Does microtubule motor-mediated centrosomal dyshomeostasis confer chemoresistance in breast cancer? [0.03%]
乳腺癌中微管马达介导的中心体稳态失调是否赋予化学抗性？
J Priyanga,Gunjan Guha,Dipita Bhakta-Guha
J Priyanga
Chemoresistance is a major challenge in effective chemotherapy for breast cancers. Unfortunately, the precise molecular mechanisms that confer resistance remain elusive so far. A remarkable feature in a multitude of breast cancers is the pr...
MaGNet: A Network-Based Method for Quantitative Analysis of the Mammary Ductal Tree in Developing Female Mice [0.03%]
基于网络的定量分析发育小鼠乳腺导管树的新方法
Steven M Lewis,Lucia Tellez-Perez,Samantha Henry et al.
Steven M Lewis et al.
The mammary gland is a uniquely dynamic organ with a branching architecture that develops entirely after birth in response to hormonal cues. A common approach in mammary gland biology is the evaluation of branching morphogenesis to characte...
Live-cell imaging of mammary organoids using light sheet microscopy [0.03%]
平面照明显微镜活细胞成像观测类器官模型乳房组织中的上皮间质转化现象
Matea Brezak,Azqa Ajmal Khan,Martin Jechlinger et al.
Matea Brezak et al.
The mammary gland is a dynamic organ whose parenchyma undergoes major development during puberty and extensive remodeling with each estrous cycle. These processes can be modelled and investigated in vitro via 3D cell culture techniques that...
Reactivation of Multipotency in the Mammary Gland - a Ripple in the Pond and a Turn of the Tide [0.03%]
乳腺干细胞的多能性激活——一道涟漪与一股潮流
C Hager,C Jehanno,M Bentires-Alj
C Hager
Multipotency refers to the ability of a cell to differentiate into multiple, yet limited as opposed to pluripotency, number of cell types within a specific lineage or tissue. Studies using transgenic mouse models of the mammary gland have r...
Intraductal Injection of Adenoviruses to Perform Lineage Tracing in the Mammary Gland [0.03%]
乳腺导管内注射腺病毒进行谱系追踪
Xueqing Chen,Sen Han,Dongyi Zhao et al.
Xueqing Chen et al.
Lineage tracing is a fundamental tool in developmental biology and cancer research, providing critical insights into cell fate decisions, tissue homeostasis and tumor initiation. The mammary gland is a highly dynamic organ with a complex ce...
Carlos Ronchi,Giovanna Ambrosini,Flavia Hughes et al.
Carlos Ronchi et al.
Developmental Regulation of circRNAs in Normal and Diseased Mammary Gland: A Focus on circRNA-miRNA Networks [0.03%]
正常和病变乳腺中circRNAs的发育调控：重点关注circRNA-miRNA网络
Sarah Marei,Nour Maatouk,Mounir AbouHaidar et al.
Sarah Marei et al.
Circular RNAs (circRNAs) have emerged as critical regulators in various biological processes including diseases. In the mammary gland (MG), which undergoes most of its development postnatally, circRNAs play pivotal roles in both physiologic...
Disease-Associated Mutations of the STAT5B SH2 Domain Regulate Cytokine-Driven Enhancer Function and Mammary Development [0.03%]
与疾病相关的STAT5B SH2结构域突变可调节细胞因子驱动的增强子功能和乳腺发育
Hye Kyung Lee,Jakub Jankowski,Chengyu Liu et al.
Hye Kyung Lee et al.
Mammary gland development during pregnancy is controlled by lactogenic hormones via the JAK2-STAT5 pathway. Gene deletion studies in mice have revealed the crucial roles of both STAT5A and STAT5B in establishing the genetic programs necessa...
Association of ESR1, HER1, and HER2 Polymorphisms with Breast Cancer Risk in the KP Population, A Case-Control Study [0.03%]
ESR1、HER1和HER2基因多态性与KP人群乳腺癌易感性的关联病例对照研究
Najeeb Ullah Khan,Hamza Khan,Abdullah R Alanzi et al.
Najeeb Ullah Khan et al.
Breast cancer is a complex disease characterized by the uncontrolled growth of breast cells. Genetic variants in ESR1, HER1, and HER2 have been associated with breast cancer risk across different populations, with varying results. This stud...
Buenos Aires Breast Cancer Symposium (BA-BCS 2024) A Second Successful "Trial" for Bringing Together both World Hemispheres To Debate the Future of Translational Breast Cancer Research [0.03%]
布宜诺斯艾利斯乳腺癌研讨会（BA-BCS 2024）：将全球两大半球聚集在一起，讨论乳腺癌转化研究未来的第二次成功“尝试”
Claudia Lanari,Virginia Novaro,Mario Rossi et al.
Claudia Lanari et al.
The second edition of the Buenos Aires Breast Cancer Symposium (BA-BCS), the first held in person, took place from September 3rd to 6th in Buenos Aires, Argentina. This report provides an overview of the talks delivered as individual lectur...