.03%]
在小鼠和牛的乳腺中，信号转导及转录激活因子-3在出生前后乳管上皮细胞中以簇的形式被活化表达
Laura J A Hardwick,Benjamin P Davies,Sara Pensa et al.
Laura J A Hardwick et al.
Signal transducers and activators of transcription (STAT) proteins regulate mammary development. Here we investigate the expression of phosphorylated STAT3 (pSTAT3) in the mouse and cow around the day of birth. We present localised colocati...