Patient-Derived Procoagulant Breast Fibroblasts Expressing Tissue Factor Promote Breast Cancer Cell Migration [0.03%]
表达组织因子的患者来源促凝乳腺纤维母细胞促进癌细胞转移
Hadiyat A Ogunlayi,John Castle,Emma L Blower et al.
Hadiyat A Ogunlayi et al.
Insights from Genomic Sequencing of Preclinical Breast Cancer Models Establish Human Parallels to Increase Therapeutic Applicability [0.03%]
对乳腺癌临床前模型的基因组测序分析建立人类相关性以增加治疗适用性的启示
Anthony J Schulte,Eran R Andrechek
Anthony J Schulte
The study of breast cancer is complicated by the heterogeneity inherent within the disease. Numerous models have been developed to study the initiation, progression, and treatment of breast cancer. These include carcinogen induced mouse mod...
Synergistic Anticancer Effects of Apatinib and PD-L1 Inhibition in Breast Cancer [0.03%]
阿帕替尼联合PD-L1抑制在乳腺癌中的协同抗肿瘤作用
Danyang Han,Juanjuan Xu,Cairu Guo
Danyang Han
Studies in breast cancer have demonstrated that apatinib exhibits both antiangiogenic and antitumor effects, while PD-L1 inhibitors have similarly shown meaningful clinical benefit. Building upon these observations, this study evaluated the...
Characterizing Human Milk RNA Degradation Over Time to Optimize Storage of Human Milk for RNA Quality [0.03%]
人乳RNA质量优化的人乳RNA储存时间特征分析
Meghan R Crimmins,Brittany Reed,Larissa L da Cruz et al.
Meghan R Crimmins et al.
Human milk is rich in bioactive components beyond nutrition, including RNAs-especially miRNAs. It is the most RNA-rich biofluid. While storage effects on other milk components are well studied, RNA preservation has been minimally explored, ...
Increased Toll-Like Receptor-4 Signalling in Breast Tissue of High Fibroglandular Density [0.03%]
高纤维导管密度乳腺组织中 toll 样受体 4(tlr-4) 信号转导增强
Hanieh Heydarlou,Leigh J Hodson,Pallave Dasari et al.
Hanieh Heydarlou et al.
Imaging and Diagnostic Tools for Cetacean Mammary Gland Assessment: Challenges and Future Directions for Marine Mammal Pathology, Medicine and Research [0.03%]
鲸类乳腺评估的影像学和诊断工具：海洋哺乳动物病理学、医学和研究面临的挑战及未来方向
María José Robles-Malagamba,Tommaso Gerussi,Guillermo J Sánchez-Contreras et al.
María José Robles-Malagamba et al.
Reproduction studies are important for the conservation of cetaceans (whales, dolphins, and porpoises) because they provide essential information for assessing populations and species dynamics, particularly in relation to the management of ...
Breast Cancer Progression by the FGF/FGFR Axis: A Metabolic Perspective [0.03%]
FGF/FGFR轴在乳腺癌代谢中的作用及其促进乳腺癌进展的作用机制研究
Jennifer E Tuokkola,Kathryn L Schwertfeger
Jennifer E Tuokkola
Fibroblast growth factor receptors (FGFRs) are critical mediators of cellular signaling involved in development, tissue repair, and metabolic homeostasis. Dysregulated FGFR signaling is also a common feature in multiple cancer types, includ...
BRCA1: An Unrecognized Modulator of Lineage Plasticity in Basal-like Breast Cancer [0.03%]
BRCA1：基底样乳腺癌中一种未被认识的谱系可塑性调节因子
Rahul Sanawar,Satheesh Kumar Sengodan
Rahul Sanawar
Among breast cancer subtypes, basal-like breast cancer (BLBC) is a highly aggressive form characterized by a lack of estrogen receptor (ER), progesterone receptor (PR), and the human epidermal growth factor receptor (HER2) expression and is...
Little women: the relevance and reliance on mouse models for mammary gland research and next steps for translation [0.03%]
小鼠标：乳腺研究中鼠类模型的相关性和依赖性及今后的转化方向
Laura B Bjerre,Silke B Chalmers,Felicity M Davis
Laura B Bjerre
The neglect of research into women's health and female biology has had major impacts for the fields of mammary biology and cancer. A quarter of the way through the twenty-first century, we still lack basic knowledge regarding the formation ...
Natural and induced epithelial-mesenchymal transition results in epigenetic silencing of HER2 overexpression [0.03%]
上皮间质转化诱导HER2高表达的表观遗传学沉默化
Kiandra N Hawkins,Jordan Dillard,Yin Ye et al.
Kiandra N Hawkins et al.
Epithelial-mesenchymal transition (EMT) is a well-known phenomenon that has been implicated in diverse biological processes ranging from embryonal development to cancer invasion and metastasis. In epithelial-derived cancers which both invad...