State of the Art Modelling of the Breast Cancer Metastatic Microenvironment: Where Are We? [0.03%]
乳腺癌转移微环境的现状及未来发展方向是什么？
Mia Nuckhir,David Withey,Sara Cabral et al.
Mia Nuckhir et al.
Metastatic spread of tumour cells to tissues and organs around the body is the most frequent cause of death from breast cancer. This has been modelled mainly using mouse models such as syngeneic mammary cancer or human in mouse xenograft mo...
Transcriptomic Analysis of Pubertal and Adult Virgin Mouse Mammary Epithelial and Stromal Cell Populations [0.03%]
青春期和成年小鼠处女乳腺上皮细胞和基质细胞的转录组分析
Nika Heijmans,Katrin E Wiese,Jos Jonkers et al.
Nika Heijmans et al.
Conflicting data exist as to how mammary epithelial cell proliferation changes during the reproductive cycle. To study the effect of endogenous hormone fluctuations on gene expression in the mouse mammary gland, we performed bulk RNAseq ana...
Raquel Nicotra,Catrin Lutz,Hendrik A Messal et al.
Raquel Nicotra et al.
Hormone receptor-positive (HR+) breast cancer (BC) is the most common type of breast cancer among women worldwide, accounting for 70-80% of all invasive cases. Patients with HR+ BC are commonly treated with endocrine therapy, but intrinsic ...
Methods for investigating STAT3 regulation of lysosomal function in mammary epithelial cells [0.03%]
探究STAT3调节乳腺上皮细胞溶酶体功能的方法
Bethan Lloyd-Lewis,Michael E D&#x;Angelo,Neve B Prowting et al.
Bethan Lloyd-Lewis et al.
The transcription factor STAT3 is activated by multiple cytokines and other extrinsic factors. It plays a key role in immune and inflammatory responses and, when dysregulated, in tumourigenesis. STAT3 is also an indispensable mediator of th...
In the Murine and Bovine Maternal Mammary Gland Signal Transducer and Activator of Transcription 3 is Activated in Clusters of Epithelial Cells around the Day of Birth [0.03%]
在小鼠和牛的乳腺中，信号转导及转录激活因子-3在出生前后乳管上皮细胞中以簇的形式被活化表达
Laura J A Hardwick,Benjamin P Davies,Sara Pensa et al.
Laura J A Hardwick et al.
Signal transducers and activators of transcription (STAT) proteins regulate mammary development. Here we investigate the expression of phosphorylated STAT3 (pSTAT3) in the mouse and cow around the day of birth. We present localised colocati...
Anthony J Wilby,Sara Cabral,Nastaran Zoghi et al.
Anthony J Wilby et al.
Improved screening and treatment have decreased breast cancer mortality, although incidence continues to rise. Women at increased risk of breast cancer can be offered risk reducing treatments, such as tamoxifen, but this has not been shown ...
Kirsty Luo-Yng Tay,George Cowan,Subarnarekha Chatterji et al.
Kirsty Luo-Yng Tay et al.
How cancer patterns in humans compare to those of other species remains largely unknown and there is an even bigger knowledge gap for rare cancers like male breast cancer. One Health is a convergence of human and animal healthcare that enco...
Gat Rauner
Gat Rauner
This article offers a comprehensive perspective on the transformative role of organoid technology on mammary gland biology research across a diverse array of mammalian species.The mammary gland's unique development and regenerative capabili...
Traci R Lyons,Esta Sterneck
Traci R Lyons
Spatial Engineering of Mammary Epithelial Cell Cultures with 3D Bioprinting Reveals Growth Control by Branch Point Proximity [0.03%]
通过3D生物打印构建的乳腺上皮细胞培养的空间工程揭示了分支点 proximity 的生长控制
Leena M Koskinen,Lari Nieminen,Antti Arjonen et al.
Leena M Koskinen et al.
The three-dimensional (3D) structure of the ductal epithelium and the surrounding extracellular matrix (ECM) are integral aspects of the breast tissue, and they have important roles during mammary gland development, function and malignancy....